General Information of the Protein
Protein ID
PT02170
Protein Name
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
Secondarily
Protein Name
C2-PI3K
Phosphoinositide 3-kinase-C2-beta
Gene Name
PIK3C2B
Sequence
MSSTQGNGEHWKSLESVGISRKELAMAEALQMEYDALSRLRHDKEENRAKQNADPSLISWDEPGVDFYSKPAGRRTDLKLLRGLSGSDPTLNYNSLSPQEGPPNHSTSQGPQPGSDPWPKGSLSGDYLYIFDGSDGGVSSSPGPGDIEGSCKKLSPPPLPPRASIWDTPPLPPRKGSPSSSKISQPSDINTFSLVEQLPGKLLEHRILEEEEVLGGGGQGRLLGSVDYDGINDAITRLNLKSTYDAEMLRDATRGWKEGRGPLDFSKDTSGKPVARSKTMPPQVPPRTYASRYGNRKNATPGKNRRISAAPVGSRPHTVANGHELFEVSEERDEEVAAFCHMLDILRSGSDIQDYFLTGYVWSAVTPSPEHLGDEVNLKVTVLCDRLQEALTFTCNCSSTVDLLIYQTLCYTHDDLRNVDVGDFVLKPCGLEEFLQNKHALGSHEYIQYCRKFDIDIRLQLMEQKVVRSDLARTVNDDQSPSTLNYLVHLQERPVKQTISRQALSLLFDTYHNEVDAFLLADGDFPLKADRVVQSVKAICNALAAVETPEITSALNQLPPCPSRMQPKIQKDPSVLAVRENREKVVEALTAAILDLVELYCNTFNADFQTAVPGSRKHDLVQEACHFARSLAFTVYATHRIPIIWATSYEDFYLSCSLSHGGKELCSPLQTRRAHFSKYLFHLIVWDQQICFPVQVNRLPRETLLCATLYALPIPPPGSSSEANKQRRVPEALGWVTTPLFNFRQVLTCGRKLLGLWPATQENPSARWSAPNFHQPDSVILQIDFPTSAFDIKFTSPPGDKFSPRYEFGSLREEDQRKLKDIMQKESLYWLTDADKKRLWEKRYYCHSEVSSLPLVLASAPSWEWACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVRRMAVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKDGLKDSQFSIRYQYLLAALLCCCGKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGILRTGLEEVKQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRVIFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLIESSLGSVATKLNFFIHNLAQMKFTGSDDRLTLSFASRTHTLKSSGRISDVFLCRHEKIFHPNKGYIYVVKVMRENTHEATYIQRTFEEFQELHNKLRLLFPSSHLPSFPSRFVIGRSRGEAVAERRREELNGYIWHLIHAPPEVAECDLVYTFFHPLPRDEKAMGTSPAPKSSDGTWARPVGKVGGEVKLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQEKTGWFALGSRSHGTL
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Transferase
Function
Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns (PubMed:10805725, PubMed:9830063, PubMed:11533253). Does not phosphorylate PtdIns(4,5)P2 (PubMed:9830063). May be involved in EGF and PDGF signaling cascades (PubMed:10805725).
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Uniprot ID
Primary ID:
O00750

Secondarily ID:
O95666
Q5SW99
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Ensembl ID
ENSG00000133056
HGNC ID
HGNC:8972
Subcellular Location
Microsome
Cell membrane
Cytoplasm
Cytosol
Nucleus
Endoplasmic reticulum
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0642162
 Compound Info 
3-(4-morpholin-4-yl-pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl)-phenol
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C19H17ClN4O3
  1
1
IC50 = 10 nM
 Bioactivity Info 
   TI
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CP0845652
 Compound Info 
PIK-75
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C16H15BrClN5O4S
  1
1
IC50 = 100 nM
 Bioactivity Info 
   TI
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CP0640938
 Compound Info 
3-(4-morpholinothieno[3,2-d]pyrimidin-2-yl)phenol
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C16H16ClN3O2S
  1
1
IC50 = 220 nM
 Bioactivity Info 
   TI
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CP0002420
 Compound Info 
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
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C19H17NO3
  1
1
IC50 = 2100 nM
 Bioactivity Info 
   TI
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CP0891722
 Compound Info 
5-Ethyl-3-(10-morpholinoethyl)-6-thioxo-5,6,8,9,10,10ahexahydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidin-1(2H)-one
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C17H25N5O2S
  1
1
IC50 = 2670 nM
 Bioactivity Info 
   TI
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CP0849535
 Compound Info 
5-Phenyl-3-(morpholinomethyl)-6-thioxo-5,6,8,9,10,10a-hexahydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidin-1(2H)-one
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C20H23N5O2S
  1
1
IC50 = 4430 nM
 Bioactivity Info 
   TI
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CP0867448
 Compound Info 
5-Ethyl-3-(morpholinomethyl)-6-thioxo-5,6,8,9,10,10ahexahydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidin-1(2H)-one
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C16H23N5O2S
  1
1
IC50 = 5250 nM
 Bioactivity Info 
   TI
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CP0864151
 Compound Info 
3-(4-Methoxyphenyl)-5-ethyl-1-morpholino-6-thioxo-5,6,8,9,10,10a-hexahydropyrido[3,2-e]pyrrolo[1,2-c]pyrimidine-2-carbonitrile
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C24H27N5O2S
  1
1
IC50 = 8460 nM
 Bioactivity Info 
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CP0382537
 Compound Info 
8-ethyl-11-(3-hydroxy-4-methoxyphenyl)-13-morpholin-4-yl-7-sulfanylidene-6,8,10-triazatricyclo[7.4.0.02,6]trideca-1(9),10,12-triene-12-carbonitrile
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C24H27N5O3S
  1
1
IC50 = 8560 nM
 Bioactivity Info 
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CP0886055
 Compound Info 
3-(3,4-Dimethoxyphenyl)-5-ethyl-1-morpholino-6-thioxo-5,6,8,9,10,10a-hexahydropyrido[3,2-e]pyrrolo[1,2-c]pyrimidine-2-carbonitrile
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C25H29N5O3S
  1
1
IC50 = 8750 nM
 Bioactivity Info 
   TI
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CP0869038
 Compound Info 
5-Phenyl-3-(1'-morpholinoethyl)-6-thioxo-5,6,8,9,10,10ahexahydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidin-1(2H)-one
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C21H25N5O2S
  1
1
IC50 = 9450 nM
 Bioactivity Info 
   TI
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CP0869037
 Compound Info 
3-(3-Methoxyphenyl)-5-ethyl-1-morpholino-6-thioxo-5,6,8,9,10,10a-hexahydropyrido[3,2-e]pyrrolo[1,2-c]pyrimidine-2-carbonitrile
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C24H27N5O2S
  1
1
IC50 = 9760 nM
 Bioactivity Info 
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CP0865020
 Compound Info 
5-Ethyl-3-(4-methoxyphenyl)-1-morpholino-8,9,10,10a-tetrahydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidine-6(5H)-thione
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C22H27N5O2S
  1
1
IC50 = 13560 nM
 Bioactivity Info 
   TI
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CP0881577
 Compound Info 
3-(3-Methoxyphenyl)-1-morpholino-5-phenyl-8,9,10,10atetrahydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidine-6(5H)-thione
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C26H27N5O2S
  1
1
IC50 = 14560 nM
 Bioactivity Info 
   TI
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CP0865022
 Compound Info 
5-Ethyl-3-(3-methoxyphenyl)-1-morpholino-8,9,10,10a-tetrahydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidine-6(5H)-thione
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C22H27N5O2S
  1
1
IC50 = 20840 nM
 Bioactivity Info 
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CP0873710
 Compound Info 
1-Morpholino-3-(1'-morpholinoethyl)-5-phenyl-8,9,10,10ahexahydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidine-6(5H)-thione
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C25H32N6O2S
  1
1
IC50 = 28640 nM
 Bioactivity Info 
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CP0873711
 Compound Info 
1-Morpholino-3-(morpholinomethyl)-5-phenyl-8,9,10,10ahexahydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidine-6(5H)-thione
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C24H30N6O2S
  1
1
IC50 = 78780 nM
 Bioactivity Info 
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CP0869039
 Compound Info 
3-(3-Hydroxyphenyl)-5-ethyl-1-morpholino-6-thioxo-5,6,8,9,10,10a-hexahydropyrido[3,2-e]pyrrolo[1,2-c]pyrimidine-2-carbonitrile
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C23H25N5O2S
  1
1
IC50 = 81560 nM
 Bioactivity Info 
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CP0865021
 Compound Info 
3-(4-Methoxyphenyl)-1-morpholino-5-phenyl-8,9,10,10atetrahydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidine-6(5H)-thione
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C26H27N5O2S
  1
1
IC50 = 85540 nM
 Bioactivity Info 
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Biochemical Assays
Compound ID Compound Name Compound Formula
CP0642162
 Compound Info 
3-(4-morpholin-4-yl-pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl)-phenol
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C19H17ClN4O3
  1
1 IC50 = 10 nM
CP0066262
 Compound Info 
PIK90
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C18H17N5O3
  1
1 IC50 = 64 nM
CP0084875
 Compound Info 
N-[5-[4-chloro-3-(2-hydroxyethylsulfamoyl)phenyl]-4-methyl-1,3-thiazol-2-yl]acetamide
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C14H16ClN3O4S2
  1
1 IC50 = 140 nM
CP0640938
 Compound Info 
3-(4-morpholinothieno[3,2-d]pyrimidin-2-yl)phenol
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C16H16ClN3O2S
  1
1 IC50 = 220 nM
CP0268008
 Compound Info 
N-[2-[3-(benzenesulfonamido)phenyl]-4-morpholin-4-ylquinazolin-6-yl]acetamide
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C26H25N5O4S
  1
1 IC50 = 630 nM
CP0002420
 Compound Info 
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
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C19H17NO3
  2
1 IC50 = 2100 nM
2 IC50 = 10400 nM