General Information of the Protein
Protein ID
PT03403
Protein Name
Ectonucleoside triphosphate diphosphohydrolase 1
Secondarily
Protein Name
ATP diphosphohydrolase
Ecto-ATP diphosphohydrolase 1
Ecto-apyrase
Lymphoid cell activation antigen
Nucleoside triphosphate diphosphohydrolase 1
Gene Name
ENTPD1
Secondarily
Gene Name
CD39
Sequence
MEDTKESNVKTFCSKNILAILGFSSIIAVIALLAVGLTQNKALPENVKYGIVLDAGSSHTSLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKVNEIGIYLTDCMERAREVIPRSQHQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWITINYLLGKFSQKTRWFSIVPYETNNQETFGALDLGGASTQVTFVPQNQTIESPDNALQFRLYGKDYNVYTHSFLCYGKDQALWQKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTPCTKRFEMTLPFQQFEIQGIGNYQQCHQSILELFNTSYCPYSQCAFNGIFLPPLQGDFGAFSAFYFVMKFLNLTSEKVSQEKVTEMMKKFCAQPWEEIKTSYAGVKEKYLSEYCFSGTYILSLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNMIPAEQPLSTPLSHSTYVFLMVLFSLVLFTVAIIGLLIFHKPSYFWKDMV
    Show/Hide
Organism
Homo sapiens, Human
Protein Classification
Enzyme
Function
Catalyzes the hydrolysis of both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates and participates in the regulation of extracellular levels of nucleotides (PubMed:8955160, PubMed:8529670, PubMed:8996251, PubMed:8626624) (Probable). By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow (PubMed:8955160, PubMed:8996251).
    Show/Hide
Uniprot ID
Primary ID:
P49961

Secondarily ID:
A9Z1X8
B4DWB9
B4E1X1
B7Z599
G3XAF6
Q5T561
Q5T562
Q86VV3
Q9UQQ9
Q9Y3Q9
    Show/Hide
Ensembl ID
ENSG00000138185
HGNC ID
HGNC:3363
Subcellular Location
Membrane
Membrane
Caveola
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0472500
 Compound Info 
[(2R,3S,4R,5R)-5-[6-chloro-4-(cyclopentylamino)pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxyoxolan-2-yl]methoxymethylphosphonic acid
   Show/Hide
C16H23ClN5O7P
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0384426
 Compound Info 
4-[[5-[7-chloro-3-(1H-indazol-6-yl)benzotriazol-5-yl]pyrazol-1-yl]methyl]benzonitrile
   Show/Hide
C24H15ClN8
  1
1
IC50 > 20000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Protein
Target 1 ( Ectonucleoside triphosphate diphosphohydrolase 1 (CD39) )
Target Type Clinical trial Target