General Information of the Protein
Protein ID
PT03019
Protein Name
Hepatocyte growth factor activator
Gene Name
HGFAC
Sequence
MGRWAWVPSPWPPPGLGPFLLLLLLLLLLPRGFQPQPGGNRTESPEPNATATPAIPTILVTSVTSETPATSAPEAEGPQSGGLPPPPRAVPSSSSPQAQALTEDGRPCRFPFRYGGRMLHACTSEGSAHRKWCATTHNYDRDRAWGYCVEATPPPGGPAALDPCASGPCLNGGSCSNTQDPQSYHCSCPRAFTGKDCGTEKCFDETRYEYLEGGDRWARVRQGHVEQCECFGGRTWCEGTRHTACLSSPCLNGGTCHLIVATGTTVCACPPGFAGRLCNIEPDERCFLGNGTGYRGVASTSASGLSCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYVVKDSALSWEYCRLEACESLTRVQLSPDLLATLPEPASPGRQACGRRHKKRTFLRPRIIGGSSSLPGSHPWLAAIYIGDSFCAGSLVHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFNRTTDVTQTFGIEKYIPYTLYSVFNPSDHDLVLIRLKKKGDRCATRSQFVQPICLPEPGSTFPAGHKCQIAGWGHLDENVSGYSSSLREALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGGPLACEKNGVAYLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRIRPPRRLVAPS
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Protease
>
Serine protease
>
Serine protease PA clan
>
Serine protease S1A subfamily
Function
Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form.
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Uniprot ID
Primary ID:
Q04756

Secondarily ID:
Q14726
Q2M1W7
Q53X47
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Ensembl ID
ENSG00000109758
HGNC ID
HGNC:4894
Subcellular Location
Secreted
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0082712
 Compound Info 
4-Guanidino-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester
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C19H17N5O2
  2
1
IC50 = 150 nM
 Bioactivity Info 
   TI
   LI
   LO
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2
Ki = 25 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0504742
 Compound Info 
(2-chloro-4-nitrophenyl) 4-(diaminomethylideneamino)benzoate
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C14H11ClN4O4
  1
1
IC50 = 300 nM
 Bioactivity Info 
   TI
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   LO
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CP0488678
 Compound Info 
methyl 6-[4-(diaminomethylideneamino)benzoyl]oxynaphthalene-2-carboxylate
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C20H17N3O4
  1
1
IC50 = 600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0040568
 Compound Info 
(4-nitrophenyl) 4-(diaminomethylideneamino)benzoate
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C14H12N4O4
  1
1
IC50 = 820 nM
 Bioactivity Info 
   TI
   LI
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   TS
CP0078932
 Compound Info 
(4-methoxycarbonylphenyl) 4-(diaminomethylideneamino)benzoate
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C16H15N3O4
  1
1
IC50 = 1100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0535287
 Compound Info 
(3-nitrophenyl) 4-(diaminomethylideneamino)benzoate
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C14H12N4O4
  1
1
IC50 = 3000 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0504743
 Compound Info 
(4-carbamoylphenyl) 4-(diaminomethylideneamino)benzoate
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C15H14N4O3
  1
1
IC50 = 6800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0234575
 Compound Info 
US9199927, camostat
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C20H22N4O5
  1
1
IC50 = 32000 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0522205
 Compound Info 
methyl 6-[[4-(diaminomethylideneamino)phenyl]sulfonylamino]naphthalene-2-carboxylate
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C19H18N4O4S
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
   LI
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   TS
CP0523213
 Compound Info 
4-(diaminomethylideneamino)-N-phenylbenzamide
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C14H14N4O
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0530930
 Compound Info 
N-[4-(diaminomethylideneamino)phenyl]benzamide
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C14H14N4O
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
   LI
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   TS
CP0535286
 Compound Info 
2-[4-[(4-methylphenyl)sulfonylamino]phenyl]guanidine
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C14H16N4O2S
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0116398
 Compound Info 
3-[(2S)-3-oxo-3-[4-(piperidin-4-ylcarbonyl)piperazin-1-yl]-2-{[2,4,6-tris(propan-2-yl)benzene]sulfonamido}propyl]benzene-1-carboximidamide
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C35H52N6O4S
  1
1
Ki = 5500 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0152554
 Compound Info 
2-(4-carbamimidoylanilino)-2-(7-ethyl-3-methyl-1-benzofuran-5-yl)-N-(1-methylimidazol-4-yl)sulfonylacetamide
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C24H26N6O4S
  1
1
Ki = 7100 nM
 Bioactivity Info 
   TI
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CP0206875
 Compound Info 
3-[(2S)-2-(naphthalen-2-ylsulfonylamino)-3-oxo-3-(4-phenylpiperidin-1-yl)propyl]benzenecarboximidamide
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C31H32N4O3S
  1
1
Ki = 10100 nM
 Bioactivity Info 
   TI
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CP0089706
 Compound Info 
N-benzyl-4-[(2S)-3-(3-carbamimidoylphenyl)-2-(naphthalen-2-ylsulfonylamino)propanoyl]piperazine-1-carboxamide
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C32H34N6O4S
  1
1
Ki = 14000 nM
 Bioactivity Info 
   TI
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CP0294929
 Compound Info 
N-[(4-bromophenyl)methyl]-4-[(2S)-3-(3-carbamimidoylphenyl)-2-(naphthalen-2-ylsulfonylamino)propanoyl]piperazine-1-carboxamide
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C32H33BrN6O4S
  1
1
Ki = 16200 nM
 Bioactivity Info 
   TI
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CP0186442
 Compound Info 
3-amidinophenylalanine deriv., 31
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C36H54N8O4S
  1
1
Ki = 17000 nM
 Bioactivity Info 
   TI
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CP0185167
 Compound Info 
3-[(2S)-2-(naphthalen-2-ylsulfonylamino)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl]benzenecarboximidamide
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C30H31N5O3S
  1
1
Ki = 18200 nM
 Bioactivity Info 
   TI
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CP0116396
 Compound Info 
3-[(2S)-2-[(4-methylphenyl)sulfonylamino]-3-oxo-3-(4-phenylpiperidin-1-yl)propyl]benzenecarboximidamide
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C28H32N4O3S
  1
1
Ki = 20000 nM
 Bioactivity Info 
   TI
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CP0206877
 Compound Info 
3-[(2S)-3-oxo-3-(4-phenylpiperazin-1-yl)-2-[[2,4,6-tri(propan-2-yl)phenyl]sulfonylamino]propyl]benzenecarboximidamide
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C35H47N5O3S
  1
1
Ki = 22200 nM
 Bioactivity Info 
   TI
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CP0052965
 Compound Info 
benzyl 4-[(2S)-3-(3-carbamimidoylphenyl)-2-[(4-methylphenyl)sulfonylamino]propanoyl]piperazine-1-carboxylate
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C29H33N5O5S
  1
1
Ki > 50000 nM
 Bioactivity Info 
   TI
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CP0052968
 Compound Info 
4-[(2S)-3-(3-carbamimidoylphenyl)-2-(naphthalen-2-ylsulfonylamino)propanoyl]-N-hexylpiperazine-1-carboxamide
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C31H40N6O4S
  1
1
Ki > 50000 nM
 Bioactivity Info 
   TI
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CP0152549
 Compound Info 
benzyl N-[(3R)-1-[(2S)-3-(3-carbamimidoylphenyl)-2-(naphthalen-2-ylsulfonylamino)propanoyl]piperidin-3-yl]carbamate
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C33H35N5O5S
  1
1
Ki > 50000 nM
 Bioactivity Info 
   TI
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CP0206874
 Compound Info 
3-[(2S)-3-[4-(1-benzothiophene-3-carbonyl)piperazin-1-yl]-2-(naphthalen-2-ylsulfonylamino)-3-oxopropyl]benzenecarboximidamide
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C33H31N5O4S2
  1
1
Ki > 50000 nM
 Bioactivity Info 
   TI
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CP0334636
 Compound Info 
benzyl N-[(3S)-1-[(2S)-3-(3-carbamimidoylphenyl)-2-[(4-methylphenyl)sulfonylamino]propanoyl]piperidin-3-yl]carbamate
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C30H35N5O5S
  1
1
Ki > 50000 nM
 Bioactivity Info 
   TI
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CP0347539
 Compound Info 
4-[(2S)-3-(3-carbamimidoylphenyl)-2-[(4-methylphenyl)sulfonylamino]propanoyl]-N-(2-phenylethyl)piperazine-1-carboxamide
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C30H36N6O4S
  1
1
Ki > 50000 nM
 Bioactivity Info 
   TI
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Biochemical Assays
Compound ID Compound Name Compound Formula
CP0116398
 Compound Info 
3-[(2S)-3-oxo-3-[4-(piperidin-4-ylcarbonyl)piperazin-1-yl]-2-{[2,4,6-tris(propan-2-yl)benzene]sulfonamido}propyl]benzene-1-carboximidamide
   Show/Hide
C35H52N6O4S
  1
1 IC50 = 11000 nM
CP0294929
 Compound Info 
N-[(4-bromophenyl)methyl]-4-[(2S)-3-(3-carbamimidoylphenyl)-2-(naphthalen-2-ylsulfonylamino)propanoyl]piperazine-1-carboxamide
   Show/Hide
C32H33BrN6O4S
  1
1 IC50 = 30000 nM
CP0082712
 Compound Info 
4-Guanidino-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester
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C19H17N5O2
  1
1 Ki = 25 nM
Clinical Information about the Protein
Target 1 ( Hepatocyte growth factor activator (HGFAC) )
Target Type Literature-reported Target