General Information of the Protein
Protein ID
PT02189
Protein Name
Protein arginine N-methyltransferase 3
Secondarily
Protein Name
Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3
Gene Name
PRMT3
Secondarily
Gene Name
HRMT1L3
Sequence
MCSLASGATGGRGAVENEEDLPELSDSGDEAAWEDEDDADLPHGKQQTPCLFCNRLFTSAEETFSHCKSEHQFNIDSMVHKHGLEFYGYIKLINFIRLKNPTVEYMNSIYNPVPWEKEEYLKPVLEDDLLLQFDVEDLYEPVSVPFSYPNGLSENTSVVEKLKHMEARALSAEAALARAREDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQEDEDGVYFSSYGHYGIHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISEPCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTVHKNKKDPRSLTVTLTLNNSTQTYGLQ
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Organism
Homo sapiens, Human
Protein Classification
Epigenetic regulator
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Writer
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Protein methyltransferase
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Protein arginine methyltransferase
Function
Protein-arginine N-methyltransferase that catalyzes both the monomethylation and asymmetric dimethylation of the guanidino nitrogens of arginine residues in target proteins, and therefore falls into the group of type I methyltransferases (Probable). May regulate retinoic acid synthesis and signaling by inhibiting ALDH1A1 retinal dehydrogenase activity (PubMed:33495566).
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Uniprot ID
Primary ID:
O60678

Secondarily ID:
A0A0A0MSN7
B4DUC7
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Ensembl ID
ENSG00000185238
HGNC ID
HGNC:30163
Subcellular Location
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000068 , A-549
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0231947
 Compound Info 
1-(7-fluoroisoquinolin-6-yl)-3-(2-oxo-2-pyrrolidin-1-ylethyl)urea
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C16H17FN4O2
  1
1
EC50 = 1600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0127979
 Compound Info 
1-isoquinolin-6-yl-3-(2-oxo-2-pyrrolidin-1-ylethyl)urea
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C16H18N4O2
  1
1
EC50 = 2000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0181806
 Compound Info 
1-isoquinolin-6-yl-3-[2-oxo-2-(3,3,4,4-tetrafluoropyrrolidin-1-yl)ethyl]urea
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C16H14F4N4O2
  1
1
EC50 = 2700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0181805
 Compound Info 
1-(7-methylisoquinolin-6-yl)-3-(2-oxo-2-pyrrolidin-1-ylethyl)urea
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C17H20N4O2
  1
1
EC50 = 4900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0127979
 Compound Info 
1-isoquinolin-6-yl-3-(2-oxo-2-pyrrolidin-1-ylethyl)urea
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C16H18N4O2
  3
1 IC50 = 19 nM
2 Kd = 53 nM
3 Kd = 85 nM
CP0231947
 Compound Info 
1-(7-fluoroisoquinolin-6-yl)-3-(2-oxo-2-pyrrolidin-1-ylethyl)urea
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C16H17FN4O2
  1
1 IC50 = 19 nM
CP0462227
 Compound Info 
1-[2-(2,5-dimethylpyrrolidin-1-yl)-2-oxoethyl]-3-isoquinolin-6-ylurea
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C18H22N4O2
  1
1 IC50 = 22 nM
CP0181806
 Compound Info 
1-isoquinolin-6-yl-3-[2-oxo-2-(3,3,4,4-tetrafluoropyrrolidin-1-yl)ethyl]urea
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C16H14F4N4O2
  1
1 IC50 = 24 nM
CP0181805
 Compound Info 
1-(7-methylisoquinolin-6-yl)-3-(2-oxo-2-pyrrolidin-1-ylethyl)urea
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C17H20N4O2
  1
1 IC50 = 36 nM
Clinical Information about the Protein
Target 1 ( Protein arginine methyltransferase 3 (PRMT3) )
Target Type Literature-reported Target