General Information of the Protein
Protein ID
PT02085
Protein Name
Endothelin receptor type B
Secondarily
Protein Name
Endothelin receptor non-selective type
Gene Name
EDNRB
Sequence
MQSSASRCGRALVALLLACGLLGVWGEKRGFPPAQATPSLLGTKEVMTPPTKTSWTRGSNSSLMRSSAPAEVTKGGRVAGVPPRSFPPPCQRKIEINKTFKYINTIVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINAYKLLAGDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDVITSDYKGKPLRVCMLNPFQKTAFMQFYKTAKDWWLFSFYFCLPLAITAIFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQSNPQRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQTFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
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Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
Endothelin receptor
Function
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
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Uniprot ID
P21451
Ensembl ID
ENSG00000136160
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0094665
 Compound Info 
(S)-3-[(S)-2-((S)-2-Acetylamino-3,3-diphenyl-propionylamino)-4-methyl-pentanoylamino]-N-((1S,2S)-1-{(1S,2S)-1-[(S)-1-carboxy-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-methyl-butylcarbamoyl}-2-methyl-butyl)-succinamic acid
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C50H65N7O10
  1
1
IC50 = 20 nM
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CP0293980
 Compound Info 
(S)-N-((1S,2S)-1-{(1S,2S)-1-[(S)-1-Carboxy-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-methyl-butylcarbamoyl}-2-methyl-butyl)-3-{(S)-4-methyl-2-[(S)-2-(3-methyl-ureido)-3,3-diphenyl-propionylamino]-pentanoylamino}-succinamic acid
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C50H66N8O10
  1
1
IC50 = 20 nM
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CP0080355
 Compound Info 
(S)-N-((1S,2S)-1-{(1S,2S)-1-[(S)-1-Carboxy-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-methyl-butylcarbamoyl}-2-methyl-butyl)-3-[(S)-2-((S)-3,3-diphenyl-2-propionylamino-propionylamino)-4-methyl-pentanoylamino]-succinamic acid
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C51H67N7O10
  1
1
IC50 = 220 nM
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CP0307256
 Compound Info 
(S)-N-((1S,2S)-1-{(1S,2S)-1-[(S)-1-Carboxy-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-methyl-butylcarbamoyl}-2-methyl-butyl)-3-{(S)-2-[(S)-3,3-diphenyl-2-(2,2,2-trifluoro-acetylamino)-propionylamino]-4-methyl-pentanoylamino}-succinamic acid
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C50H62F3N7O10
  1
1
IC50 = 290 nM
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CP0320424
 Compound Info 
(S)-3-[(S)-2-((S)-2-Benzoylamino-3,3-diphenyl-propionylamino)-4-methyl-pentanoylamino]-N-((1S,2S)-1-{(1S,2S)-1-[(S)-1-carboxy-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-methyl-butylcarbamoyl}-2-methyl-butyl)-succinamic acid
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C55H67N7O10
  1
1
IC50 = 290 nM
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CP0051768
 Compound Info 
(S)-N-((1S,2S)-1-{(1S,2S)-1-[(S)-1-Carboxy-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-methyl-butylcarbamoyl}-2-methyl-butyl)-3-{(S)-2-[(S)-2-(cyclohexanecarbonyl-amino)-3,3-diphenyl-propionylamino]-4-methyl-pentanoylamino}-succinamic acid
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C55H73N7O10
  1
1
IC50 = 560 nM
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CP0046911
 Compound Info 
(S)-N-((1S,2S)-1-{(1S,2S)-1-[(S)-1-Carboxy-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-methyl-butylcarbamoyl}-2-methyl-butyl)-3-{(S)-2-[(S)-2-(2,2-dimethyl-propionylamino)-3,3-diphenyl-propionylamino]-4-methyl-pentanoylamino}-succinamic acid
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C53H71N7O10
  1
1
IC50 = 890 nM
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CP0152807
 Compound Info 
(S)-N-((1S,2S)-1-{(1S,2S)-1-[(S)-1-Carboxy-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-methyl-butylcarbamoyl}-2-methyl-butyl)-3-[(S)-2-((S)-2-methanesulfonylamino-3,3-diphenyl-propionylamino)-4-methyl-pentanoylamino]-succinamic acid
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C49H65N7O11S
  1
1
IC50 = 1300 nM
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CP0509991
 Compound Info 
(S)-N-((1S,2S)-1-{(1S,2S)-1-[(S)-1-Carboxy-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-methyl-butylcarbamoyl}-2-methyl-butyl)-3-((S)-2-{(S)-3,3-diphenyl-2-[(pyridine-3-carbonyl)-amino]-propionylamino}-4-methyl-pentanoylamino)-succinamic acid
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C54H66N8O10
  1
1
IC50 = 2500 nM
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CP0048328
 Compound Info 
(3S)-4-[[(2S,3S)-1-[[(2S,3S)-1-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-[[(2S)-2-[[(2S)-3,3-diphenyl-2-(tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene-2-carbonylamino)propanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoic acid
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C64H75N7O10
  1
1
IC50 = 3600 nM
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CP0307091
 Compound Info 
3-(2-{2-[(Adamantane-1-carbonyl)-amino]-3,3-diphenyl-propionylamino}-4-methyl-pentanoylamino)-N-(1-{1-[1-carboxy-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-methyl-butylcarbamoyl}-2-methyl-butyl)-succinamic acid
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C59H77N7O10
  1
1
IC50 = 4000 nM
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CP0168569
 Compound Info 
(S)-3-[(S)-2-((S)-2-Amino-3,3-diphenyl-propionylamino)-4-methyl-pentanoylamino]-N-((1S,2S)-1-{(1S,2S)-1-[(S)-1-carboxy-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-methyl-butylcarbamoyl}-2-methyl-butyl)-succinamic acid
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C48H63N7O9
  1
1
IC50 = 9200 nM
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CP0135125
 Compound Info 
(S)-N-((1S,2S)-1-{(1S,2S)-1-[(S)-1-Carboxy-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-methyl-butylcarbamoyl}-2-methyl-butyl)-3-{(S)-2-[(S)-2-(3-cyclohexyl-ureido)-3,3-diphenyl-propionylamino]-4-methyl-pentanoylamino}-succinamic acid
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C55H74N8O10
  1
1
IC50 = 9300 nM
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CP0319208
 Compound Info 
(S)-N-((1S,2S)-1-{(1S,2S)-1-[(S)-1-Carboxy-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-methyl-butylcarbamoyl}-2-methyl-butyl)-3-[(S)-2-((S)-2-diphenylacetylamino-3,3-diphenyl-propionylamino)-4-methyl-pentanoylamino]-succinamic acid
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C62H73N7O10
  1
1
IC50 = 9300 nM
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