General Information of the Protein
Protein ID
PT03142
Protein Name
Vascular endothelial growth factor A, long form
Secondarily
Protein Name
Vascular permeability factor
Gene Name
VEGFA
Secondarily
Gene Name
VEGF
Sequence
MTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEPQPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASETMNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
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Organism
Homo sapiens, Human
Protein Classification
Secreted protein
Function
Participates in the induction of key genes involved in the response to hypoxia and in the induction of angiogenesis such as HIF1A (PubMed:35455969). Involved in protecting cells from hypoxia-mediated cell death (By similarity).
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Uniprot ID
Primary ID:
P15692

Secondarily ID:
B5BU86
H0Y2S8
H0Y407
H0Y414
H0Y462
H0Y8N2
H3BLW7
O60720
O75875
Q074Z4
Q16889
Q5UB46
Q6P0P5
Q96KJ0
Q96L82
Q96NW5
Q9H1W8
Q9H1W9
Q9UH58
Q9UL23
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Ensembl ID
ENSG00000112715
HGNC ID
HGNC:12680
Subcellular Location
Cytoplasm
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0099539
 Compound Info 
US11426393, Compound Table XV.17
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C15H14ClN3O3
  1
1
EC50 = 1400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0064970
 Compound Info 
US11426393, Compound Table XV.16
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C15H13ClN2O4
  1
1
EC50 = 3300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0164653
 Compound Info 
US8598210, Table XV, 8
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C15H11N3O4
  1
1
EC50 = 4300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0060213
 Compound Info 
US11426393, Compound Table XV.11
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C14H11ClN2O4
  1
1
EC50 = 7600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0109269
 Compound Info 
US11426393, Compound Table XV.7
   Show/Hide
C15H13ClN2O4
  1
1
EC50 = 7700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0148616
 Compound Info 
US11426393, Compound Table XV.6
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C16H16N2O4
  1
1
EC50 = 8200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0107872
 Compound Info 
US11426393, Compound Table XV.1
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C15H13ClN2O4
  1
1
EC50 = 9900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0076777
 Compound Info 
US11426393, Compound Table XV.13
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C17H18N2O4
  1
1
EC50 = 15000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0066265
 Compound Info 
US11426393, Compound Table XV.4
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C15H14N2O4
  1
1
EC50 = 42100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0226971
 Compound Info 
US11426393, Compound Table XV.21
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C16H15N3O5
  1
1
EC50 = 50100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0099562
 Compound Info 
US11426393, Compound Table XV.5
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C16H15NO4
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0105696
 Compound Info 
US8598210, Table XV, 19
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C16H14N6O4
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0122947
 Compound Info 
US8598210, Table XV, 24
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C15H12N6O4
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0141223
 Compound Info 
US11426393, Compound Table XV.2
   Show/Hide
C15H13ClN2O4
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0199997
 Compound Info 
US11426393, Compound Table XV.14
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C14H11FN2O4
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0257735
 Compound Info 
US8598210, Table XV, 20
   Show/Hide
C15H11N3O4
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0257737
 Compound Info 
US8598210, Table XV, 18
   Show/Hide
C16H13N3O4
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0261239
 Compound Info 
US8598210, Table XV, 3
   Show/Hide
C16H13N3O4
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0342923
 Compound Info 
US11426393, Compound Table XV.15
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C17H18N2O5
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0369799
 Compound Info 
US11426393, Compound Table XV.23
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C19H19N3O5
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0520375
 Compound Info 
US11426393, Compound Table XV.22
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C20H21N3O5
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0140226
 Compound Info 
US10562854, No. E33
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C16H18N2O6S
  1
1
IC50 = 2100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0242973
 Compound Info 
US10562854, No. F3
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C12H10ClNO2
  1
1
IC50 = 7400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0092311
 Compound Info 
US10562854, No. B9
   Show/Hide
C24H27N3O2
  1
1
IC50 = 12600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0054156
 Compound Info 
US10562854, No. A41
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C22H28ClN3O4
  1
1
IC50 = 16600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0093595
 Compound Info 
US10562854, No. D14
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C21H22ClN5O4S
  1
1
IC50 = 19000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0093596
 Compound Info 
US10562854, No. C14
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C21H22N2O2
  1
1
IC50 = 20600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0170125
 Compound Info 
US10562854, No. D10
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C23H31N3O4S
  1
1
IC50 = 27000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0118342
 Compound Info 
US10562854, No. C17
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C20H26N2O2
  1
1
IC50 = 27400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0349695
 Compound Info 
US10562854, No. A18
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C20H26N2O3
  1
1
IC50 = 29200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0097787
 Compound Info 
US10562854, No. C1
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C20H19ClN2O2
  1
1
IC50 = 42000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0351548
 Compound Info 
US10562854, No. C35
   Show/Hide
C19H22N4O2
  1
1
IC50 = 42500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0118343
 Compound Info 
US10562854, No. B5
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C19H24N2O3
  1
1
IC50 = 53000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0242971
 Compound Info 
US10562854, No. C33
   Show/Hide
C16H20N2O2S
  1
1
IC50 = 53000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0173889
 Compound Info 
US10562854, No. C19
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C19H23N3O3
  1
1
IC50 = 62900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0351549
 Compound Info 
US10562854, No. B14
   Show/Hide
C21H22ClN5O2
  1
1
IC50 = 78000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0097789
 Compound Info 
US10562854, No. F2
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C12H10ClNO2
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0140226
 Compound Info 
US10562854, No. E33
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C16H18N2O6S
  1
1 IC50 = 2100 nM
CP0242973
 Compound Info 
US10562854, No. F3
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C12H10ClNO2
  1
1 IC50 = 7400 nM
CP0092311
 Compound Info 
US10562854, No. B9
   Show/Hide
C24H27N3O2
  1
1 IC50 = 12600 nM
CP0054156
 Compound Info 
US10562854, No. A41
   Show/Hide
C22H28ClN3O4
  1
1 IC50 = 16600 nM
CP0093595
 Compound Info 
US10562854, No. D14
   Show/Hide
C21H22ClN5O4S
  1
1 IC50 = 19000 nM
CP0093596
 Compound Info 
US10562854, No. C14
   Show/Hide
C21H22N2O2
  1
1 IC50 = 20600 nM
CP0170125
 Compound Info 
US10562854, No. D10
   Show/Hide
C23H31N3O4S
  1
1 IC50 = 27000 nM
CP0118342
 Compound Info 
US10562854, No. C17
   Show/Hide
C20H26N2O2
  1
1 IC50 = 27400 nM
CP0349695
 Compound Info 
US10562854, No. A18
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C20H26N2O3
  1
1 IC50 = 29200 nM
CP0097787
 Compound Info 
US10562854, No. C1
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C20H19ClN2O2
  1
1 IC50 = 42000 nM
CP0351548
 Compound Info 
US10562854, No. C35
   Show/Hide
C19H22N4O2
  1
1 IC50 = 42500 nM
CP0242971
 Compound Info 
US10562854, No. C33
   Show/Hide
C16H20N2O2S
  1
1 IC50 = 53000 nM
CP0173889
 Compound Info 
US10562854, No. C19
   Show/Hide
C19H23N3O3
  1
1 IC50 = 62900 nM
CP0351549
 Compound Info 
US10562854, No. B14
   Show/Hide
C21H22ClN5O2
  1
1 IC50 = 78000 nM
CP0097789
 Compound Info 
US10562854, No. F2
   Show/Hide
C12H10ClNO2
  1
1 IC50 > 100000 nM
Clinical Information about the Protein
Target 1 ( Vascular endothelial growth factor A (VEGFA) )
Target Type Successful Target
Disease 2 Target-related Diseases  2
1 Non-small-cell lung cancer [ICD-11: 2C25.Y]
2 Breast cancer [ICD-11: 2C60-2C65]
Clinical Trial Drug(s) 2 Clinical Trial Drugs  2
1 Avastin+/-Tarceva
 Drug Info 
Phase 3
Non-small-cell lung cancer
2 Bevacizumab + Trastuzumab
 Drug Info 
Phase 3
Breast cancer
Target 2 ( VEGF A165 messenger RNA (VEGF A165 mRNA) )
Target Type Literature-reported Target
Target 3 ( VEGF messenger RNA (VEGF mRNA) )
Target Type Literature-reported Target