General Information of the Protein
Protein ID
PT02883
Protein Name
Superoxide dismutase [Cu-Zn]
Secondarily
Protein Name
Superoxide dismutase 1
Gene Name
SOD1
Sequence
MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
Function
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
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Uniprot ID
Primary ID:
P00441

Secondarily ID:
A6NHJ0
D3DSE4
Q16669
Q16711
Q16838
Q16839
Q16840
Q6NR85
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Ensembl ID
ENSG00000142168
HGNC ID
HGNC:11179
Subcellular Location
Cytoplasm
Mitochondrion
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000868 , PC12
Compound ID Compound Name Compound Formula
CP0048134
5-[(3,5-dichlorophenoxy)methyl]-1,2-dihydropyrazol-3-one
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C10H8Cl2N2O2
 1
1
EC50 = 67 nM
   TI
   LI
   LO
   TS
CP0906856
5-((3,5-Dichlorophenylthio)methyl)-1H-pyrazol-3(2H)-one
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C10H8Cl2N2OS
 1
1
EC50 = 170 nM
   TI
   LI
   LO
   TS
CP0883026
5-((3,5-Dibromophenoxy)methyl)-1H-pyrazol-3(2H)-one
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C10H8Br2N2O2
 1
1
EC50 = 510 nM
   TI
   LI
   LO
   TS
CP0915182
5-((3,5-Bis(trifluoromethyl)phenoxy)methyl)-1H-pyrazol-3(2H)-one
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C12H8F6N2O2
 1
1
EC50 = 580 nM
   TI
   LI
   LO
   TS
CP0889415
5-((2,6-Dichlorophenylthio)methyl)-1H-pyrazol-3(2H)-one
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C10H8Cl2N2OS
 1
1
EC50 = 710 nM
   TI
   LI
   LO
   TS
CP0911335
5-((3-Ethylphenoxy)methyl)-1H-pyrazol-3(2H)-one
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C12H14N2O2
 1
1
EC50 = 720 nM
   TI
   LI
   LO
   TS
CP0924959
5-((4-Chlorophenoxy)methyl)-1H-pyrazol-3(2H)-one
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C10H9ClN2O2
 1
1
EC50 = 790 nM
   TI
   LI
   LO
   TS
CP0847419
5-((3-tert-Butylphenoxy)methyl)-1H-pyrazol-3(2H)-one
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C14H18N2O2
 1
1
EC50 = 870 nM
   TI
   LI
   LO
   TS
CP0882911
5-((3-Bromophenoxy)methyl)-1H-pyrazol-3(2H)-one
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C10H9BrN2O2
 1
1
EC50 = 1020 nM
   TI
   LI
   LO
   TS
CP0915181
5-((3,5-Difluorophenoxy)methyl)-1H-pyrazol-3(2H)-one
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C10H8F2N2O2
 1
1
EC50 = 1070 nM
   TI
   LI
   LO
   TS
CP0891959
5-((3,5-dichlorophenylsulfonyl)methyl)-1H-pyrazol-3(2H)-one
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C10H8Cl2N2O3S
 1
1
EC50 = 1410 nM
   TI
   LI
   LO
   TS
CP0847420
5-((4-chloro-2,5-dimethylphenylsulfonyl)methyl)-1H-pyrazol-3(2H)-one
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C12H13ClN2O3S
 1
1
EC50 = 1470 nM
   TI
   LI
   LO
   TS
CP0924108
5-((4-Chlorophenylthio)methyl)-1H-pyrazol-3(2H)-one
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C10H9ClN2OS
 1
1
EC50 = 1930 nM
   TI
   LI
   LO
   TS
CP0875424
5-((4-Ethylphenoxy)methyl)-1H-pyrazol-3(2H)-one
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C12H14N2O2
 1
1
EC50 = 1960 nM
   TI
   LI
   LO
   TS
CP0917588
5-((Biphenyl-3-yloxy)methyl)-1H-pyrazol-3(2H)-one
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C16H14N2O2
 1
1
EC50 = 2840 nM
   TI
   LI
   LO
   TS
CP0906857
5-((4-chloro-2,5-dimethylphenylsulfinyl)methyl)-1H-pyrazol-3(2H)-one
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C12H13ClN2O2S
 1
1
EC50 = 2880 nM
   TI
   LI
   LO
   TS
CP0924960
5-((5-Phenylbiphenyl-3-yloxy)methyl)-1H-pyrazol-3(2H)-one
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C22H18N2O2
 1
1
EC50 = 3700 nM
   TI
   LI
   LO
   TS
CP0911336
5-((4-chlorophenylsulfonyl)methyl)-1H-pyrazol-3(2H)-one
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C10H9ClN2O3S
 1
1
EC50 = 4700 nM
   TI
   LI
   LO
   TS
CP0944603
5-((4-chlorophenylsulfinyl)methyl)-1H-pyrazol-3(2H)-one
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C10H9ClN2O2S
 1
1
EC50 > 32000 nM
   TI
   LI
   LO
   TS
Clinical Information about the Protein
Target 1 ( Superoxide dismutase Cu-Zn (SOD Cu-Zn) )
Target Type Clinical trial Target
Disease 1 Target-related Disease  1
1 Spinal cord injury [ICD-11: ND51.2]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 Tempol Phase 2
Spinal cord injury
Target 2 ( SOD1 messenger RNA (SOD1 mRNA) )
Target Type Successful Target