Brief Information of the Compound and Protein
Compound Name
1-isoquinolin-6-yl-3-(2-oxo-2-pyrrolidin-1-ylethyl)urea
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PubChem ID
CID: 90642938
Canonical SMILES
O=C(NCC(=O)N1CCCC1)Nc1ccc2cnccc2c1
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Compound Formula C16H18N4O2
Compound Structure
Protein Name
Protein arginine N-methyltransferase 3
Protein Classification
Epigenetic regulator
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Writer
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Protein methyltransferase
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Protein arginine methyltransferase
Uniprot ID
O60678
Gene Name
PRMT3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549 Homo sapiens (Human)  1
1
EC50 = 2000 nM
   TI
   LI
   LO
   TS
CL000006 HEK293 Homo sapiens (Human)  3
1
EC50 = 1800 nM
   TI
   LI
   LO
   TS
2
IC50 = 91 nM
   TI
   LI
   LO
   TS
3
IC50 = 225 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 19 nM
2 Kd = 53 nM
3 Kd = 85 nM