General Information of the Protein
Protein ID
PT02436
Protein Name
G-protein coupled receptor 52
Gene Name
GPR52
Sequence
MNESRWTEWRILNMSSGIVNVSERHSCPLGFGHYSVVDVCIFETVVIVLLTFLIIAGNLTVIFVFHCAPLLHHYTTSYFIQTMAYADLFVGVSCLVPTLSLLHYSTGVHESLTCQVFGYIISVLKSVSMACLACISVDRYLAITKPLSYNQLVTPCRLRICIILIWIYSCLIFLPSFFGWGKPGYHGDIFEWCATSWLTSAYFTGFIVCLLYAPAAFVVCFTYFHIFKICRQHTKEINDRRARFPSHEVDSSRETGHSPDRRYAMVLFRITSVFYMLWLPYIIYFLLESSRVLDNPTLSFLTTWLAISNSFCNCVIYSLSNSVFRLGLRRLSETMCTSCMCVKDQEAQEPKPRKRANSCSI
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
Function
Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (PubMed:24587241). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228).
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Uniprot ID
Primary ID:
Q9Y2T5

Secondarily ID:
O75654
Q4VBL6
Q6ISM0
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HGNC ID
HGNC:4508
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0416475
 Compound Info 
N-(2-hydroxyethyl)-3-methyl-1-[2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzothiophen-7-yl]pyrazole-4-carboxamide
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C23H20F3N3O2S
  1
1
EC50 = 5.2 nM
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CP0476663
 Compound Info 
N-(2-methoxyethyl)-3-methyl-1-[2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzothiophen-7-yl]pyrazole-4-carboxamide
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C24H22F3N3O2S
  1
1
EC50 = 9.6 nM
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CP0539172
 Compound Info 
4-[2-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-4-methyl-1,3-thiazol-5-yl]-2-methylbenzamide
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C20H16F4N2OS
  1
1
EC50 = 11 nM
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CP0466025
 Compound Info 
N-(2-hydroxyethyl)-3,5-dimethyl-1-[2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzothiophen-7-yl]pyrazole-4-carboxamide
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C24H22F3N3O2S
  1
1
EC50 = 15 nM
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CP0511769
 Compound Info 
N-(2-methoxyethyl)-3,5-dimethyl-1-[2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzothiophen-7-yl]pyrazole-4-carboxamide
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C25H24F3N3O2S
  1
1
EC50 = 17 nM
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CP0416474
 Compound Info 
N-(2-hydroxyethyl)-5-(hydroxymethyl)-3-methyl-1-[2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzothiophen-7-yl]pyrazole-4-carboxamide
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C24H22F3N3O3S
  1
1
EC50 = 21 nM
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CP0419766
 Compound Info 
4-[5-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-2-methylpyrazol-3-yl]-2-methylbenzamide
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C20H17F4N3O
  1
1
EC50 = 23 nM
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CP0419767
 Compound Info 
4-[2-[(3-chloro-5-fluorophenyl)methyl]-4-methyl-1,3-thiazol-5-yl]-2-methylbenzamide
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C19H16ClFN2OS
  1
1
EC50 = 25 nM
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CP0398813
 Compound Info 
N-(2-hydroxyethyl)-3-[2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzofuran-4-yl]benzamide
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C25H20F3NO3
  1
1
EC50 = 28.18 nM
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CP0334329
 Compound Info 
3-[2-[(3-chloro-5-fluorophenyl)methyl]-1-benzothiophen-7-yl]-N-(2-methoxyethyl)benzamide
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C25H21ClFNO2S
  1
1
EC50 = 29.51 nM
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CP0523051
 Compound Info 
N-(2-hydroxyethyl)-3-[2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzofuran-7-yl]benzamide
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C25H20F3NO3
  1
1
EC50 = 34.67 nM
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CP0532168
 Compound Info 
N-(2-hydroxyethyl)-3-[2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzothiophen-7-yl]benzamide
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C25H20F3NO2S
  1
1
EC50 = 37.15 nM
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CP0555255
 Compound Info 
N-(2-hydroxyethyl)-3-[2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzothiophen-4-yl]benzamide
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C25H20F3NO2S
  1
1
EC50 = 38.02 nM
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CP0555256
 Compound Info 
N-(2-hydroxyethyl)-3-[2-[[3-(trifluoromethyl)phenyl]methyl]indazol-4-yl]benzamide
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C24H20F3N3O2
  1
1
EC50 = 38.9 nM
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CP0475963
 Compound Info 
N-(2-methoxyethyl)-3-[2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzothiophen-7-yl]benzamide
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C26H22F3NO2S
  1
1
EC50 = 42.66 nM
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CP0466024
 Compound Info 
N-(2-hydroxyethyl)-2-methyl-5-[2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzothiophen-7-yl]pyrazole-3-carboxamide
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C23H20F3N3O2S
  1
1
EC50 = 45 nM
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CP0398817
 Compound Info 
N-(2-amino-2-oxoethyl)-3-[2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzothiophen-7-yl]benzamide
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C25H19F3N2O2S
  1
1
EC50 = 54.95 nM
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CP0407281
 Compound Info 
4-[4-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-2-methylimidazol-1-yl]-2-methylbenzamide
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C20H17F4N3O
  1
1
EC50 = 59 nM
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CP0547139
 Compound Info 
N-(2-methoxyethyl)-1-[2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzothiophen-7-yl]pyrazole-4-carboxamide
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C23H20F3N3O2S
  1
1
EC50 = 62 nM
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CP0578013
 Compound Info 
N-(2-methoxyethyl)-5-methyl-1-[2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzothiophen-7-yl]pyrazole-4-carboxamide
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C24H22F3N3O2S
  1
1
EC50 = 62 nM
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CP0398815
 Compound Info 
N-(2-hydroxyethyl)-3-[2-[[3-(trifluoromethyl)phenyl]methyl]indazol-7-yl]benzamide
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C24H20F3N3O2
  1
1
EC50 = 64.57 nM
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CP0414086
 Compound Info 
2-methyl-4-[4-methyl-2-[[3-(trifluoromethyl)phenyl]methyl]-1,3-thiazol-5-yl]benzamide
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C20H17F3N2OS
  1
1
EC50 = 73 nM
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CP0033447
 Compound Info 
4-[3-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-5-methyl-1,2,4-triazol-1-yl]-2-methylbenzamide
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C19H16F4N4O
  1
1
EC50 = 75 nM
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CP0398814
 Compound Info 
N-(2-hydroxyethyl)-3-[3-methyl-2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzofuran-7-yl]benzamide
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C26H22F3NO3
  1
1
EC50 = 81.28 nM
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CP0510805
 Compound Info 
2-ethyl-4-[4-methyl-2-[[3-(trifluoromethyl)phenyl]methyl]-1,3-thiazol-5-yl]benzamide
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C21H19F3N2OS
  1
1
EC50 = 83 nM
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CP0448356
 Compound Info 
N-(2-amino-2-oxoethyl)-3-[4-fluoro-2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzothiophen-7-yl]benzamide
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C25H18F4N2O2S
  1
1
EC50 = 83.18 nM
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CP0519760
 Compound Info 
N-(2-hydroxyethyl)-1-[2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzothiophen-7-yl]pyrazole-4-carboxamide
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C22H18F3N3O2S
  1
1
EC50 = 87 nM
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CP0547944
 Compound Info 
4-[4-methyl-2-[[3-(trifluoromethyl)phenyl]methyl]-1,3-thiazol-5-yl]-2-(trifluoromethyl)benzamide
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C20H14F6N2OS
  1
1
EC50 = 110 nM
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CP0543059
 Compound Info 
4-[2-[(3-chlorophenyl)methyl]-4-methyl-1,3-thiazol-5-yl]-2-methylbenzamide
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C19H17ClN2OS
  1
1
EC50 = 130 nM
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CP0519759
 Compound Info 
N-(2-hydroxyethyl)-3-(hydroxymethyl)-5-methyl-1-[2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzothiophen-7-yl]pyrazole-4-carboxamide
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C24H22F3N3O3S
  1
1
EC50 = 146 nM
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CP0402870
 Compound Info 
4-[2-[(3-methoxyphenyl)methyl]-4-methyl-1,3-thiazol-5-yl]-2-methylbenzamide
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C20H20N2O2S
  1
1
EC50 = 160 nM
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CP0407282
 Compound Info 
2-methoxy-4-[4-methyl-2-[[3-(trifluoromethyl)phenyl]methyl]-1,3-thiazol-5-yl]benzamide
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C20H17F3N2O2S
  1
1
EC50 = 170 nM
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CP0523053
 Compound Info 
N-(2-hydroxyethyl)-3-[2-[[3-(trifluoromethyl)phenyl]methyl]-2,3-dihydro-1-benzofuran-7-yl]benzamide
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C25H22F3NO3
  1
1
EC50 = 208.93 nM
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CP0432823
 Compound Info 
4-[2-[(4-chlorophenyl)methyl]-4-methyl-1,3-thiazol-5-yl]-2-methylbenzamide
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C19H17ClN2OS
  1
1
EC50 = 210 nM
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CP0447332
 Compound Info 
4-[4-methyl-2-[[3-(trifluoromethyl)phenyl]methyl]-1,3-thiazol-5-yl]benzamide
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C19H15F3N2OS
  1
1
EC50 = 220 nM
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CP0539173
 Compound Info 
4-[2-[(3-fluorophenyl)methyl]-4-methyl-1,3-thiazol-5-yl]-2-methylbenzamide
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C19H17FN2OS
  1
1
EC50 = 260 nM
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CP0419769
 Compound Info 
4-[4-methyl-2-[[3-(trifluoromethyl)phenyl]methyl]-1,3-thiazol-5-yl]-2-propan-2-ylbenzamide
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C22H21F3N2OS
  1
1
EC50 = 370 nM
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CP0543061
 Compound Info 
2-fluoro-4-[4-methyl-2-[[3-(trifluoromethyl)phenyl]methyl]-1,3-thiazol-5-yl]benzamide
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C19H14F4N2OS
  1
1
EC50 = 380 nM
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CP0565934
 Compound Info 
6-[4-methyl-2-[[3-(trifluoromethyl)phenyl]methyl]-1,3-thiazol-5-yl]pyridine-3-carboxamide
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C18H14F3N3OS
  1
1
EC50 = 400 nM
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CP0523052
 Compound Info 
N-(2-hydroxyethyl)-3-[2-[[3-(trifluoromethyl)phenyl]methyl]-2,3-dihydro-1-benzofuran-4-yl]benzamide
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C25H22F3NO3
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1
EC50 = 645.65 nM
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CP0558689
 Compound Info 
4-[2-[[3-(dimethylamino)phenyl]methyl]-4-methyl-1,3-thiazol-5-yl]-2-methylbenzamide
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C21H23N3OS
  1
1
EC50 = 690 nM
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CP0432830
 Compound Info 
3-methyl-4-[4-methyl-2-[[3-(trifluoromethyl)phenyl]methyl]-1,3-thiazol-5-yl]benzamide
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C20H17F3N2OS
  1
1
EC50 = 1400 nM
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CP0419768
 Compound Info 
4-[2-[(2-chlorophenyl)methyl]-4-methyl-1,3-thiazol-5-yl]-2-methylbenzamide
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C19H17ClN2OS
  1
1
EC50 = 3900 nM
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CP0489437
 Compound Info 
N-(2-hydroxyethyl)-3-[3-methyl-2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzofuran-4-yl]benzamide
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C26H22F3NO3
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1
EC50 > 10000 nM
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CP0865725
 Compound Info 
N-(3,4-dimethoxyphenethyl)-4-(4-methoxyphenyl)pyrimidin-2-amine
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C21H23N3O3
  1
1
EC50 > 10000 nM
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CP0030334
 Compound Info 
5-[4-methyl-2-[[3-(trifluoromethyl)phenyl]methyl]-1,3-thiazol-5-yl]pyridine-2-carboxamide
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C18H14F3N3OS
  1
1
EC50 > 1000 nM
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Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0033447
 Compound Info 
4-[3-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-5-methyl-1,2,4-triazol-1-yl]-2-methylbenzamide
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C19H16F4N4O
  1
1 EC50 = 93 nM
CP0030334
 Compound Info 
5-[4-methyl-2-[[3-(trifluoromethyl)phenyl]methyl]-1,3-thiazol-5-yl]pyridine-2-carboxamide
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C18H14F3N3OS
  1
1 EC50 > 1000 nM