General Information of the Protein
Protein ID
PT02825
Protein Name
Fatty acid synthase
Secondarily
Protein Name
Type I fatty acid synthase
Gene Name
FASN
Secondarily
Gene Name
FAS
Sequence
MEEVVIAGMSGKLPESENLQEFWDNLIGGVDMVTDDDRRWKAGLYGLPRRSGKLKDLSRFDASFFGVHPKQAHTMDPQLRLLLEVTYEAIVDGGINPDSLRGTHTGVWVGVSGSETSEALSRDPETLVGYSMVGCQRAMMANRLSFFFDFRGPSIALDTACSSSLMALQNAYQAIHSGQCPAAIVGGINVLLKPNTSVQFLRLGMLSPEGTCKAFDTAGNGYCRSEGVVAVLLTKKSLARRVYATILNAGTNTDGFKEQGVTFPSGDIQEQLIRSLYQSAGVAPESFEYIEAHGTGTKVGDPQELNGITRALCATRQEPLLIGSTKSNMGHPEPASGLAALAKVLLSLEHGLWAPNLHFHSPNPEIPALLDGRLQVVDQPLPVRGGNVGINSFGFGGSNVHIILRPNTQPPPAPAPHATLPRLLRASGRTPEAVQKLLEQGLRHSQDLAFLSMLNDIAAVPATAMPFRGYAVLGGERGGPEVQQVPAGERPLWFICSGMGTQWRGMGLSLMRLDRFRDSILRSDEAVKPFGLKVSQLLLSTDESTFDDIVHSFVSLTAIQIGLIDLLSCMGLRPDGIVGHSLGEVACGYADGCLSQEEAVLAAYWRGQCIKEAHLPPGAMAAVGLSWEECKQRCPPGVVPACHNSKDTVTISGPQAPVFEFVEQLRKEGVFAKEVRTGGMAFHSYFMEAIAPPLLQELKKVIREPKPRSARWLSTSIPEAQWHSSLARTSSAEYNVNNLVSPVLFQEALWHVPEHAVVLEIAPHALLQAVLKRGLKPSCTIIPLMKKDHRDNLEFFLAGIGRLHLSGIDANPNALFPPVEFPAPRGTPLISPLIKWDHSLAWDVPAAEDFPNGSGSPSAAIYNIDTSSESPDHYLVDHTLDGRVLFPATGYLSIVWKTLARALGLGVEQLPVVFEDVVLHQATILPKTGTVSLEVRLLEASRAFEVSENGNLVVSGKVYQWDDPDPRLFDHPESPTPNPTEPLFLAQAEVYKELRLRGYDYGPHFQGILEASLEGDSGRLLWKDNWVSFMDTMLQMSILGSAKHGLYLPTRVTAIHIDPATHRQKLYTLQDKAQVADVVVSRWLRVTVAGGVHISGLHTESAPRRQQEQQVPILEKFCFTPHTEEGCLSERAALQEELQLCKGLVQALQTKVTQQGLKMVVPGLDGAQIPRDPSQQELPRLLSAACRLQLNGNLQLELAQVLAQERPKLPEDPLLSGLLDSPALKACLDTAVENMPSLKMKVVEVLAGHGHLYSRIPGLLSPHPLLQLSYTATDRHPQALEAAQAELQQHDVAQGQWDPADPAPSALGSADLLVCNCAVAALGDPASALSNMVAALREGGFLLLHTLLRGHPLGDIVAFLTSTEPQYGQGILSQDAWESLFSRVSLRLVGLKKSFYGSTLFLCRRPTPQDSPIFLPVDDTSFRWVESLKGILADEDSSRPVWLKAINCATSGVVGLVNCLRREPGGNRLRCVLLSNLSSTSHVPEVDPGSAELQKVLQGDLVMNVYRDGAWGAFRHFLLEEDKPEEPTAHAFVSTLTRGDLSSIRWVCSSLRHAQPTCPGAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWTSQDSLLGMEFSGRDASGKRVMGLVPAKGLATSVLLSPDFLWDVPSNWTLEEAASVPVVYSTAYYALVVRGRVRPGETLLIHSGSGGVGQAAIAIALSLGCRVFTTVGSAEKRAYLQARFPQLDSTSFANSRDTSFEQHVLWHTGGKGVDLVLNSLAEEKLQASVRCLATHGRFLEIGKFDLSQNHPLGMAIFLKNVTFHGVLLDAFFNESSADWREVWALVQAGIRDGVVRPLKCTVFHGAQVEDAFRYMAQGKHIGKVVVQVLAEEPEAVLKGAKPKLMSAISKTFCPAHKSYIIAGGLGGFGLELAQWLIQRGVQKLVLTSRSGIRTGYQAKQVRRWRRQGVQVQVSTSNISSLEGARGLIAEAAQLGPVGGVFNLAVVLRDGLLENQTPEFFQDVCKPKYSGTLNLDRVTREACPELDYFVVFSSVSCGRGNAGQSNYGFANSAMERICEKRRHEGLPGLAVQWGAIGDVGILVETMSTNDTIVSGTLPQRMASCLEVLDLFLNQPHMVLSSFVLAEKAAAYRDRDSQRDLVEAVAHILGIRDLAAVNLDSSLADLGLDSLMSVEVRQTLERELNLVLSVREVRQLTLRKLQELSSKADEASELACPTPKEDGLAQQQTQLNLRSLLVNPEGPTLMRLNSVQSSERPLFLVHPIEGSTTVFHSLASRLSIPTYGLQCTRAAPLDSIHSLAAYYIDCIRQVQPEGPYRVAGYSYGACVAFEMCSQLQAQQSPAPTHNSLFLFDGSPTYVLAYTQSYRAKLTPGCEAEAETEAICFFVQQFTDMEHNRVLEALLPLKGLEERVAAAVDLIIKSHQGLDRQELSFAARSFYYKLRAAEQYTPKAKYHGNVMLLRAKTGGAYGEDLGADYNLSQVCDGKVSVHVIEGDHRTLLEGSGLESIISIIHSSLAEPRVSVREG
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Transferase
Function
Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.
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Uniprot ID
Primary ID:
P49327

Secondarily ID:
Q13479
Q16702
Q4LE83
Q6P4U5
Q6SS02
Q969R1
Q96C68
Q96IT0
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Ensembl ID
ENSG00000169710
HGNC ID
HGNC:3594
Subcellular Location
Cytoplasm
Melanosome
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000218 , BT-474
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0488048
 Compound Info 
[4-(1,3-benzothiazol-5-yl)phenyl]-[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]methanone
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C22H21N3O3S
  1
1
IC50 = 11 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0562430
 Compound Info 
[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]-(4-isoquinolin-6-ylphenyl)methanone
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C24H23N3O3
  1
1
IC50 = 11 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0473255
 Compound Info 
[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]-(4-quinolin-3-ylphenyl)methanone
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C24H23N3O3
  1
1
IC50 = 12 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0259298
 Compound Info 
[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]-[4-(1H-indol-5-yl)phenyl]methanone
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C23H23N3O3
  1
1
IC50 = 18 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0144081
 Compound Info 
[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]-[4-(1-methylindol-5-yl)phenyl]methanone
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C24H25N3O3
  1
1
IC50 = 19 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0562431
 Compound Info 
[4-(5-fluoro-1,3-benzoxazol-2-yl)phenyl]-[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]methanone
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C22H20FN3O4
  1
1
IC50 = 61 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0553990
 Compound Info 
[4-(1,3-benzothiazol-2-yl)phenyl]-[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]methanone
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C22H21N3O3S
  1
1
IC50 = 67 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0421512
 Compound Info 
[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]-[4-(1-methylindol-2-yl)phenyl]methanone
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C24H25N3O3
  1
1
IC50 = 70 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0564374
 Compound Info 
[4-(6-fluoro-1,3-benzoxazol-2-yl)phenyl]-[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]methanone
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C22H20FN3O4
  1
1
IC50 = 90 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0349048
 Compound Info 
[4-(1,3-benzoxazol-2-yl)phenyl]-[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]methanone
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C22H21N3O4
  1
1
IC50 = 101 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0564373
 Compound Info 
[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]-(4-quinolin-2-ylphenyl)methanone
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C24H23N3O3
  1
1
IC50 = 101 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0564178
 Compound Info 
[4-(6-chloro-1,3-benzoxazol-2-yl)phenyl]-[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]methanone
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C22H20ClN3O4
  1
1
IC50 = 104 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0567582
 Compound Info 
[4-(5-chloro-1,3-benzoxazol-2-yl)phenyl]-[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]methanone
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C22H20ClN3O4
  1
1
IC50 = 136 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0574661
 Compound Info 
[4-(5-chloro-2-fluorophenyl)phenyl]-[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]methanone
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C21H20ClFN2O3
  1
1
IC50 = 158 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0144080
 Compound Info 
[4-(1,3-benzoxazol-5-yl)phenyl]-[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]methanone
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C22H21N3O4
  1
1
IC50 = 257 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0349049
 Compound Info 
[4-(4-chloro-2-fluorophenyl)phenyl]-[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]methanone
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C21H20ClFN2O3
  1
1
IC50 = 336 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0543768
 Compound Info 
[4-(2-chloro-4-fluorophenyl)phenyl]-[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]methanone
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C21H20ClFN2O3
  1
1
IC50 = 4960 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000017 , HeLa
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0473255
 Compound Info 
[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]-(4-quinolin-3-ylphenyl)methanone
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C24H23N3O3
  1
1 IC50 = 10 nM
CP0144081
 Compound Info 
[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]-[4-(1-methylindol-5-yl)phenyl]methanone
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C24H25N3O3
  1
1 IC50 = 12 nM
CP0562430
 Compound Info 
[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]-(4-isoquinolin-6-ylphenyl)methanone
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C24H23N3O3
  1
1 IC50 = 13 nM
CP0259298
 Compound Info 
[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]-[4-(1H-indol-5-yl)phenyl]methanone
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C23H23N3O3
  1
1 IC50 = 16 nM
CP0303879
 Compound Info 
4-[1-[2,4-dimethyl-5-(6-pyrrolidin-1-yl-3H-imidazo[4,5-c]pyridin-2-yl)benzoyl]piperidin-4-yl]benzonitrile
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C31H32N6O
  1
1 IC50 = 17 nM
CP0488048
 Compound Info 
[4-(1,3-benzothiazol-5-yl)phenyl]-[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]methanone
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C22H21N3O3S
  1
1 IC50 = 32 nM
CP0564373
 Compound Info 
[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]-(4-quinolin-2-ylphenyl)methanone
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C24H23N3O3
  1
1 IC50 = 32 nM
CP0421512
 Compound Info 
[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]-[4-(1-methylindol-2-yl)phenyl]methanone
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C24H25N3O3
  1
1 IC50 = 33 nM
CP0349048
 Compound Info 
[4-(1,3-benzoxazol-2-yl)phenyl]-[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]methanone
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C22H21N3O4
  1
1 IC50 = 54 nM
CP0553990
 Compound Info 
[4-(1,3-benzothiazol-2-yl)phenyl]-[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]methanone
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C22H21N3O3S
  1
1 IC50 = 57 nM
CP0567582
 Compound Info 
[4-(5-chloro-1,3-benzoxazol-2-yl)phenyl]-[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]methanone
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C22H20ClN3O4
  1
1 IC50 = 69 nM
CP0031823
 Compound Info 
(1R,3S)-N-[4-(1,3-benzoxazol-2-yl)phenyl]-N-methyl-3-(propanoylamino)cyclopentane-1-carboxamide
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C23H25N3O3
  2
1 IC50 = 79 nM
2 IC50 ~ 79 nM
CP0564178
 Compound Info 
[4-(6-chloro-1,3-benzoxazol-2-yl)phenyl]-[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]methanone
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C22H20ClN3O4
  1
1 IC50 = 97 nM
CP0349049
 Compound Info 
[4-(4-chloro-2-fluorophenyl)phenyl]-[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]methanone
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C21H20ClFN2O3
  1
1 IC50 = 110 nM
CP0574661
 Compound Info 
[4-(5-chloro-2-fluorophenyl)phenyl]-[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]methanone
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C21H20ClFN2O3
  1
1 IC50 = 110 nM
CP0144080
 Compound Info 
[4-(1,3-benzoxazol-5-yl)phenyl]-[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]methanone
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C22H21N3O4
  1
1 IC50 = 142 nM
CP0140882
 Compound Info 
(1R,3S)-N-[4-(1H-benzimidazol-2-yl)phenyl]-N-methyl-3-(propanoylamino)cyclopentane-1-carboxamide
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C23H26N4O2
  1
1 IC50 = 190 nM
CP0562431
 Compound Info 
[4-(5-fluoro-1,3-benzoxazol-2-yl)phenyl]-[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]methanone
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C22H20FN3O4
  1
1 IC50 = 192 nM
CP0313633
 Compound Info 
(1R,3S)-3-acetamido-N-[4-(1,3-benzoxazol-2-yl)phenyl]-N-methylcyclopentane-1-carboxamide
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C22H23N3O3
  1
1 IC50 = 200 nM
CP0564374
 Compound Info 
[4-(6-fluoro-1,3-benzoxazol-2-yl)phenyl]-[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]methanone
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C22H20FN3O4
  1
1 IC50 = 213 nM
CP0287007
 Compound Info 
(1R,3S)-N-[4-(1,3-benzoxazol-2-yl)phenyl]-3-[(2,2-difluoroacetyl)amino]-N-methylcyclopentane-1-carboxamide
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C22H21F2N3O3
  1
1 IC50 = 270 nM
CP0350261
 Compound Info 
(1R,3S)-N-[4-(1,3-benzoxazol-2-yl)phenyl]-3-(dimethylcarbamoylamino)-N-methylcyclopentane-1-carboxamide
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C23H26N4O3
  1
1 IC50 = 280 nM
CP0296583
 Compound Info 
(1R,3S)-N-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-N-methyl-3-(propanoylamino)cyclopentane-1-carboxamide
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C23H26N4O2
  1
1 IC50 = 290 nM
CP0294462
 Compound Info 
(1R,3S)-N-methyl-N-(4-phenylphenyl)-3-(propanoylamino)cyclopentane-1-carboxamide
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C22H26N2O2
  1
1 IC50 = 300 nM
CP0302414
 Compound Info 
(1R,3S)-N-methyl-N-[4-(1-methylbenzimidazol-2-yl)phenyl]-3-(propanoylamino)cyclopentane-1-carboxamide
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C24H28N4O2
  1
1 IC50 = 310 nM
CP0543768
 Compound Info 
[4-(2-chloro-4-fluorophenyl)phenyl]-[4-(1-hydroxycyclopropanecarbonyl)piperazin-1-yl]methanone
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C21H20ClFN2O3
  1
1 IC50 = 310 nM
CP0223900
 Compound Info 
(1R,3S)-N-[4-(1H-benzimidazol-2-yl)phenyl]-3-(ethylcarbamoylamino)-N-methylcyclopentane-1-carboxamide
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C23H27N5O2
  1
1 IC50 = 400 nM
CP0287543
 Compound Info 
(1R,3S)-N-[4-(1,3-benzoxazol-2-yl)phenyl]-3-(butanoylamino)-N-methylcyclopentane-1-carboxamide
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C24H27N3O3
  1
1 IC50 = 420 nM
CP0303924
 Compound Info 
(1R,3S)-N-methyl-3-(2-methylpropanoylamino)-N-(4-phenylphenyl)cyclopentane-1-carboxamide
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C23H28N2O2
  1
1 IC50 = 420 nM
CP0294461
 Compound Info 
(1R,3S)-3-acetamido-N-methyl-N-(4-phenylphenyl)cyclopentane-1-carboxamide
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C21H24N2O2
  1
1 IC50 = 480 nM
CP0304517
 Compound Info 
(1R,3S)-N-[4-(1,3-benzoxazol-2-yl)phenyl]-3-(ethylcarbamoylamino)-N-methylcyclopentane-1-carboxamide
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C23H26N4O3
  1
1 IC50 = 530 nM
CP0287542
 Compound Info 
(1R,3S)-N-[4-(1H-benzimidazol-2-yl)phenyl]-3-[6-(dimethylamino)hexanoylamino]-N-methylcyclopentane-1-carboxamide
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C28H37N5O2
  1
1 IC50 = 700 nM
CP0099943
 Compound Info 
(2R,3S)-3-((4E,7E)-Nona-4,7-dienoyl)-oxirane-2-carboxylic acid amide
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C12H17NO3
  3
1 IC50 = 850.987593 nM
2 IC50 = 5800 nM
3 IC50 = 13000 nM
CP0282485
 Compound Info 
(1R,3S)-N-[4-(1,3-benzoxazol-2-yl)phenyl]-3-[(2-methoxyacetyl)amino]-N-methylcyclopentane-1-carboxamide
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C23H25N3O4
  1
1 IC50 = 910 nM
CP0223899
 Compound Info 
(1R,3S)-3-acetamido-N-[4-(1H-benzimidazol-2-yl)phenyl]-N-methylcyclopentane-1-carboxamide
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C22H24N4O2
  1
1 IC50 = 1300 nM
CP0313632
 Compound Info 
(1R,3S)-3-(ethylcarbamoylamino)-N-methyl-N-[4-(1-methylbenzimidazol-2-yl)phenyl]cyclopentane-1-carboxamide
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C24H29N5O2
  1
1 IC50 = 1400 nM
CP0086453
 Compound Info 
(1R,3S)-N-[4-(1H-benzimidazol-2-yl)phenyl]-N-methyl-3-(2-methylpropanoylamino)cyclopentane-1-carboxamide
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C24H28N4O2
  1
1 IC50 = 1500 nM
CP0140881
 Compound Info 
(1R,3S)-3-(ethylcarbamoylamino)-N-methyl-N-(4-phenylphenyl)cyclopentane-1-carboxamide
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C22H27N3O2
  1
1 IC50 = 1500 nM
CP0226761
 Compound Info 
(1R,3S)-3-[6-(dimethylamino)hexanoylamino]-N-methyl-N-(4-phenylphenyl)cyclopentane-1-carboxamide
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C27H37N3O2
  1
1 IC50 = 2000 nM
CP0280134
 Compound Info 
(1R,3S)-3-[6-(dimethylamino)hexanoylamino]-N-methyl-N-[4-(1-methylbenzimidazol-2-yl)phenyl]cyclopentane-1-carboxamide
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C29H39N5O2
  1
1 IC50 = 2400 nM
CP0058220
 Compound Info 
(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl (2S)-2-formamido-4-methylpentanoate
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C29H53NO5
  1
1 IC50 = 4630 nM
CP0058738
 Compound Info 
2-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylsulfinyl]-1H-benzimidazole
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C16H14F3N3O2S
  3
1 IC50 = 46700 nM
2 Ki = 1700 nM
3 Ki = 5300 nM
CP0335553
 Compound Info 
(2R,3S)-4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
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C14H22O4
  1
1 IC50 = 59000 nM
Clinical Information about the Protein
Target 1 ( Fatty acid synthase (FASN) )
Target Type Successful Target
Disease 4 Target-related Diseases  4
1 Weight loss [ICD-11: MG43.5]
2 Hepatic fibrosis [ICD-11: DB93.0]
3 Non-alcoholic fatty liver disease [ICD-11: DB92]
4 Obesity [ICD-11: 5B81]
Approved Drug(s) 1 Approved Drug  1
1 Cerulenin
 Drug Info 
Approved
Weight loss
Clinical Trial Drug(s) 2 Clinical Trial Drugs  2
1 Epigallocatechin gallate
 Drug Info 
Phase 3
Hepatic fibrosis
2 TVB-2640
 Drug Info 
Phase 2
Non-alcoholic fatty liver disease
Investigative Drug(s) 1 Investigative Drug  1
1 C75
 Drug Info 
Investigative
Obesity