General Information of the Compound
Compound ID
CP0851270
Compound Name
1-[4-(10,10-Dioxo-9,10-dihydro-10lambda6-thioxanthen-9-yl)-piperazin-1-yl]-3,3-diphenyl-propan-1-one
    Show/Hide
Structure
Formula
C32H30N2O3S
Molecular Weight
522.67
Canonical SMILES
O=C(CC(c1ccccc1)c1ccccc1)N1CCN(C2c3ccccc3S(=O)(=O)c3ccccc32)CC1
    Show/Hide
InChI
InChI=1S/C32H30N2O3S/c35-31(23-28(24-11-3-1-4-12-24)25-13-5-2-6-14-25)33-19-21-34(22-20-33)32-26-15-7-9-17-29(26)38(36,37)30-18-10-8-16-27(30)32/h1-18,28,32H,19-23H2
    Show/Hide
InChIKey
ORPWYENZTHYPMM-UHFFFAOYSA-N
Physicochemical Property
logP
5.2886
Rotatable Bonds
5
Heavy Atom Count
38
Polar Areas
57.69
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 10482902
ChEMBL ID
CHEMBL3956949
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02836, Voltage-dependent N-type calcium channel subunit alpha-1B
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 552 nM
   TI
   LI
   LO
   TS
2
IC50 = 854 nM
   TI
   LI
   LO
   TS