General Information of the Protein
Protein ID
PT03440
Protein Name
Solute carrier family 2, facilitated glucose transporter member 4
Secondarily
Protein Name
Glucose transporter type 4
insulin-responsive
Gene Name
SLC2A4
Secondarily
Gene Name
GLUT4
Sequence
MPSGFQQIGSEDGEPPQQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETWLGRQGPEGPSSIPPGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGLANAAASYEMLILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILIAQVLGLESLLGTASLWPLLLGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPARKSLKRLTGWADVSGVLAELKDEKRKLERERPLSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFETAGVGQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTSNFIIGMGFQYVAEAMGPYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQISAAFHRTPSLLEQEVKPSTELEYLGPDEND
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Organism
Homo sapiens, Human
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC02 family of hexose and sugar alcohol transporters
Function
Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell.
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Uniprot ID
Primary ID:
P14672

Secondarily ID:
Q05BQ3
Q14CX2
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Ensembl ID
ENSG00000181856
HGNC ID
HGNC:11009
Subcellular Location
Cell membrane
Endomembrane system
Cytoplasm
Perinuclear region
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0861352
 Compound Info 
(S)-3-(2-bromophenyl)-2-(2-(4-methoxyphenyl)acetamido)-N-((S)-1-phenylethyl)propanamide
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C26H27BrN2O3
  1
1
IC50 = 90 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0953482
 Compound Info 
(S)-3-(4-fluorophenyl)-2-(2-(3-hydroxyphenyl)acetamido)-N-((S)-1-phenylethyl)propanamide
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C25H25FN2O3
  1
1
IC50 = 195 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0031042
 Compound Info 
4-N-[1-[(4-cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)pyrazol-4-yl]-7-fluoroquinoline-2,4-dicarboxamide
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C24H16F4N6O2
  1
1 IC50 ~ 270 nM
Clinical Information about the Protein
Target 1 ( Glucose transporter type 4 (SLC2A4) )
Target Type Clinical trial Target
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT07092 Solute carrier family 2, facilitated glucose transporter member 4 Mus musculus, Mouse
 Protein Info