General Information of the Protein
Protein ID
PT03558
Protein Name
P2Y purinoceptor 11
Gene Name
P2RY11
Sequence
MAANVSGAKSCPANFLAAADDKLSGFQGDFLWPILVVEFLVAVASNGLALYRFSIRKQRPWHPAVVFSVQLAVSDLLCALTLPPLAAYLYPPKHWRYGEAACRLERFLFTCNLLGSVIFITCISLNRYLGIVHPFFARSHLRPKHAWAVSAAGWVLAALLAMPTLSFSHLKRPQQGAGNCSVARPEACIKCLGTADHGLAAYRAYSLVLAGLGCGLPLLLTLAAYGALGRAVLRSPGMTVAEKLRVAALVASGVALYASSYVPYHIMRVLNVDARRRWSTRCPSFADIAQATAALELGPYVGYQVMRGLMPLAFCVHPLLYMAAVPSLGCCCRHCPGYRDSWNPEDAKSTGQALPLNATAAPKPSEPQSRELSQ
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Nucleotide-like receptor (family A GPCR)
>
Purine receptor
Function
Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.
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Uniprot ID
Primary ID:
Q96G91

Secondarily ID:
B2R8X9
O43190
Q9BYU4
Q9H170
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Ensembl ID
ENSG00000244165
HGNC ID
HGNC:8540
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000094 , 1321N1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0408366
 Compound Info 
ADENOSINE-5'-DIPHOSPHATE MONOTHIOPHOSPHATE
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C10H16N5O12P3S
  1
1
EC50 = 63.1 nM
 Bioactivity Info 
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CP0381284
 Compound Info 
CHEMBL2386496
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C11H16BCl3N5O11P3
  1
1
EC50 = 130 nM
 Bioactivity Info 
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CP0881793
 Compound Info 
8-carboxy-iso-iantheran A
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C33H16Br4Na2O14S2
  1
1
EC50 = 478.63 nM
 Bioactivity Info 
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CP0443921
 Compound Info 
[(2R,3S,4R,5R)-5-(6-amino-2-methylsulfanylpurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydroxyphosphinothioyl hydrogen phosphate
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C11H17N5O9P2S2
  1
1
EC50 = 900 nM
 Bioactivity Info 
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CP0085293
 Compound Info 
CHEMBL2386492
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C10H15BClN5O9P2
  1
1
EC50 = 1000 nM
 Bioactivity Info 
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CP0445231
 Compound Info 
[(2R,3S,4R,5R)-5-(6-amino-2-chloropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydroxyphosphinothioyl hydrogen phosphate
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C10H14ClN5O9P2S
  1
1
EC50 = 1000 nM
 Bioactivity Info 
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CP0854464
 Compound Info 
iso-iantheran A
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C32H16Br4Na2O12S2
  1
1
EC50 = 1288.25 nM
 Bioactivity Info 
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CP0529626
 Compound Info 
CHEMBL2386495
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C11H16BCl3N5O11P3
  1
1
EC50 = 1400 nM
 Bioactivity Info 
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CP0423034
 Compound Info 
[(2R,3R,4S,5R)-2-(6-amino-2-methylsulfanylpurin-9-yl)-4-hydroxy-5-[[hydroxy(phosphonooxy)phosphoryl]oxymethyl]oxolan-3-yl] benzoate
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C18H21N5O11P2S
  1
1
EC50 = 1500 nM
 Bioactivity Info 
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CP0043494
 Compound Info 
ADP
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C10H15N5O10P2
  1
1
EC50 = 1700 nM
 Bioactivity Info 
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CP0674107
 Compound Info 
(Sp)-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-phosphonatooxy-phosphoryl]boranuide
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C10H15BN5Na3O9P2
  1
1
EC50 = 2900 nM
 Bioactivity Info 
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CP0029805
 Compound Info 
({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid
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C10H16N5O13P3
  2
1
EC50 = 3300 nM
 Bioactivity Info 
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2
EC50 = 6700 nM
 Bioactivity Info 
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CP0733792
 Compound Info 
(Rp)-[[(2R,3S,4R,5R)-5-(6-amino-2-chloro-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-phosphonatooxy-phosphoryl]boranuide
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C10H15BClN5O9P2
  1
1
EC50 = 3680 nM
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CP0847500
 Compound Info 
pentasodium {[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}methyl)phosphinato]oxy}(boranuidyl)phosphoryl ({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}methyl)phosphonate
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C22H31BN10Na5O19P5
  1
1
EC50 = 13000 nM
 Bioactivity Info 
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CP0486236
 Compound Info 
5'-O-[(R)-HYDROXY(THIOPHOSPHONOOXY)PHOSPHORYL]ADENOSINE
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C10H15N5O9P2S
  1
1
EC50 = 32700 nM
 Bioactivity Info 
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CP0847499
 Compound Info 
sodium bis(((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)oxidophosphoryl)methyl)diphosphonate
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C22H28N10Na4O17P4
  1
1
EC50 >= 40000 nM
 Bioactivity Info 
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CP0032210
 Compound Info 
4-(4-piperidin-4-ylphenyl)-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid
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C29H24F3NO2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0853650
 Compound Info 
8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino-3,1-(4-fluorophenylene)carbonylimino]]bis[naphthalene-1,3,5-trisulfonic acid]hexasodiumsalt
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C49H28F2N6Na6O23S6
  1
1
Ki = 44.67 nM
 Bioactivity Info 
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CP0853180
 Compound Info 
8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino-3,1-(4-(methoxyphenylene)carbonylimino]]bis[naphthalene-1,3,5-trisulfonic acid]hexasodium salt
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C51H34N6Na6O25S6
  1
1
Ki = 75.86 nM
 Bioactivity Info 
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CP0853179
 Compound Info 
8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino-3,1-(4-chlorophenylene)carbonylimino]]bis[naphthalene-1,3,5-trisulfonic acid]hexasodium salt
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C49H28Cl2N6Na6O23S6
  1
1
Ki = 107.15 nM
 Bioactivity Info 
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CP0052205
 Compound Info 
5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino)]tris[1,3-benzenesulfonate analogue
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C51H40N6O23S6
  2
1
Ki = 112.2 nM
 Bioactivity Info 
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2
Ki = 302 nM
 Bioactivity Info 
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CP0911176
 Compound Info 
hexasodium 8-[[4-phenyl-3-[[3-[[3-[[2-phenyl-5-[(4,6,8-trisulfonato-1-naphthyl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonate
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C61H38N6Na6O23S6
  1
1
Ki = 302 nM
 Bioactivity Info 
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CP0853177
 Compound Info 
8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino-3,1-(4-isopropylene)carbonylimino]]bis[naphthalene-1,3,5-trisulfonic acid]hexasodiumsalt
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C55H42N6Na6O23S6
  1
1
Ki = 446.68 nM
 Bioactivity Info 
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CP0853176
 Compound Info 
8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino-3,1-(4-ethylphenylene)-carbonylimino]]bis[naphthalene-1,3,5-trisulfonic acid]hexasodium salt
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C53H38N6Na6O23S6
  1
1
Ki = 1000 nM
 Bioactivity Info 
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CP0853181
 Compound Info 
8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino-3,1-(4-(methoxymethyl)phenylene)carbonylimino]]bis[naphthalene-1,3,5-trisulfonic acid]hexasodium salt
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C53H38N6Na6O25S6
  1
1
Ki = 2398.83 nM
 Bioactivity Info 
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CP0853648
 Compound Info 
Urea derivative
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C37H24N4Na6O21S6
  1
1
Ki = 7585.78 nM
 Bioactivity Info 
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Clinical Information about the Protein
Target 1 ( P2Y purinoceptor 11 (P2RY11) )
Target Type Discontinued Target
Disease 1 Target-related Disease  1
1 Lung cancer [ICD-11: 2C25.0]
Discontinued Drug(s) 1 Discontinued Drug  1
1 INS 316
 Drug Info 
Discontinued in Phase 3
Lung cancer