General Information of the Protein
Protein ID
PT03161
Protein Name
Histamine H1 receptor
Gene Name
HRH1
Sequence
MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAPTSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSLPSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSEDEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFPITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP
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Organism
Cavia porcellus, Guinea pig
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Histamine receptor
Function
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
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Uniprot ID
P31389
Ensembl ID
ENSG00000196639
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0377744
 Compound Info 
1-[(4-chlorophenyl)methyl]-3-[5-(1H-imidazol-4-yl)pentyl]thiourea
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C16H21ClN4S
  1
1
Ki = 1584.89 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0847415
 Compound Info 
1-[5-(1H-Imidazol-4-yl)-pentyl]-3-phenyl-thiourea
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C15H20N4S
  1
1
Ki = 2511.89 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0849878
 Compound Info 
1-[5-(1H-Imidazol-4-yl)-pentyl]-3-phenethyl-thiourea
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C17H24N4S
  1
1
Ki = 3162.28 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0885970
 Compound Info 
1-[5-(1H-Imidazol-4-yl)-pentyl]-3-propyl-thiourea
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C12H22N4S
  1
1
Ki = 3162.28 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0849842
 Compound Info 
1-Benzyl-3-[5-(1H-imidazol-4-yl)-pentyl]-thiourea
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C16H22N4S
  1
1
Ki = 3981.07 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0448109
 Compound Info 
1-cyclohexyl-3-[5-(1H-imidazol-4-yl)pentyl]thiourea
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C15H26N4S
  1
1
Ki = 7943.28 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0432955
 Compound Info 
1-[5-(1H-imidazol-4-yl)pentyl]-3-propan-2-ylthiourea
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C12H22N4S
  1
1
Ki = 12589.25 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0448304
 Compound Info 
3-ethyl-1-[5-(1H-imidazol-4-yl)pentyl]thiourea
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C11H20N4S
  1
1
Ki = 15848.93 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0377130
 Compound Info 
1-[5-(1H-imidazol-5-yl)pentyl]-3-methylthiourea
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C10H18N4S
  1
1
Ki = 19952.62 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0036920
 Compound Info 
2-(1H-imidazol-4-yl)ethan-1-amine
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C5H9N3
  1
1 EC50 = 162.18 nM