Protein Information

General Information of the Protein

Protein ID	PT03554
Protein Name	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Secondarily Protein Name	2'-phospho-ADP-ribosyl cyclase 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase 2'-phospho-cyclic-ADP-ribose transferase ADP-ribosyl cyclase 1 Cyclic ADP-ribose hydrolase 1 I-19 NIM-R5 antigen
Gene Name	CD38
Sequence	MANYEFSQVSGDRPGCRLSRKAQIGLGVGLLVLIALVVGIVVILLRPRSLLVWTGEPTTKHFSDIFLGRCLIYTQILRPEMRDQNCQEILSTFKGAFVSKNPCNITREDYAPLVKLVTQTIPCNKTLFWSKSKHLAHQYTWIQGKMFTLEDTLLGYIADDLRWCGDPSTSDMNYVSCPHWSENCPNNPITVFWKVISQKFAEDACGVVQVMLNGSLREPFYKNSTFGSVEVFSLDPNKVHKLQAWVMHDIEGASSNACSSSSLNELKMIVQKRNMIFACVDNYRPARFLQCVKNPEHPSCRLNT Show/Hide
Organism	Mus musculus, Mouse
Protein Classification	Enzyme
Function	Synthesizes the second messengers cyclic ADP-ribose (cADPR) and nicotinate-adenine dinucleotide phosphate (NAADP), the former a second messenger for glucose-induced insulin secretion, the latter a Ca(2+) mobilizer (PubMed:11829748). Also has cADPR hydrolase activity (By similarity). Show/Hide
Uniprot ID	Primary ID: P56528 Secondarily ID: Q8BFY8 Show/Hide
Ensembl ID	ENSG00000004468
Subcellular Location	Membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL001013 , CHO CGE

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0906299 Compound Info	(trans)-N-Methyl-4-((8-methyl-2-oxo-6-(thiazol-5-yl)-1,2-dihydroquinolin-4-yl)amino)cyclohexanecarboxamide Show/Hide	C21H24N4O2S	1
1	IC50 < 0.18 nM Bioactivity Info	TI LI LO TS
CP0548367 Compound Info	4-[[4-(2-methoxyethoxy)cyclohexyl]amino]-8-methyl-6-(1,3-thiazol-5-yl)-1H-quinolin-2-one Show/Hide	C22H27N3O3S	1
1	IC50 = 0.62 nM Bioactivity Info	TI LI LO TS
CP0488234 Compound Info	4-[(4-methoxycyclohexyl)amino]-8-methyl-6-(1,3-thiazol-5-yl)-1H-quinolin-2-one Show/Hide	C20H23N3O2S	1
1	IC50 = 0.65 nM Bioactivity Info	TI LI LO TS
CP0450444 Compound Info	4-[[1,8-dimethyl-2-oxo-6-(1,3-thiazol-5-yl)quinolin-4-yl]amino]-N-methylcyclohexane-1-carboxamide Show/Hide	C22H26N4O2S	1
1	IC50 = 0.78 nM Bioactivity Info	TI LI LO TS
CP0450443 Compound Info	N-methyl-4-[[2-oxo-6-(1,3-thiazol-5-yl)-1H-quinolin-4-yl]amino]cyclohexane-1-carboxamide Show/Hide	C20H22N4O2S	1
1	IC50 = 0.9 nM Bioactivity Info	TI LI LO TS
CP0482600 Compound Info	4-[(4-methoxycyclohexyl)amino]-8-methyl-6-(1,3-thiazol-5-yl)-1H-quinazolin-2-one Show/Hide	C19H22N4O2S	1
1	IC50 = 1 nM Bioactivity Info	TI LI LO TS
CP0530442 Compound Info	CHEMBL3426066 Show/Hide	C21H24N4O2S	1
1	IC50 = 1.1 nM Bioactivity Info	TI LI LO TS
CP0859087 Compound Info	4-(((trans)-4-(2-Methoxyethoxy)cyclohexyl)amino)-6-(thiazol-5-yl)quinolin-2(1H)-one Show/Hide	C21H25N3O3S	1
1	IC50 = 1.3 nM Bioactivity Info	TI LI LO TS
CP0249204 Compound Info	4-[(4-methoxycyclohexyl)amino]-1,8-dimethyl-6-(1,3-thiazol-5-yl)quinolin-2-one Show/Hide	C21H25N3O2S	1
1	IC50 = 1.4 nM Bioactivity Info	TI LI LO TS
CP0469833 Compound Info	4-[(4-methoxycyclohexyl)amino]-1-methyl-6-(1,3-thiazol-5-yl)quinolin-2-one Show/Hide	C20H23N3O2S	1
1	IC50 = 1.6 nM Bioactivity Info	TI LI LO TS
CP0555864 Compound Info	4-[[4-(2-methoxyethoxy)cyclohexyl]amino]-1,8-dimethyl-6-(1,3-thiazol-5-yl)quinolin-2-one Show/Hide	C23H29N3O3S	1
1	IC50 = 1.6 nM Bioactivity Info	TI LI LO TS
CP0188353 Compound Info	4-[[4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(1,3-thiazol-5-yl)quinolin-2-one Show/Hide	C22H27N3O3S	1
1	IC50 = 1.9 nM Bioactivity Info	TI LI LO TS
CP0528854 Compound Info	4-[(4-hydroxycyclohexyl)amino]-1-methyl-6-(1,3-thiazol-5-yl)quinolin-2-one Show/Hide	C19H21N3O2S	1
1	IC50 = 2.5 nM Bioactivity Info	TI LI LO TS
CP0389468 Compound Info	4-[[8-methoxy-6-(1,3-thiazol-5-yl)quinazolin-4-yl]amino]benzamide Show/Hide	C19H15N5O2S	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0400543 Compound Info	4-(3-chloro-4-fluoroanilino)-8-methyl-6-(1,3-thiazol-5-yl)-1H-quinazolin-2-one Show/Hide	C18H12ClFN4OS	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0566856 Compound Info	8-methyl-4-(oxan-4-ylamino)-6-(1,3-thiazol-5-yl)-1H-quinolin-2-one Show/Hide	C18H19N3O2S	1
1	IC50 = 4.5 nM Bioactivity Info	TI LI LO TS
CP0414620 Compound Info	1-ethyl-4-[[4-(2-methoxyethoxy)cyclohexyl]amino]-6-(1,3-thiazol-5-yl)quinolin-2-one Show/Hide	C23H29N3O3S	1
1	IC50 = 5.2 nM Bioactivity Info	TI LI LO TS
CP0400580 Compound Info	1,8-dimethyl-4-(oxan-4-ylamino)-6-(1,3-thiazol-5-yl)quinolin-2-one Show/Hide	C19H21N3O2S	1
1	IC50 = 6 nM Bioactivity Info	TI LI LO TS
CP0414619 Compound Info	4-[[1-ethyl-2-oxo-6-(1,3-thiazol-5-yl)quinolin-4-yl]amino]-N-methylcyclohexane-1-carboxamide Show/Hide	C22H26N4O2S	1
1	IC50 = 6.1 nM Bioactivity Info	TI LI LO TS
CP0448226 Compound Info	N-(4-methylcyclohexyl)-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C18H20N4S	1
1	IC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0489213 Compound Info	4-[[2,8-dimethyl-6-(1,3-thiazol-5-yl)quinazolin-4-yl]amino]-N-methylcyclohexane-1-carboxamide Show/Hide	C21H25N5OS	1
1	IC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0400544 Compound Info	4-[[4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(1,3-thiazol-5-yl)quinazolin-2-one Show/Hide	C21H26N4O3S	1
1	IC50 = 8 nM Bioactivity Info	TI LI LO TS
CP0489212 Compound Info	4-[(4-methoxycyclohexyl)amino]-1-methyl-6-(1,3-thiazol-5-yl)quinazolin-2-one Show/Hide	C19H22N4O2S	1
1	IC50 = 8 nM Bioactivity Info	TI LI LO TS
CP0555863 Compound Info	4-[[6-(1,3-thiazol-5-yl)-8-(trifluoromethyl)quinazolin-4-yl]amino]benzamide Show/Hide	C19H12F3N5OS	1
1	IC50 = 8 nM Bioactivity Info	TI LI LO TS
CP0409957 Compound Info	N-(3-chloro-4-fluorophenyl)-8-methoxy-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C18H12ClFN4OS	1
1	IC50 = 9 nM Bioactivity Info	TI LI LO TS
CP0451644 Compound Info	4-[[6-(1,3-thiazol-5-yl)quinazolin-4-yl]amino]cyclohexane-1-carboxamide Show/Hide	C18H19N5OS	1
1	IC50 = 9 nM Bioactivity Info	TI LI LO TS
CP0409985 Compound Info	N-(3-chloro-4-fluorophenyl)-8-methyl-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C18H12ClFN4S	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0481582 Compound Info	N-[(1S,2S)-2-methylcyclohexyl]-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C18H20N4S	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0482601 Compound Info	4-(oxan-4-ylamino)-6-(1,3-thiazol-5-yl)-1H-quinolin-2-one Show/Hide	C17H17N3O2S	1
1	IC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0415308 Compound Info	N-[(1S,2R)-2-methylcyclohexyl]-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C18H20N4S	1
1	IC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0482651 Compound Info	N-ethyl-4-[[6-(1,3-thiazol-5-yl)quinazolin-4-yl]amino]cyclohexane-1-carboxamide Show/Hide	C20H23N5OS	1
1	IC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0530439 Compound Info	N-cyclopentyl-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C16H16N4S	1
1	IC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0415310 Compound Info	N-[4-(1,3-oxazol-5-yl)phenyl]-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C20H13N5OS	1
1	IC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0489207 Compound Info	N-cyclohexyl-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C17H18N4S	1
1	IC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0241206 Compound Info	1-methyl-4-(oxan-4-ylamino)-6-(1,3-thiazol-5-yl)quinolin-2-one Show/Hide	C18H19N3O2S	1
1	IC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0551548 Compound Info	N-(3-methylcyclohexyl)-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C18H20N4S	1
1	IC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0487036 Compound Info	N-(3-methylphenyl)-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C18H14N4S	1
1	IC50 = 17 nM Bioactivity Info	TI LI LO TS
CP0469830 Compound Info	N-(3-chloro-4-fluorophenyl)-6-(1,3-thiazol-5-yl)quinolin-4-amine Show/Hide	C18H11ClFN3S	1
1	IC50 = 19 nM Bioactivity Info	TI LI LO TS
CP0498968 Compound Info	N-(3-chlorophenyl)-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C17H11ClN4S	1
1	IC50 = 19 nM Bioactivity Info	TI LI LO TS
CP0481563 Compound Info	N-(4-methylphenyl)-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C18H14N4S	1
1	IC50 = 22 nM Bioactivity Info	TI LI LO TS
CP0451648 Compound Info	N-pyridin-4-yl-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C16H11N5S	1
1	IC50 = 24 nM Bioactivity Info	TI LI LO TS
CP0546317 Compound Info	4-[[6-(1,3-thiazol-5-yl)quinazolin-4-yl]amino]benzamide Show/Hide	C18H13N5OS	1
1	IC50 = 24 nM Bioactivity Info	TI LI LO TS
CP0415307 Compound Info	4-[[6-(1,3-thiazol-5-yl)quinazolin-4-yl]amino]cyclohexan-1-ol Show/Hide	C17H18N4OS	1
1	IC50 = 25 nM Bioactivity Info	TI LI LO TS
CP0428758 Compound Info	N-(4-chlorophenyl)-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C17H11ClN4S	1
1	IC50 = 26 nM Bioactivity Info	TI LI LO TS
CP0482652 Compound Info	1-[4-[[6-(1,3-thiazol-5-yl)quinazolin-4-yl]amino]phenyl]pyrrolidin-2-one Show/Hide	C21H17N5OS	1
1	IC50 = 26 nM Bioactivity Info	TI LI LO TS
CP0546318 Compound Info	N-(4-imidazol-1-ylphenyl)-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C20H14N6S	1
1	IC50 = 26 nM Bioactivity Info	TI LI LO TS
CP0451647 Compound Info	4-[[6-(1,3-thiazol-5-yl)quinazolin-4-yl]amino]benzenesulfonamide Show/Hide	C17H13N5O2S2	1
1	IC50 = 27 nM Bioactivity Info	TI LI LO TS
CP0469832 Compound Info	N-(3-fluorophenyl)-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C17H11FN4S	1
1	IC50 = 31 nM Bioactivity Info	TI LI LO TS
CP0481583 Compound Info	N-(3-methylsulfonylphenyl)-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C18H14N4O2S2	1
1	IC50 = 31 nM Bioactivity Info	TI LI LO TS
CP0489209 Compound Info	N-cyclobutyl-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C15H14N4S	1
1	IC50 = 31 nM Bioactivity Info	TI LI LO TS
CP0566803 Compound Info	N-(4-fluorophenyl)-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C17H11FN4S	1
1	IC50 = 31 nM Bioactivity Info	TI LI LO TS
CP0428757 Compound Info	N-(3-chloro-4-fluorophenyl)-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C17H10ClFN4S	1
1	IC50 = 32 nM Bioactivity Info	TI LI LO TS
CP0428755 Compound Info	4-[[6-(1,3-thiazol-5-yl)quinazolin-4-yl]amino]piperidine-1-carboxamide Show/Hide	C17H18N6OS	1
1	IC50 = 34 nM Bioactivity Info	TI LI LO TS
CP0481580 Compound Info	(1R,3R)-3-[[6-(1,3-thiazol-5-yl)quinazolin-4-yl]amino]cyclohexane-1-carboxamide Show/Hide	C18H19N5OS	1
1	IC50 = 37 nM Bioactivity Info	TI LI LO TS
CP0547406 Compound Info	N-methyl-4-[[8-methyl-6-(1,3-thiazol-5-yl)-2-(trifluoromethyl)quinazolin-4-yl]amino]cyclohexane-1-carboxamide Show/Hide	C21H22F3N5OS	1
1	IC50 = 37 nM Bioactivity Info	TI LI LO TS
CP0451643 Compound Info	4-[[6-(1,3-thiazol-5-yl)quinazolin-4-yl]amino]cyclohexane-1-carboxylic acid Show/Hide	C18H18N4O2S	1
1	IC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0389610 Compound Info	6-(1,3-thiazol-5-yl)-N-[3-(trifluoromethyl)phenyl]quinazolin-4-amine Show/Hide	C18H11F3N4S	1
1	IC50 = 42 nM Bioactivity Info	TI LI LO TS
CP0508019 Compound Info	N-(oxan-3-yl)-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C16H16N4OS	1
1	IC50 = 45 nM Bioactivity Info	TI LI LO TS
CP0508021 Compound Info	N-(2-fluorophenyl)-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C17H11FN4S	1
1	IC50 = 45 nM Bioactivity Info	TI LI LO TS
CP0469831 Compound Info	N-phenyl-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C17H12N4S	1
1	IC50 = 46 nM Bioactivity Info	TI LI LO TS
CP0549241 Compound Info	N-[4-[[6-(1,3-thiazol-5-yl)quinazolin-4-yl]amino]phenyl]methanesulfonamide Show/Hide	C18H15N5O2S2	1
1	IC50 = 50 nM Bioactivity Info	TI LI LO TS
CP0508020 Compound Info	N-(oxan-4-yl)-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C16H16N4OS	1
1	IC50 = 51 nM Bioactivity Info	TI LI LO TS
CP0451646 Compound Info	N-(2-chlorophenyl)-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C17H11ClN4S	1
1	IC50 = 58 nM Bioactivity Info	TI LI LO TS
CP0428760 Compound Info	N-pyridin-3-yl-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C16H11N5S	1
1	IC50 = 59 nM Bioactivity Info	TI LI LO TS
CP0508022 Compound Info	N-(2-methylphenyl)-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C18H14N4S	1
1	IC50 = 65 nM Bioactivity Info	TI LI LO TS
CP0530441 Compound Info	N-tert-butyl-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C15H16N4S	1
1	IC50 = 66 nM Bioactivity Info	TI LI LO TS
CP0397784 Compound Info	N-methyl-4-[[2-methyl-6-(1,3-thiazol-5-yl)-8-(trifluoromethyl)quinazolin-4-yl]amino]cyclohexane-1-carboxamide Show/Hide	C21H22F3N5OS	1
1	IC50 = 72 nM Bioactivity Info	TI LI LO TS
CP0489210 Compound Info	N-propan-2-yl-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C14H14N4S	1
1	IC50 = 75 nM Bioactivity Info	TI LI LO TS
CP0478178 Compound Info	1-[4-[[6-(1,3-thiazol-5-yl)quinazolin-4-yl]amino]cyclohexyl]pyrrolidin-2-one Show/Hide	C21H23N5OS	1
1	IC50 = 77 nM Bioactivity Info	TI LI LO TS
CP0549996 Compound Info	N-(1,1-dioxothian-4-yl)-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C16H16N4O2S2	1
1	IC50 = 85 nM Bioactivity Info	TI LI LO TS
CP0428756 Compound Info	N-(oxolan-3-yl)-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C15H14N4OS	1
1	IC50 = 86 nM Bioactivity Info	TI LI LO TS
CP0546319 Compound Info	N-pyridin-2-yl-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C16H11N5S	1
1	IC50 = 97 nM Bioactivity Info	TI LI LO TS
CP0481562 Compound Info	N-(4-methylsulfonylcyclohexyl)-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C18H20N4O2S2	1
1	IC50 = 135 nM Bioactivity Info	TI LI LO TS
CP0555862 Compound Info	N-(3-chloro-4-fluorophenyl)-6-(1,3-thiazol-5-yl)-8-(trifluoromethyl)quinazolin-4-amine Show/Hide	C18H9ClF4N4S	1
1	IC50 = 139 nM Bioactivity Info	TI LI LO TS
CP0488087 Compound Info	N-cyclopropyl-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C14H12N4S	1
1	IC50 = 144 nM Bioactivity Info	TI LI LO TS
CP0566855 Compound Info	N-ethyl-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C13H12N4S	1
1	IC50 = 145 nM Bioactivity Info	TI LI LO TS
CP0414621 Compound Info	4-amino-1-methyl-6-(1,3-thiazol-5-yl)quinolin-2-one Show/Hide	C13H11N3OS	1
1	IC50 = 163 nM Bioactivity Info	TI LI LO TS
CP0489211 Compound Info	2-[[6-(1,3-thiazol-5-yl)quinazolin-4-yl]amino]ethanol Show/Hide	C13H12N4OS	1
1	IC50 = 189 nM Bioactivity Info	TI LI LO TS
CP0489208 Compound Info	4-(3-chloro-4-fluoroanilino)-6-(1,3-thiazol-5-yl)quinoline-3-carboxamide Show/Hide	C19H12ClFN4OS	1
1	IC50 = 205 nM Bioactivity Info	TI LI LO TS
CP0498967 Compound Info	N-piperidin-4-yl-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C16H17N5S	1
1	IC50 = 275 nM Bioactivity Info	TI LI LO TS
CP0549240 Compound Info	N-piperidin-3-yl-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C16H17N5S	1
1	IC50 = 296 nM Bioactivity Info	TI LI LO TS
CP0478179 Compound Info	N-(2-methoxyethyl)-6-(1,3-thiazol-5-yl)quinazolin-4-amine Show/Hide	C14H14N4OS	1
1	IC50 = 298 nM Bioactivity Info	TI LI LO TS
CP0548365 Compound Info	4-[[6-(1,3-thiazol-5-yl)quinazolin-4-yl]amino]cyclohexane-1-carboxylic acid Show/Hide	C18H18N4O2S	1
1	IC50 = 459 nM Bioactivity Info	TI LI LO TS
CP0547405 Compound Info	1-[4-[[6-(1,3-thiazol-5-yl)quinazolin-4-yl]amino]cyclohexyl]pyrrolidin-2-one Show/Hide	C21H23N5OS	1
1	IC50 = 1110 nM Bioactivity Info	TI LI LO TS

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han