Protein Information

General Information of the Protein

Protein ID	PT02766
Protein Name	Sodium- and chloride-dependent glycine transporter 1
Secondarily Protein Name	Solute carrier family 6 member 9
Gene Name	SLC6A9
Sequence	MAVAHGPVATSSPEQNGAVPSEATKKDQNLTRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLVFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTPDCAGVLDASNLTNGSRPTALSGNLSHLFNYTLQRTSPSEEYWRLYVLKLSDDIGDFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFTGIMYYLTPKWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVSIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPTIIFFILIFTVIQYRPITYNHYQYPGWAVAIGFLMALSSVICIPLYALFQLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTTTPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI Show/Hide
Organism	Rattus norvegicus, Rat
Protein Classification	Transporter > Electrochemical transporter > SLC superfamily of solute carriers > SLC06 neurotransmitter transporter family
Function	Sodium- and chloride-dependent glycine transporter (PubMed:1534013, PubMed:16181645). Essential for regulating glycine concentrations at inhibitory glycinergic synapses (By similarity). Show/Hide
Uniprot ID	Primary ID: P28572 Secondarily ID: A1A5N0 Q63322 Q63323 Show/Hide
Ensembl ID	ENSG00000196517
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000049 , C6

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0285142 Compound Info	(R)-2-((3-(biphenyl-4-yloxy)-3-(4-fluorophenyl)propyl)(methyl)amino)acetic acid Show/Hide	C24H24FNO3	1
1	IC50 = 8.9 nM Bioactivity Info	TI LI LO TS
CP0106003 Compound Info	4-Benzyloxy-N-(1-dimethylamino-cyclopentylmethyl)-3,5-dimethoxy-benzamide Show/Hide	C24H32N2O4	1
1	IC50 = 22 nM Bioactivity Info	TI LI LO TS
CP0410012 Compound Info	5-Biphenyl-4-yl-4-(2-fluorophenyl)-N-methyl-4H-1,2,4-triazol-3-amine Show/Hide	C21H17FN4	1
1	IC50 = 83 nM Bioactivity Info	TI LI LO TS
CP0379616 Compound Info	2-(3-Biphenyl-4-yl-5-methyl-4H-1,2,4-triazole-4-yl)benzonitrile Show/Hide	C22H16N4	1
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0490027 Compound Info	5-[5-ethyl-4-(2-fluorophenyl)-1,2,4-triazol-3-yl]-2-phenylpyridine Show/Hide	C21H17FN4	1
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0379732 Compound Info	3-Biphenyl-4-yl-4-(2-fluorophenyl)-5-methyl-4H-1,2,4-triazole Show/Hide	C21H16FN3	1
1	IC50 = 190 nM Bioactivity Info	TI LI LO TS
CP0379733 Compound Info	3-Biphenyl-4-yl-4-(2-chlorophenyl)-5-methyl-4H-1,2,4-triazole Show/Hide	C21H16ClN3	1
1	IC50 = 190 nM Bioactivity Info	TI LI LO TS
CP0373521 Compound Info	3-Biphenyl-4-yl-5-ethyl-4-(2-fluorophenyl)-1,2,4-triazole Show/Hide	C22H18FN3	1
1	IC50 = 220 nM Bioactivity Info	TI LI LO TS
CP0500543 Compound Info	2-(3-(biphenyl-4-yl)-5-methyl-4H-1,2,4-triazol-4-yl)phenol Show/Hide	C21H17N3O	1
1	IC50 = 240 nM Bioactivity Info	TI LI LO TS
CP0510502 Compound Info	[3-[3-ethyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]-2-methylphenyl]methanol Show/Hide	C24H23N3O	1
1	IC50 = 250 nM Bioactivity Info	TI LI LO TS
CP0425665 Compound Info	3-Biphenyl-4-yl-5-methyl-4-(2-methylphenyl)-4H-1,2,4-triazole Show/Hide	C22H19N3	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0467489 Compound Info	8-[3-ethyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]quinoline Show/Hide	C25H20N4	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0426698 Compound Info	3-ethyl-4-(2-methylphenyl)-5-(4-phenylphenyl)-1,2,4-triazole Show/Hide	C23H21N3	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0487410 Compound Info	3-[3-ethyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]-2-methylaniline Show/Hide	C23H22N4	1
1	IC50 = 320 nM Bioactivity Info	TI LI LO TS
CP0487409 Compound Info	3-[3-ethyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]-2-methylphenol Show/Hide	C23H21N3O	1
1	IC50 = 340 nM Bioactivity Info	TI LI LO TS
CP0051811 Compound Info	3-Biphenyl-4-yl-4-(2-fluorophenyl)-5-isopropyl-4H-1,2,4-triazole Show/Hide	C23H20FN3	1
1	IC50 = 370 nM Bioactivity Info	TI LI LO TS
CP0426699 Compound Info	5-[3-ethyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]isoquinoline Show/Hide	C25H20N4	1
1	IC50 = 370 nM Bioactivity Info	TI LI LO TS
CP0425664 Compound Info	3-Biphenyl-4-yl-5-methyl-4-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazole Show/Hide	C22H16F3N3	1
1	IC50 = 390 nM Bioactivity Info	TI LI LO TS
CP0466009 Compound Info	3-[3-ethyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]-2-methylbenzonitrile Show/Hide	C24H20N4	1
1	IC50 = 490 nM Bioactivity Info	TI LI LO TS
CP0511752 Compound Info	3-Biphenyl-4-yl-4-(2-fluorophenyl)-5-methoxy-4H-1,2,4-triazole Show/Hide	C21H16FN3O	1
1	IC50 = 510 nM Bioactivity Info	TI LI LO TS
CP0426697 Compound Info	3-ethyl-4-(3-fluoro-2-methylphenyl)-5-(4-phenylphenyl)-1,2,4-triazole Show/Hide	C23H20FN3	1
1	IC50 = 630 nM Bioactivity Info	TI LI LO TS
CP0487411 Compound Info	2-[5-ethyl-4-(2-fluorophenyl)-1,2,4-triazol-3-yl]-5-phenylpyridine Show/Hide	C21H17FN4	1
1	IC50 = 700 nM Bioactivity Info	TI LI LO TS
CP0524102 Compound Info	8-[3-ethyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]isoquinoline Show/Hide	C25H20N4	1
1	IC50 = 800 nM Bioactivity Info	TI LI LO TS
CP0490028 Compound Info	3-ethyl-4-(2-methyl-3-nitrophenyl)-5-(4-phenylphenyl)-1,2,4-triazole Show/Hide	C23H20N4O2	1
1	IC50 = 800 nM Bioactivity Info	TI LI LO TS
CP0499471 Compound Info	5-[3-ethyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]quinoline Show/Hide	C25H20N4	1
1	IC50 = 820 nM Bioactivity Info	TI LI LO TS
CP0443873 Compound Info	2-[4-[4-(2-fluorophenyl)-5-methyl-1,2,4-triazol-3-yl]phenyl]pyridine Show/Hide	C20H15FN4	1
1	IC50 = 860 nM Bioactivity Info	TI LI LO TS
CP0389819 Compound Info	3-Biphenyl-4-yl-5-methyl-4-phenyl-4H-1,2,4-triazole Show/Hide	C21H17N3	1
1	IC50 = 880 nM Bioactivity Info	TI LI LO TS
CP0474400 Compound Info	3-Biphenyl-4-yl-4-(2-ethylphenyl)-5-methyl-4H-1,2,4-triazole Show/Hide	C23H21N3	1
1	IC50 = 920 nM Bioactivity Info	TI LI LO TS
CP0498956 Compound Info	4-(2,3-dimethylphenyl)-3-ethyl-5-(4-phenylphenyl)-1,2,4-triazole Show/Hide	C24H23N3	1
1	IC50 = 940 nM Bioactivity Info	TI LI LO TS
CP0478498 Compound Info	3-Biphenyl-4-yl-4-(2-fluorophenyl)-5-(methylsulfanyl)-4H-1,2,4-triazole Show/Hide	C21H16FN3S	1
1	IC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0451229 Compound Info	1-[3-ethyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]isoquinoline Show/Hide	C25H20N4	1
1	IC50 = 1400 nM Bioactivity Info	TI LI LO TS
CP0454820 Compound Info	4-[3-ethyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]quinoline Show/Hide	C25H20N4	1
1	IC50 = 1700 nM Bioactivity Info	TI LI LO TS
CP0402966 Compound Info	3-Biphenyl-4-yl-4-(2-methoxy-phenyl)-5-methyl-4H-[1,2,4]triazole Show/Hide	C22H19N3O	1
1	IC50 = 1800 nM Bioactivity Info	TI LI LO TS
CP0458320 Compound Info	4-(3-bromo-2-methylphenyl)-3-ethyl-5-(4-phenylphenyl)-1,2,4-triazole Show/Hide	C23H20BrN3	1
1	IC50 = 2200 nM Bioactivity Info	TI LI LO TS
CP0540338 Compound Info	4-(3-chloro-2-methylphenyl)-3-ethyl-5-(4-phenylphenyl)-1,2,4-triazole Show/Hide	C23H20ClN3	1
1	IC50 = 2200 nM Bioactivity Info	TI LI LO TS
CP0528507 Compound Info	3-Biphenyl-4-yl-4-(2-fluorophenyl)-4H-1,2,4-triazole Show/Hide	C20H14FN3	1
1	IC50 = 2300 nM Bioactivity Info	TI LI LO TS
CP0490026 Compound Info	3-ethyl-4-[3-(methoxymethyl)-2-methylphenyl]-5-(4-phenylphenyl)-1,2,4-triazole Show/Hide	C25H25N3O	1
1	IC50 = 2400 nM Bioactivity Info	TI LI LO TS
CP0410082 Compound Info	3-Biphenyl-4-yl-5-tert-butyl-4-(2-fluorophenyl)-4H-1,2,4-triazole Show/Hide	C24H22FN3	1
1	IC50 = 2600 nM Bioactivity Info	TI LI LO TS
CP0379654 Compound Info	1-[5-ethyl-4-(2-fluorophenyl)-1,2,4-triazol-3-yl]-4-phenylpiperazine Show/Hide	C20H22FN5	1
1	IC50 = 2600 nM Bioactivity Info	TI LI LO TS
CP0524101 Compound Info	4-[3-ethyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]-1H-indazole Show/Hide	C23H19N5	1
1	IC50 = 2800 nM Bioactivity Info	TI LI LO TS
CP0540337 Compound Info	2-[3-[3-ethyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]-2-methylphenyl]acetonitrile Show/Hide	C25H22N4	1
1	IC50 = 2800 nM Bioactivity Info	TI LI LO TS
CP0410035 Compound Info	3-Biphenyl-4-yl-4-(3-fluorophenyl)-5-methyl-4H-1,2,4-triazole Show/Hide	C21H16FN3	1
1	IC50 = 3000 nM Bioactivity Info	TI LI LO TS
CP0476607 Compound Info	7-[3-ethyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]-1-methylindole Show/Hide	C25H22N4	1
1	IC50 = 3000 nM Bioactivity Info	TI LI LO TS
CP0408477 Compound Info	3-[3-ethyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]-N,N,2-trimethylaniline Show/Hide	C25H26N4	1
1	IC50 = 3100 nM Bioactivity Info	TI LI LO TS
CP0400752 Compound Info	4-[3-ethyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]isoquinoline Show/Hide	C25H20N4	1
1	IC50 = 3700 nM Bioactivity Info	TI LI LO TS
CP0510503 Compound Info	1-[5-ethyl-4-(2-fluorophenyl)-1,2,4-triazol-3-yl]-4-phenylpiperidine Show/Hide	C21H23FN4	1
1	IC50 = 3700 nM Bioactivity Info	TI LI LO TS
CP0425666 Compound Info	3-Biphenyl-4-yl-5-methyl-4-(2-propylphenyl)-4H-1,2,4-triazole Show/Hide	C24H23N3	1
1	IC50 = 3800 nM Bioactivity Info	TI LI LO TS
CP0510501 Compound Info	3-[3-ethyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]-2-methylbenzamide Show/Hide	C24H22N4O	1
1	IC50 = 3900 nM Bioactivity Info	TI LI LO TS
CP0553362 Compound Info	methyl 3-[3-ethyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]-2-methylbenzoate Show/Hide	C25H23N3O2	1
1	IC50 = 5100 nM Bioactivity Info	TI LI LO TS
CP0413190 Compound Info	3-Biphenyl-4-yl-4-cyclohexyl-5-methyl-4H-1,2,4-triazole Show/Hide	C21H23N3	1
1	IC50 = 5200 nM Bioactivity Info	TI LI LO TS
CP0454819 Compound Info	7-[3-ethyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]-1H-indazole Show/Hide	C23H19N5	1
1	IC50 = 5600 nM Bioactivity Info	TI LI LO TS
CP0487412 Compound Info	4-[4-[4-(2-fluorophenyl)-5-methyl-1,2,4-triazol-3-yl]phenyl]pyridine Show/Hide	C20H15FN4	1
1	IC50 = 5900 nM Bioactivity Info	TI LI LO TS
CP0413192 Compound Info	3-Biphenyl-4-yl-4-(2-fluorophenyl)-5-(methylsulfonyl)-4H-1,2,4-triazole Show/Hide	C21H16FN3O2S	1
1	IC50 = 6500 nM Bioactivity Info	TI LI LO TS
CP0510430 Compound Info	4-[5-ethyl-4-(2-fluorophenyl)-1,2,4-triazol-3-yl]-1-phenylpiperidine Show/Hide	C21H23FN4	1
1	IC50 = 6600 nM Bioactivity Info	TI LI LO TS
CP0379652 Compound Info	3-[4-[4-(2-fluorophenyl)-5-methyl-1,2,4-triazol-3-yl]phenyl]pyridine Show/Hide	C20H15FN4	1
1	IC50 = 7000 nM Bioactivity Info	TI LI LO TS
CP0525081 Compound Info	4-[3-ethyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]-1H-benzimidazole Show/Hide	C23H19N5	1
1	IC50 = 7500 nM Bioactivity Info	TI LI LO TS
CP0437403 Compound Info	3-(4-Cyclohexylphenyl)-4-(2-fluorophenyl)-5-methyl-4H-1,2,4-triazole Show/Hide	C21H22FN3	1
1	IC50 = 9800 nM Bioactivity Info	TI LI LO TS
CP0410037 Compound Info	3-Biphenyl-4-yl-4-(2-fluorophenyl)-5-trifluoromethyl-4H-1,2,4-triazole Show/Hide	C21H13F4N3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0413191 Compound Info	4-Biphenyl-2-yl-3-biphenyl-4-yl-5-methyl-4H-1,2,4-triazole Show/Hide	C27H21N3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0392861 Compound Info	5-[3-ethyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]-2-oxidoisoquinolin-2-ium Show/Hide	C25H20N4O	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0451230 Compound Info	5-[3-ethyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]-2H-isoquinolin-1-one Show/Hide	C25H20N4O	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0467490 Compound Info	4-[[3-ethyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]methyl]pyridine Show/Hide	C22H20N4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0488409 Compound Info	5-[3-ethyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]-1,2,3,4-tetrahydroisoquinoline Show/Hide	C25H24N4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0495625 Compound Info	4-[1-[3-ethyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]ethyl]pyridine Show/Hide	C23H22N4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0490025 Compound Info	3-ethyl-4-[2-methyl-3-(trifluoromethyl)phenyl]-5-(4-phenylphenyl)-1,2,4-triazole Show/Hide	C24H20F3N3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0410081 Compound Info	3-Biphenyl-4-yl-4-(2-isopropylphenyl)-5-methyl-4H-1,2,4-triazole Show/Hide	C24H23N3	1
1	IC50 = 11000 nM Bioactivity Info	TI LI LO TS
CP0499470 Compound Info	7-[3-ethyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]-1H-indole Show/Hide	C24H20N4	1
1	IC50 = 22000 nM Bioactivity Info	TI LI LO TS
CP0501754 Compound Info	3-(Biphenyl-4-yl-methyl)-4-(2-fluorophenyl)-5-methyl-4H-1,2,4-triazole Show/Hide	C22H18FN3	1
1	IC50 = 27000 nM Bioactivity Info	TI LI LO TS
CP0538959 Compound Info	1-[3-[3-ethyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]-2-methylphenyl]-N,N-dimethylmethanamine Show/Hide	C26H28N4	1
1	IC50 = 29000 nM Bioactivity Info	TI LI LO TS
CP0501322 Compound Info	3-Biphenyl-4-yl-4-(4-fluorophenyl)-5-methyl-4H-1,2,4-triazole Show/Hide	C21H16FN3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0478497 Compound Info	3-Biphenyl-4-yl-4-isopropyl-5-methyl-4H-1,2,4-triazol Show/Hide	C18H19N3	1
1	IC50 = 35000 nM Bioactivity Info	TI LI LO TS
CP0538813 Compound Info	3-Biphenyl-2-yl-4-(2-fluorophenyl)-5-methyl-4H-1,2,4-triazole Show/Hide	C21H16FN3	1
1	IC50 = 62000 nM Bioactivity Info	TI LI LO TS
CP0503791 Compound Info	3-Biphenyl-3-yl-4-(2-fluorophenyl)-5-methyl-4H-1,2,4-triazole Show/Hide	C21H16FN3	1
1	IC50 = 70000 nM Bioactivity Info	TI LI LO TS
CP0379618 Compound Info	4-(2-Fluorophenyl)-3-methyl-5-phenyl-4H-1,2,4-triazole Show/Hide	C15H12FN3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT02185	Sodium- and chloride-dependent glycine transporter 1	Homo sapiens, Human	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han