General Information of the Protein
Protein ID
PT02836
Protein Name
Voltage-dependent N-type calcium channel subunit alpha-1B
Secondarily
Protein Name
Brain calcium channel III
Calcium channel
L type
alpha-1 polypeptide isoform 5
Voltage-gated calcium channel subunit alpha Cav2.2
Gene Name
CACNA1B
Secondarily
Gene Name
Cach5
Cacnl1a5
Sequence
MVRFGDELGGRYGGTGGGERARGGGAGGAGGPGQGGLPPGQRVLYKQSIAQRARTMALYNPIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTEILATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAPARLCDSDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDAVLKRAATKKSRNDLIHAEEGEDRFVDLCAAGSPFARASLKSGKTESSSYFRRKEKMFRFLIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPQRLTTALYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSIFEVVWAAIKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRYASTRHVRPDMKTHMDRPLVVEPGRDGLRGPAGNKSKPEGTEATEGADPPRRHHRHRDRDKTSASTPAGGEQDRTDCPKAESTETGAREERARPRRSHSKEAPGADTQVRCERSRRHHRRGSPEEATEREPRRHRAHRHAQDSSKEGKEGTAPVLVPKGERRARHRGPRTGPRETENSEEPTRRHRAKHKVPPTLEPPEREVAEKESNVVEGDKETRNHQPKEPRCDLEAIAVTGVGSLHMLPSTCLQKVDEQPEDADNQRNVTRMGSQPSDPSTTVHVPVTLTGPPGEATVVPSANTDLEGQAEGKKEAEADDVLRRGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEMVILVVIALSSIALAAEDPVRTDSFRNNALKYMDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSSFMGGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNKQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSLECILKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIANNFINLSFLRLFRAARLIKLCRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDGTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLGNRACDPHANASECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELRKEISSVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQTHQAPGGLSQMGPVSLFHPLKATLEQTQPAVLRGARVFLRQKSATSLSNGGAIQTQESGIKESLSWGTQRTQDVLYEARAPLERGHSAEIPVGQPGALAVDVQMQNMTLRGPDGEPQPGLESQGRAASMPRLAAETQPAPNASPMKRSISTLAPRPHGTQLCNTVLDRPPPSQVSHHHHHRCHRRRDKKQRSLEKGPSLSVDTEGAPSTAAGSGLPHGEGSTGCRRERKQERGRSQERRQPSSSSSEKQRFYSCDRFGSREPPQPKPSLSSHPISPTAALEPGPHPQGSGSVNGSPLMSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANSSPVHFAEGQSGLPAFSPGRLSRGLSEHNALLQKEPLSQPLASGSRIGSDPYLGQRLDSEASAHNLPEDTLTFEEAVATNSGRSSRTSYVSSLTSQSHPLRRVPNGYHCTLGLSTGVRARHSYHHPDQDHWC
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Organism
Rattus norvegicus, Rat
Protein Classification
Ion channel
>
Voltage-gated ion channel
>
Voltage-gated calcium channel
Function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Mediates Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (PubMed:23699505).
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Uniprot ID
Q02294
Ensembl ID
ENSG00000148408
Subcellular Location
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
Compound ID Compound Name Compound Formula
CP0000317
3,3-diphenyl-1-[4-[phenyl-[4-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]propan-1-one
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C33H31F3N2O
 2
1
IC50 = 74 nM
   TI
   LI
   LO
   TS
2
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0009552
3,3-diphenyl-1-[4-[phenyl-[3-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]propan-1-one
   Show/Hide
C33H31F3N2O
 2
1
IC50 = 105 nM
   TI
   LI
   LO
   TS
2
IC50 = 200 nM
   TI
   LI
   LO
   TS
CP0634380
1-{4-[(4-Methoxy-phenyl)-(4-trifluoromethyl-phenyl)-methyl]-piperazin-1-yl}-3,3-diphenyl-propan-1-one
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C34H33F3N2O2
 2
1
IC50 = 111 nM
   TI
   LI
   LO
   TS
2
IC50 = 291 nM
   TI
   LI
   LO
   TS
CP0634378
1-{4-[(3,5-Ditert-butyl-4-hydroxyphenyl)-phenyl-methyl]-piperazin-1-yl}-3,3-diphenyl-propan-1-one
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C40H48N2O2
 2
1
IC50 = 114 nM
   TI
   LI
   LO
   TS
2
IC50 = 213 nM
   TI
   LI
   LO
   TS
CP0009367
1-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]-3,3-diphenylpropan-1-one
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C32H31ClN2O
 2
1
IC50 = 120 nM
   TI
   LI
   LO
   TS
2
IC50 = 170 nM
   TI
   LI
   LO
   TS
CP0634379
4-Benzhydryl-1-(3,3-diphenyl-propionyl)-piperazine-2-carboxylic acid ethyl ester
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C35H36N2O3
 2
1
IC50 = 120 nM
   TI
   LI
   LO
   TS
2
IC50 = 160 nM
   TI
   LI
   LO
   TS
CP0888289
1-[4-(Benzo[1,3]dioxol-5-yl-phenyl-methyl)-piperazin-1-yl]-3,3-diphenyl-propan-1-one
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C33H32N2O3
 2
1
IC50 = 137 nM
   TI
   LI
   LO
   TS
2
IC50 = 213 nM
   TI
   LI
   LO
   TS
CP0848371
4-Benzhydryl-1-(3,3-diphenylpropionyl)-piperazine-2-carboxylic acid
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C33H32N2O3
 2
1
IC50 = 140 nM
   TI
   LI
   LO
   TS
2
IC50 = 230 nM
   TI
   LI
   LO
   TS
CP0001395
1-[4-[(3,5-dichlorophenyl)-phenylmethyl]piperazin-1-yl]-3,3-diphenylpropan-1-one
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C32H30Cl2N2O
 2
1
IC50 = 170 nM
   TI
   LI
   LO
   TS
2
IC50 = 230 nM
   TI
   LI
   LO
   TS
CP0888290
1-{4-[(4-tert-Butyl-phenyl)-phenyl-methyl]-piperazin-1-yl}-3,3-diphenyl-propan-1-one
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C36H40N2O
 2
1
IC50 = 190 nM
   TI
   LI
   LO
   TS
2
IC50 = 370 nM
   TI
   LI
   LO
   TS
CP0901823
1-{4-[(3,5-Bis-trifluoromethyl-phenyl)-phenyl-methyl]-piperazin-1-yl}-3,3-diphenyl-propan-1-one hydrochloride
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C34H31ClF6N2O
 2
1
IC50 = 190 nM
   TI
   LI
   LO
   TS
2
IC50 = 300 nM
   TI
   LI
   LO
   TS
CP0902776
1-{4-[(2-Difluoromethoxy-phenyl)-phenyl-methyl]-piperazin-1-yl}-3,3-diphenyl-propan-1-one
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C33H32F2N2O2
 2
1
IC50 = 190 nM
   TI
   LI
   LO
   TS
2
IC50 = 340 nM
   TI
   LI
   LO
   TS
CP0005546
1-[4-[(3,5-dimethoxyphenyl)-phenylmethyl]piperazin-1-yl]-3,3-diphenylpropan-1-one
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C34H36N2O3
 2
1
IC50 = 210 nM
   TI
   LI
   LO
   TS
2
IC50 = 320 nM
   TI
   LI
   LO
   TS
CP0863073
1-{4-[(2,6-Dichloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-3,3-diphenyl-propan-1-one hydrochloride
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C32H31Cl3N2O
 2
1
IC50 = 210 nM
   TI
   LI
   LO
   TS
2
IC50 = 300 nM
   TI
   LI
   LO
   TS
CP0009666
1-[4-[(2,3-dichlorophenyl)-phenylmethyl]piperazin-1-yl]-3,3-diphenylpropan-1-one
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C32H30Cl2N2O
 2
1
IC50 = 217 nM
   TI
   LI
   LO
   TS
2
IC50 = 348 nM
   TI
   LI
   LO
   TS
CP0932943
3,3-Diphenyl-1-[4-(9H-xanthen-9-yl)-piperazin-1-yl]-propan-1-one
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C32H30N2O2
 2
1
IC50 = 220 nM
   TI
   LI
   LO
   TS
2
IC50 = 290 nM
   TI
   LI
   LO
   TS
CP0848372
1-{4-[(4-Benzyloxy-phenyl)-phenyl-methyl]-piperazin-1-yl}-3,3-diphenyl-propan-1-one
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C39H38N2O2
 2
1
IC50 = 233 nM
   TI
   LI
   LO
   TS
2
IC50 = 286 nM
   TI
   LI
   LO
   TS
CP0008576
1-[4-[(2,4-dimethylphenyl)-phenylmethyl]piperazin-1-yl]-3,3-diphenylpropan-1-one
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C34H36N2O
 2
1
IC50 = 237 nM
   TI
   LI
   LO
   TS
2
IC50 = 324 nM
   TI
   LI
   LO
   TS
CP0000413
1-[4-[bis(4-methoxyphenyl)methyl]piperazin-1-yl]-3,3-diphenylpropan-1-one
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C34H36N2O3
 2
1
IC50 = 249 nM
   TI
   LI
   LO
   TS
2
IC50 = 360 nM
   TI
   LI
   LO
   TS
CP0001558
1-[4-[(4-methoxyphenyl)-phenylmethyl]piperazin-1-yl]-3,3-diphenylpropan-1-one
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C33H34N2O2
 2
1
IC50 = 250 nM
   TI
   LI
   LO
   TS
2
IC50 = 320 nM
   TI
   LI
   LO
   TS
CP0921849
1-{4-[(4-Hydroxy-3,5-dimethoxy-phenyl)-phenyl-methyl]-piperazin-1-yl}-3,3-diphenyl-propan-1-one
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C34H36N2O4
 2
1
IC50 = 252 nM
   TI
   LI
   LO
   TS
2
IC50 = 437 nM
   TI
   LI
   LO
   TS
CP0009368
3,3-diphenyl-1-[4-[phenyl-[2-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]propan-1-one
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C33H31F3N2O
 2
1
IC50 = 301 nM
   TI
   LI
   LO
   TS
2
IC50 = 538 nM
   TI
   LI
   LO
   TS
CP0008583
1-[4-[(4-methylphenyl)-phenylmethyl]piperazin-1-yl]-3,3-diphenylpropan-1-one
   Show/Hide
C33H34N2O
 2
1
IC50 = 310 nM
   TI
   LI
   LO
   TS
2
IC50 = 490 nM
   TI
   LI
   LO
   TS
CP0001396
1-[4-[(4-fluorophenyl)-phenylmethyl]piperazin-1-yl]-3,3-diphenylpropan-1-one
   Show/Hide
C32H31FN2O
 2
1
IC50 = 380 nM
   TI
   LI
   LO
   TS
2
IC50 = 600 nM
   TI
   LI
   LO
   TS
CP0942270
1-{4-[(3,5-Bis-trifluoromethyl-phenyl)-phenyl-methyl]-piperazin-1-yl}-3,3-diphenyl-propan-1-one
   Show/Hide
C34H30F6N2O
 2
1
IC50 = 450 nM
   TI
   LI
   LO
   TS
2
IC50 = 550 nM
   TI
   LI
   LO
   TS
CP0008582
3,3-diphenyl-1-[4-[phenyl-(3,4,5-trimethoxyphenyl)methyl]piperazin-1-yl]propan-1-one
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C35H38N2O4
 2
1
IC50 = 513 nM
   TI
   LI
   LO
   TS
2
IC50 = 1090 nM
   TI
   LI
   LO
   TS
CP0895941
1-{4-[Benzo[1,3]dioxol-5-yl-(4-methoxy-phenyl)-methyl]-piperazin-1-yl}-3,3-diphenyl-propan-1-one
   Show/Hide
C34H34N2O4
 2
1
IC50 = 533 nM
   TI
   LI
   LO
   TS
2
IC50 = 710 nM
   TI
   LI
   LO
   TS
CP0851270
1-[4-(10,10-Dioxo-9,10-dihydro-10lambda6-thioxanthen-9-yl)-piperazin-1-yl]-3,3-diphenyl-propan-1-one
   Show/Hide
C32H30N2O3S
 2
1
IC50 = 552 nM
   TI
   LI
   LO
   TS
2
IC50 = 854 nM
   TI
   LI
   LO
   TS
CP0851272
1-Benzhydryl-4-(3,3-diphenylpropionyl)-piperazin-2-one
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C32H30N2O2
 2
1
IC50 = 680 nM
   TI
   LI
   LO
   TS
2
IC50 = 737 nM
   TI
   LI
   LO
   TS
CP0888452
1-[4-(10,11-Dihydro-5Hdibenzo[a,d]cyclohepten-5-yl)-piperazin-1-yl]-3,3-diphenylpropan-1-one hydrochloride
   Show/Hide
C34H35ClN2O
 2
1
IC50 = 830 nM
   TI
   LI
   LO
   TS
2
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0524037
4-[(2R,5R)-1-benzhydryl-5-methylpiperazin-2-yl]butan-1-ol
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C22H30N2O
 1
1
IC50 = 850 nM
   TI
   LI
   LO
   TS
CP0477799
4-[(2R,5R)-1-benzhydryl-5-methylpiperazin-2-yl]butoxy-tert-butyl-dimethylsilane
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C28H44N2OSi
 1
1
IC50 = 1070 nM
   TI
   LI
   LO
   TS
CP0433688
(2R,5R)-1-benzhydryl-5-methyl-2-pentylpiperazine
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C23H32N2
 1
1
IC50 = 2400 nM
   TI
   LI
   LO
   TS
CP0375435
3-[(2R,5R)-1-benzhydryl-5-methyl-4-(4-methylphenyl)sulfonylpiperazin-2-yl]propoxy-tert-butyl-dimethylsilane
   Show/Hide
C34H48N2O3SSi
 1
1
IC50 = 2600 nM
   TI
   LI
   LO
   TS
CP0380989
(2R,5R)-1-benzhydryl-2-benzyl-5-methylpiperazine
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C25H28N2
 1
1
IC50 = 4340 nM
   TI
   LI
   LO
   TS
CP0477795
4-[(2R,5R)-1-benzhydryl-5-methyl-4-(4-methylphenyl)sulfonylpiperazin-2-yl]butoxy-tert-butyl-dimethylsilane
   Show/Hide
C35H50N2O3SSi
 1
1
IC50 = 4700 nM
   TI
   LI
   LO
   TS
CP0477797
4-[(2R,5R)-1-benzyl-5-methylpiperazin-2-yl]butoxy-tert-butyl-dimethylsilane
   Show/Hide
C22H40N2OSi
 1
1
IC50 = 4850 nM
   TI
   LI
   LO
   TS
CP0489343
(2R,5R)-2-benzyl-1-[(4-fluorophenyl)methyl]-5-methylpiperazine
   Show/Hide
C19H23FN2
 1
1
IC50 = 8370 nM
   TI
   LI
   LO
   TS
CP0381638
4-[(2R,5R)-1-benzyl-5-methylpiperazin-2-yl]butan-1-ol
   Show/Hide
C16H26N2O
 1
1
IC50 = 9600 nM
   TI
   LI
   LO
   TS
CP0536152
(2R,5R)-1-benzyl-5-methyl-2-pentylpiperazine
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C17H28N2
 1
1
IC50 = 9840 nM
   TI
   LI
   LO
   TS
CP0380987
(2R,5R)-1,2-dibenzyl-5-methylpiperazine
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C19H24N2
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0380988
3-[(2R,5R)-1-benzhydryl-5-methylpiperazin-2-yl]propoxy-tert-butyl-dimethylsilane
   Show/Hide
C27H42N2OSi
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0433690
(2R,5R)-2-benzyl-1-[(4-fluorophenyl)methyl]-5-methyl-4-[4-(trifluoromethyl)phenyl]sulfonylpiperazine
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C26H26F4N2O2S
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0524036
1-[(2R,5R)-5-benzyl-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2,2-diphenylethanone
   Show/Hide
C33H33FN2O
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0536151
4-[(2R,5R)-1-benzhydryl-5-methyl-4-[4-(trifluoromethyl)phenyl]sulfonylpiperazin-2-yl]butoxy-tert-butyl-dimethylsilane
   Show/Hide
C35H47F3N2O3SSi
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0537920
(2R,5R)-1-benzyl-5-methyl-2-nonylpiperazine
   Show/Hide
C21H36N2
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0559125
(2R,5R)-1,2-dibenzyl-5-methyl-4-[4-(trifluoromethyl)phenyl]sulfonylpiperazine
   Show/Hide
C26H27F3N2O2S
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0008581
1-[4-[(2,4-dichlorophenyl)-phenylmethyl]piperazin-1-yl]-3,3-diphenylpropan-1-one
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C32H30Cl2N2O
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0005547
1-[4-[(3,4-dichlorophenyl)-phenylmethyl]piperazin-1-yl]-3,3-diphenylpropan-1-one
   Show/Hide
C32H30Cl2N2O
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0895942
1-{4-[(2,4-Dichloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-3,3-diphenyl-propan-1-one hydrochloride
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C32H31Cl3N2O
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT02031 Voltage-dependent N-type calcium channel subunit alpha-1B Homo sapiens, Human