General Information of the Protein
| Protein ID |
PT02465
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| Protein Name |
Lactoylglutathione lyase
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| Secondarily Protein Name |
Aldoketomutase
Glyoxalase I
Ketone-aldehyde mutase
Methylglyoxalase
S-D-lactoylglutathione methylglyoxal lyase
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| Gene Name |
GLO1
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| Sequence |
MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLIQKCDFPIMKFSLYFLAYEDKNDIPKEKDEKIAWALSRKATLELTHNWGTEDDETQSYHNGNSDPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKMATLM
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| Organism |
Homo sapiens, Human
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| Protein Classification |
Enzyme
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Lyase
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| Function |
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (PubMed:20454679, PubMed:9705294, PubMed:23122816). Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (PubMed:19199007). Required for normal osteoclastogenesis (By similarity).
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| Uniprot ID |
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| Ensembl ID | |||||
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Clinical Information about the Protein