General Information of the Protein
Protein ID
PT02364
Protein Name
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Secondarily
Protein Name
dUTP pyrophosphatase
Gene Name
DUT
Sequence
MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSAGRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLSEHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKHFIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTERGSGGFGSTGKN
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
Function
Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis (PubMed:17880943, PubMed:8631816, PubMed:8805593). Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor (By similarity). Essential for embryonic development (By similarity).
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Uniprot ID
Primary ID:
P33316

Secondarily ID:
A8K650
B4DPR5
O14785
Q16708
Q16860
Q6FHN1
Q6NSA3
Q96Q81
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Ensembl ID
ENSG00000128951
HGNC ID
HGNC:3078
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000162 , HeLa S3
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0558180
 Compound Info 
3-(2,2-difluoroethoxy)-N-[(E)-7-(2,4-dioxopyrimidin-1-yl)-2-methylhept-5-en-2-yl]benzenesulfonamide
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C20H25F2N3O5S
  1
1
EC50 = 49 nM
 Bioactivity Info 
   TI
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CP0395691
 Compound Info 
(E)-N-[(1R)-1-[3-(cyclopropylmethoxy)phenyl]ethyl]-5-(2,4-dioxopyrimidin-1-yl)pent-3-ene-1-sulfonamide
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C21H27N3O5S
  2
1
EC50 = 66 nM
 Bioactivity Info 
   TI
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2
IC50 = 38200 nM
 Bioactivity Info 
   TI
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CP0489079
 Compound Info 
3-(cyclopropylmethoxy)-N-[(E)-7-(2,4-dioxopyrimidin-1-yl)-2-methylhept-5-en-2-yl]benzenesulfonamide
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C22H29N3O5S
  1
1
EC50 = 71 nM
 Bioactivity Info 
   TI
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CP0523664
 Compound Info 
(E)-N-[(1R)-1-[3-(2,2-difluoroethoxy)phenyl]ethyl]-5-(2,4-dioxopyrimidin-1-yl)pent-3-ene-1-sulfonamide
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C19H23F2N3O5S
  1
1
EC50 = 96 nM
 Bioactivity Info 
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CP0482063
 Compound Info 
3-(2,2-difluoroethoxy)-N-[2-[4-[(2,4-dioxopyrimidin-1-yl)methyl]phenyl]propan-2-yl]benzenesulfonamide
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C22H23F2N3O5S
  1
1
EC50 = 100 nM
 Bioactivity Info 
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CP0523663
 Compound Info 
3-cyclopentyloxy-N-[2-[4-[(2,4-dioxopyrimidin-1-yl)methyl]phenyl]propan-2-yl]benzenesulfonamide
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C25H29N3O5S
  1
1
EC50 = 120 nM
 Bioactivity Info 
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CP0482062
 Compound Info 
3-(cyclopropylmethoxy)-N-[2-[4-[(2,4-dioxopyrimidin-1-yl)methyl]phenyl]propan-2-yl]benzenesulfonamide
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C24H27N3O5S
  1
1
EC50 = 140 nM
 Bioactivity Info 
   TI
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CP0353264
 Compound Info 
(E)-N-[(1R)-1-(3-cyclopentyloxyphenyl)ethyl]-5-(2,4-dioxopyrimidin-1-yl)pent-3-ene-1-sulfonamide
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C22H29N3O5S
  1
1
EC50 = 150 nM
 Bioactivity Info 
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CP0453335
 Compound Info 
3-cyclopentyloxy-N-[(E)-7-(2,4-dioxopyrimidin-1-yl)-2-methylhept-5-en-2-yl]benzenesulfonamide
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C23H31N3O5S
  1
1
EC50 = 200 nM
 Bioactivity Info 
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CP0527374
 Compound Info 
N-[(E)-7-(2,4-dioxopyrimidin-1-yl)-2-methylhept-5-en-2-yl]-3-methoxybenzenesulfonamide
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C19H25N3O5S
  1
1
EC50 = 450 nM
 Bioactivity Info 
   TI
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CP0403946
 Compound Info 
N-[(1R)-1-[3-(2,2-difluoroethoxy)phenyl]ethyl]-4-[(2,4-dioxopyrimidin-1-yl)methyl]benzenesulfonamide
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C21H21F2N3O5S
  1
1
EC50 = 610 nM
 Bioactivity Info 
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CP0530674
 Compound Info 
N-[(1R)-1-(3-cyclopentyloxyphenyl)ethyl]-4-[(2,4-dioxopyrimidin-1-yl)methyl]benzenesulfonamide
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C24H27N3O5S
  1
1
EC50 = 610 nM
 Bioactivity Info 
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CP0489080
 Compound Info 
N-[(1R)-1-[3-(cyclopropylmethoxy)phenyl]ethyl]-4-[(2,4-dioxopyrimidin-1-yl)methyl]benzenesulfonamide
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C23H25N3O5S
  1
1
EC50 = 930 nM
 Bioactivity Info 
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CP0395689
 Compound Info 
N-[(E)-7-(2,4-dioxopyrimidin-1-yl)-2-methylhept-5-en-2-yl]benzenesulfonamide
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C18H23N3O4S
  1
1
EC50 = 2600 nM
 Bioactivity Info 
   TI
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CP0482061
 Compound Info 
N-[2-[4-[(2,4-dioxopyrimidin-1-yl)methyl]phenyl]propan-2-yl]benzenesulfonamide
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C20H21N3O4S
  1
1
EC50 = 2600 nM
 Bioactivity Info 
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CP0300763
 Compound Info 
N-[2-[4-[(2,4-dioxopyrimidin-1-yl)methyl]phenyl]propan-2-yl]-3-methoxybenzenesulfonamide
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C21H23N3O5S
  1
1
EC50 = 3130 nM
 Bioactivity Info 
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CP0311588
 Compound Info 
N-[5-[(2,4-dioxopyrimidin-1-yl)methoxy]-2-methylpentan-2-yl]benzenesulfonamide
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C17H23N3O5S
  1
1
EC50 = 5100 nM
 Bioactivity Info 
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Biochemical Assays
Compound ID Compound Name Compound Formula
CP0194109
 Compound Info 
1-[4-[3-[(2R)-2-[3-(cyclopropylmethoxy)phenyl]butyl]triazol-4-yl]butyl]pyrimidine-2,4-dione
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C24H31N5O3
  1
1 IC50 = 29 nM
CP0395691
 Compound Info 
(E)-N-[(1R)-1-[3-(cyclopropylmethoxy)phenyl]ethyl]-5-(2,4-dioxopyrimidin-1-yl)pent-3-ene-1-sulfonamide
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C21H27N3O5S
  1
1 IC50 = 50 nM
CP0369289
 Compound Info 
1-[4-[3-[(2S)-2-[3-(cyclopropylmethoxy)-4-fluorophenyl]-2-hydroxybutyl]triazol-4-yl]butyl]pyrimidine-2,4-dione
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C24H30FN5O4
  1
1 IC50 = 67 nM
CP0353264
 Compound Info 
(E)-N-[(1R)-1-(3-cyclopentyloxyphenyl)ethyl]-5-(2,4-dioxopyrimidin-1-yl)pent-3-ene-1-sulfonamide
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C22H29N3O5S
  1
1 IC50 = 170 nM
CP0160657
 Compound Info 
1-[4-[3-[2-[3-(cyclopropylmethoxy)phenyl]ethyl]triazol-4-yl]butyl]pyrimidine-2,4-dione
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C22H27N5O3
  1
1 IC50 = 210 nM
CP0482062
 Compound Info 
3-(cyclopropylmethoxy)-N-[2-[4-[(2,4-dioxopyrimidin-1-yl)methyl]phenyl]propan-2-yl]benzenesulfonamide
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C24H27N3O5S
  1
1 IC50 = 240 nM
CP0282675
 Compound Info 
1-[3-[3-(2,2-diphenylethyl)triazol-4-yl]propyl]pyrimidine-2,4-dione
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C23H23N5O2
  1
1 IC50 = 1300 nM
CP0300763
 Compound Info 
N-[2-[4-[(2,4-dioxopyrimidin-1-yl)methyl]phenyl]propan-2-yl]-3-methoxybenzenesulfonamide
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C21H23N3O5S
  1
1 IC50 = 2570 nM
CP0482061
 Compound Info 
N-[2-[4-[(2,4-dioxopyrimidin-1-yl)methyl]phenyl]propan-2-yl]benzenesulfonamide
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C20H21N3O4S
  1
1 IC50 = 2690 nM
CP0311588
 Compound Info 
N-[5-[(2,4-dioxopyrimidin-1-yl)methoxy]-2-methylpentan-2-yl]benzenesulfonamide
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C17H23N3O5S
  2
1 IC50 = 3900 nM
2 IC50 = 9480 nM
Clinical Information about the Protein
Target 1 ( dUTP pyrophosphatase (DUT) )
Target Type Clinical trial Target
Disease 1 Target-related Disease  1
1 Non-small-cell lung cancer [ICD-11: 2C25.Y]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 TAS-114
 Drug Info 
Phase 2
Non-small-cell lung cancer