General Information of the Protein
| Protein ID |
PT02569
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| Protein Name |
Kallikrein-14
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| Secondarily Protein Name |
Kallikrein-like protein 6
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| Gene Name |
KLK14
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| Secondarily Gene Name |
KLKL6
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| Sequence |
MSLRVLGSGTWPSAPKMFLLLTALQVLAIAMTQSQEDENKIIGGHTCTRSSQPWQAALLAGPRRRFLCGGALLSGQWVITAAHCGRPILQVALGKHNLRRWEATQQVLRVVRQVTHPNYNSRTHDNDLMLLQLQQPARIGRAVRPIEVTQACASPGTSCRVSGWGTISSPIARYPASLQCVNINISPDEVCQKAYPRTITPGMVCAGVPQGGKDSCQGDSGGPLVCRGQLQGLVSWGMERCALPGYPGVYTNLCKYRSWIEETMRDK
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| Organism |
Homo sapiens, Human
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| Protein Classification |
Enzyme
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Protease
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Serine protease
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Serine protease PA clan
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Serine protease S1A subfamily
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| Function |
Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis.
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| Uniprot ID |
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| Ensembl ID | |||||
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| Subcellular Location |
Secreted
Extracellular space
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000265 , NS0
Cell Line ID: CL000013 , Sf9
Clinical Information about the Protein
Target 1 ( Kallikrein-14 (KLK14) )
| Target Type | Patented-recorded Target | ||||
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