General Information of the Protein
Protein ID
PT02248
Protein Name
Catechol O-methyltransferase
Gene Name
COMT
Sequence
MPLAAVSLGLLLLALLLLLRHLGWGLVTIFWFEYVLQPVHNLIMGDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEMNPDYAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEKCGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPSSPDKS
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Organism
Rattus norvegicus, Rat
Protein Classification
Enzyme
>
Transferase
Function
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
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Uniprot ID
P22734
Ensembl ID
ENSG00000093010
Subcellular Location
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0159103
 Compound Info 
7-fluoro-5-pyrrolidin-1-ylsulfonylquinolin-8-ol
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C13H13FN2O3S
  1
1
IC50 < 1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0404794
 Compound Info 
7-fluoro-5-(4-fluorophenyl)sulfonylquinolin-8-ol
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C15H9F2NO3S
  1
1
IC50 < 1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0427211
 Compound Info 
5-cyclopentylsulfonyl-7-fluoroquinolin-8-ol
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C14H14FNO3S
  1
1
IC50 < 1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0483087
 Compound Info 
7-chloro-5-cyclopentylsulfonylquinolin-8-ol
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C14H14ClNO3S
  1
1
IC50 < 1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000154 , HEK293-EBNA1-6E
 Cell Line Info