General Information of the Protein
Protein ID
PT02407
Protein Name
Sterol O-acyltransferase 2
Secondarily
Protein Name
Acyl-coenzyme A:cholesterol acyltransferase 2
Cholesterol acyltransferase 2
Gene Name
SOAT2
Secondarily
Gene Name
ACACT2
ACAT2
Sequence
MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQLRELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTMLFLGQGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Transferase
Function
Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:16647063, PubMed:11294643). Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:11294643). Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA) as substrates (PubMed:11294643). May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa (PubMed:11294643).
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Uniprot ID
Primary ID:
O75908

Secondarily ID:
F5H7W4
I6L9H9
Q4VB99
Q4VBA1
Q96TD4
Q9UNR2
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HGNC ID
HGNC:11178
Subcellular Location
Endoplasmic reticulum membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000582 , AC29
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0844807
 Compound Info 
(R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-enyl 3-methylbutanoate
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C21H24O6
  1
1
IC50 = 800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000023 , BTI-Tn-5B1-4
 Cell Line Info 
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Cell Line ID: CL000063 , Hep-G2
 Cell Line Info 
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0186602
 Compound Info 
[(1S,2S,5S,6R,7R,9S,10S,18R)-5-acetyloxy-6-(acetyloxymethyl)-18-hydroxy-2,6,10-trimethyl-16-oxo-14-pyridin-3-yl-11,15-dioxatetracyclo[8.8.0.02,7.012,17]octadeca-12(17),13-dien-9-yl] 4-cyanobenzoate
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C37H38N2O10
  1
1 IC50 = 0.9 nM
CP0761592
 Compound Info 
Pyripyropene A
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C31H35NO10
  1
1 IC50 = 70 nM
CP0034055
 Compound Info 
(Z)-Octadec-9-enoic acid phenylamide
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C24H39NO
  1
1 IC50 = 170 nM
CP0115631
 Compound Info 
CHEMBL3233872
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C29H28N2O3
  1
1 IC50 = 3000 nM
CP0060386
 Compound Info 
CHEMBL3233884
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C29H30N2O4
  1
1 IC50 = 9700 nM
CP0285941
 Compound Info 
1-(3,4-Dimethoxy-phenyl)-2-[4-((2S,3R,4R,5S)-5-{4-[2-(3,4-dimethoxy-phenyl)-2-hydroxy-1-methyl-ethoxy]-3-methoxy-phenyl}-3,4-dimethyl-tetrahydro-furan-2-yl)-2-methoxy-phenoxy]-propan-1-ol
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C42H52O11
  1
1 IC50 = 39000 nM
Clinical Information about the Protein
Target 1 ( SOAT2 messenger RNA (SOAT2 mRNA) )
Target Type Literature-reported Target