General Information of the Protein
Protein ID
PT02911
Protein Name
Ectonucleoside triphosphate diphosphohydrolase 1
Secondarily
Protein Name
ATP diphosphohydrolase
Ecto-ATP diphosphohydrolase 1
Ecto-apyrase
Lymphoid cell activation antigen
Nucleoside triphosphate diphosphohydrolase 1
Gene Name
ENTPD1
Secondarily
Gene Name
Cd39
Sequence
MEDIKDSKVKRFCSKNILIILGFSSVLAVIALIAVGLTHNKPLPENVKYGIVLDAGSSHTNLYIYKWPAEKENDTGVVQLLEECQVKGPGISKYAQKTDEIAAYLAECMKMSTERIPASKQHQTPVYLGATAGMRLLRMESKQSADEVLAAVSRSLKSYPFDFQGAKIITGQEEGAYGWITINYLLGRFTQEQSWLNFISDSQKQATFGALDLGGSSTQVTFVPLNQTLEAPETSLQFRLYGTDYTVYTHSFLCYGKDQALWQKLAQDIQVSSGGILKDPCFYPGYKKVVNVSELYGTPCTKRFEKKLPFNQFQVQGTGDYEQCHQSILKFFNNSHCPYSQCAFNGVFLPPLQGSFGAFSAFYFVMDFFKKMANDSVSSQEKMTEITKNFCSKPWEEVKASYPTVKEKYLSEYCFSGTYILSLLLQGYNFTGTSWDQIHFMGKIKDSNAGWTLGYMLNLTNMIPAEQPLSPPLPHSTYISLMVLFSLVLVAMVITGLFIFSKPSYFWKEAV
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Organism
Rattus norvegicus, Rat
Protein Classification
Enzyme
>
Hydrolase
Function
Catalyzes the hydrolysis of both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates and participates in the regulation of extracellular levels of nucleotides (PubMed:9221928, PubMed:9364474, PubMed:22100451). By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow (By similarity).
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Uniprot ID
P97687
Ensembl ID
ENSG00000138185
Subcellular Location
Membrane
Membrane
Caveola
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0393064
 Compound Info 
(4-chloro-3,5-dimethylpyrazol-1-yl)-(2-methylphenyl)methanone
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C13H13ClN2O
  1
1
IC50 = 1050 nM
 Bioactivity Info 
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CP0080093
 Compound Info 
(2R)-1-(4-chloro-3,5-dimethylpyrazol-1-yl)-2-[4-(2-methylpropyl)phenyl]propan-1-one
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C18H23ClN2O
  1
1
IC50 = 1100 nM
 Bioactivity Info 
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CP0271237
 Compound Info 
(4-chloro-3,5-dimethylpyrazol-1-yl)-(3-methylphenyl)methanone
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C13H13ClN2O
  1
1
IC50 = 2300 nM
 Bioactivity Info 
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CP0393067
 Compound Info 
(3,5-dimethylpyrazol-1-yl)-(2-methylphenyl)methanone
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C13H14N2O
  1
1
IC50 = 6210 nM
 Bioactivity Info 
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CP0392815
 Compound Info 
3,5-dimethyl-4-naphthalen-2-yloxy-1H-pyrazole
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C15H14N2O
  1
1
IC50 = 9020 nM
 Bioactivity Info 
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CP0346103
 Compound Info 
5-methyl-2-(4-methylbenzoyl)-1H-pyrazol-3-one
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C12H12N2O2
  1
1
IC50 = 10100 nM
 Bioactivity Info 
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CP0213064
 Compound Info 
4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl-1H-pyrazole
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C12H10Cl2N2O
  1
1
IC50 = 22360 nM
 Bioactivity Info 
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CP0249219
 Compound Info 
(4-chlorophenyl)-(3,5-dimethylpyrazol-1-yl)methanone
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C12H11ClN2O
  1
1
IC50 = 36130 nM
 Bioactivity Info 
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CP0386814
 Compound Info 
(4-chloro-3,5-dimethylpyrazol-1-yl)-(4-methylphenyl)methanone
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C13H13ClN2O
  1
1
IC50 = 36540 nM
 Bioactivity Info 
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CP0068517
 Compound Info 
(4-aminophenyl)-(3,5-dimethylpyrazol-1-yl)methanone
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C12H13N3O
  1
1
IC50 = 37230 nM
 Bioactivity Info 
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CP0360393
 Compound Info 
(E)-1-(4-chloro-3,5-dimethylpyrazol-1-yl)-3-phenylprop-2-en-1-one
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C14H13ClN2O
  1
1
IC50 = 38510 nM
 Bioactivity Info 
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CP0080092
 Compound Info 
(3,5-dimethylpyrazol-1-yl)-(3-methylphenyl)methanone
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C13H14N2O
  1
1
IC50 = 41530 nM
 Bioactivity Info 
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CP0068518
 Compound Info 
(4-chloro-3,5-dimethylpyrazol-1-yl)-naphthalen-2-ylmethanone
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C16H13ClN2O
  1
1
IC50 = 44000 nM
 Bioactivity Info 
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CP0360392
 Compound Info 
(4-chloro-3,5-dimethylpyrazol-1-yl)-pyridin-4-ylmethanone
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C11H10ClN3O
  1
1
IC50 = 44200 nM
 Bioactivity Info 
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CP0197995
 Compound Info 
(3,5-dimethylpyrazol-1-yl)-naphthalen-2-ylmethanone
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C16H14N2O
  1
1
IC50 = 44510 nM
 Bioactivity Info 
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CP0360394
 Compound Info 
(4-aminophenyl)-[3,5-dimethyl-4-(4-methylphenoxy)pyrazol-1-yl]methanone
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C19H19N3O2
  1
1
IC50 = 44680 nM
 Bioactivity Info 
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CP0386818
 Compound Info 
(3,5-Dimethyl-pyrazol-1-yl)-pyridin-4-yl-methanone
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C11H11N3O
  1
1
IC50 = 47580 nM
 Bioactivity Info 
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CP0248022
 Compound Info 
(4-aminophenyl)-(4-chloro-3,5-dimethylpyrazol-1-yl)methanone
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C12H12ClN3O
  1
1
IC50 = 48220 nM
 Bioactivity Info 
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CP0080094
 Compound Info 
2-(4-aminobenzoyl)-5-methyl-1H-pyrazol-3-one
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C11H11N3O2
  1
1
IC50 = 48950 nM
 Bioactivity Info 
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CP0393057
 Compound Info 
(4-chlorophenyl)-[3,5-dimethyl-4-(4-methylphenoxy)pyrazol-1-yl]methanone
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C19H17ClN2O2
  1
1
IC50 = 58690 nM
 Bioactivity Info 
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Biochemical Assays
Compound ID Compound Name Compound Formula
CP0652101
 Compound Info 
Reactive Blue-2
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C29H17ClN7Na3O11S3
  1
1 Ki = 20000 nM
CP0786724
 Compound Info 
ARL-67156
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C15H20Br2N5Na4O12P3
  1
1 Ki = 27000 nM