General Information of the Protein
Protein ID
PT02038
Protein Name
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
Secondarily
Protein Name
Hcam3
Gene Name
PDE1C
Sequence
MESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSISSSDAKRSGVKTSGSEGSAPINNSVISVDYKSFKATWTEVVHINRERWRAKVPKEEKAKKEAEEKARLAAEEQQKEMEAKSQAEEGASGKAEKKTSGETKNQVNGTRANKSDNPRGKNSKAEKSSGEQQQNGDFKDGKNKTDKKDHSNIGNDSKKTDGTKQRSHGSPAPSTSSTCRLTLPVIKPPLRHFKRPAYASSSYAPSVSKKTDEHPARYKMLDQRIKMKKIQNISHNWNRK
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Phosphodiesterase
>
Phosphodiesterase 1
>
Phosphodiesterase 1C
Function
Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:8557689, PubMed:29860631). Has a high affinity for both cAMP and cGMP (PubMed:8557689). Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable).
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Uniprot ID
Primary ID:
Q14123

Secondarily ID:
B3KPC6
E9PE92
Q14124
Q8NB10
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HGNC ID
HGNC:8776
Subcellular Location
Lysosome
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0398541
 Compound Info 
6-benzyl-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
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C17H18N4O
  1
1
IC50 = 0.4 nM
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CP0487996
 Compound Info 
6-benzyl-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one
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C17H18N4O2
  1
1
IC50 = 14 nM
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CP0271210
 Compound Info 
6-[(3S,4S)-1-[(4-fluorophenyl)methyl]-4-methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one
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C22H26FN5O2
  1
1
IC50 = 165 nM
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CP0487995
 Compound Info 
6-[(3S,4S)-1-benzyl-4-ethylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one
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C23H29N5O2
  1
1
IC50 = 431 nM
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CP0486714
 Compound Info 
6-[(3S,4S)-1-[(4-methoxyphenyl)methyl]-4-methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one
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C23H29N5O3
  1
1
IC50 = 466 nM
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CP0486716
 Compound Info 
6-[(3S,4S)-1-[(3-fluorophenyl)methyl]-4-methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one
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C22H26FN5O2
  1
1
IC50 = 693 nM
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CP0543310
 Compound Info 
6-[(3S,4S)-1-[(2-fluorophenyl)methyl]-4-methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one
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C22H26FN5O2
  1
1
IC50 = 889 nM
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CP0441922
 Compound Info 
6-[(3S,4S)-4-methyl-1-[(6-methylpyridin-3-yl)methyl]pyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one
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C22H28N6O2
  1
1
IC50 = 979 nM
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CP0243948
 Compound Info 
6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one
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C20H25N7O2
  1
1
IC50 = 1394 nM
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CP0243949
 Compound Info 
6-[(3S,4S)-4-methyl-1-[(5-methylpyrazin-2-yl)methyl]pyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one
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C21H27N7O2
  1
1
IC50 = 1603 nM
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CP0523690
 Compound Info 
6-[(3S,4S)-4-methyl-1-(pyridin-2-ylmethyl)pyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one
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C21H26N6O2
  1
1
IC50 = 1858 nM
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CP0078267
 Compound Info 
6-[(3S,4S)-4-methyl-1-[(2-methylpyrimidin-5-yl)methyl]pyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one
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C21H27N7O2
  1
1
IC50 = 1872 nM
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CP0487994
 Compound Info 
6-[(3S,4S)-4-methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one
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C15H21N5O2
  1
1
IC50 = 3421 nM
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CP0486715
 Compound Info 
6-[(3R,4R)-1-benzyl-4-methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one
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C22H27N5O2
  1
1
IC50 = 5601 nM
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CP0248670
 Compound Info 
5,8-dimethyl-2-(2-phenylimidazo[1,2-a]pyrimidin-7-yl)-[1,2,4]triazolo[1,5-a]pyrazine
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C19H15N7
  1
1
IC50 > 10000 nM
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CP0366792
 Compound Info 
5,8-Dimethyl-2-(2-phenyl-1H-benzimidazol-5-yl)[1,2,4]triazolo[1,5-a]pyrazine
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C20H16N6
  1
1
IC50 > 10000 nM
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CP0389044
 Compound Info 
5,8-dimethyl-2-(2-pyridin-3-yl-3H-benzimidazol-5-yl)-[1,2,4]triazolo[1,5-a]pyrazine
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C19H15N7
  1
1
IC50 > 10000 nM
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CP0389045
 Compound Info 
2-[2-(5-chlorothiophen-2-yl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine
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C18H13ClN6S
  1
1
IC50 > 10000 nM
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CP0396021
 Compound Info 
5,8-dimethyl-2-(2-thiophen-2-yl-3H-benzimidazol-5-yl)-[1,2,4]triazolo[1,5-a]pyrazine
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C18H14N6S
  1
1
IC50 > 10000 nM
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CP0396022
 Compound Info 
5-[6-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-1H-benzimidazol-2-yl]-1,3-thiazole
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C17H13N7S
  1
1
IC50 > 10000 nM
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CP0396025
 Compound Info 
2-[2-(2-methoxyphenyl)imidazo[1,2-a]pyrimidin-7-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine
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C20H17N7O
  1
1
IC50 > 10000 nM
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CP0408074
 Compound Info 
2-[2-(3-bromophenyl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine
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C20H15BrN6
  1
1
IC50 > 10000 nM
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CP0408075
 Compound Info 
2-[2-(4-fluorophenyl)imidazo[1,2-a]pyrimidin-7-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine
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C19H14FN7
  1
1
IC50 > 10000 nM
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CP0408076
 Compound Info 
2-[2-(3-chlorophenyl)imidazo[1,2-a]pyrimidin-7-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine
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C19H14ClN7
  1
1
IC50 > 10000 nM
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CP0412213
 Compound Info 
2-[6-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-1H-benzimidazol-2-yl]-5-methyl-1,3-thiazole
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C18H15N7S
  1
1
IC50 > 10000 nM
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CP0412218
 Compound Info 
US10138245, Example 56
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C19H15N7
  1
1
IC50 > 10000 nM
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CP0412219
 Compound Info 
US10138245, Example 2
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C20H15FN6
  1
1
IC50 > 10000 nM
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CP0412220
 Compound Info 
2-[2-(2-Methoxyphenyl)-1H-benzimidazol-5-yl]-5,8-dimethyl[1,2,4]triazolo[1,5-a]pyrazine
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C21H18N6O
  1
1
IC50 > 10000 nM
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CP0482326
 Compound Info 
5,7-Dimethyl-2-(2-phenyl-1H-benzo[d]imidazol-5-yl)-[1,2,4]triazolo-[1,5-a]pyrimidine
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C20H16N6
  1
1
IC50 > 10000 nM
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CP0482327
 Compound Info 
5,8-Dimethyl-2-[2-(1,3-thiazol-2-yl)-1H-benz-imidazol-5-yl][1,2,4]triazolo[1,5-a]pyrazine
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C17H13N7S
  1
1
IC50 > 10000 nM
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CP0482328
 Compound Info 
2-[2-(4-FLuorophenyl)-1H-benzimidazol-5-yl]-5,8-dimethyl[1,2,4]triazolo[1,5-a]pyrazine
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C20H15FN6
  1
1
IC50 > 10000 nM
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CP0482329
 Compound Info 
2-[6-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-1H-benzimidazol-2-yl]-4-methyl-1,3-thiazole
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C18H15N7S
  1
1
IC50 > 10000 nM
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CP0513387
 Compound Info 
5,8-Dimethyl-2-[2-(pyridin-2-yl)-1H-benzimidazol-5-yl][1,2,4]triazolo[1,5-a]pyrazine
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C19H15N7
  1
1
IC50 > 10000 nM
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CP0513391
 Compound Info 
2-[2-(3-methoxypyridin-2-yl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine
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C20H17N7O
  1
1
IC50 > 10000 nM
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CP0555893
 Compound Info 
2-[2-(furan-2-yl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine
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C18H14N6O
  1
1
IC50 > 10000 nM
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CP0862252
 Compound Info 
2-(2-Bromophenyl)-7-{5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl}imidazo[1,2-a]pyrimidine
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C19H14BrN7
  1
1
IC50 > 10000 nM
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CP0865138
 Compound Info 
2-(7-{5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl}imidazo[1,2-a]pyrimidin-2-yl)pyridine
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C18H14N8
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1
IC50 > 10000 nM
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CP0865140
 Compound Info 
6-{5,8-Dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl}-2-(3-fluoropyridin-2-yl)-1H-1,3-benzodiazole
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C19H14FN7
  1
1
IC50 > 10000 nM
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CP0905292
 Compound Info 
2-(7-{5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl}imidazo[1,2-a]pyrimidin-2-yl)-1,3-thiazole
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C16H12N8S
  1
1
IC50 > 10000 nM
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CP0476999
 Compound Info 
6-[(3S,4S)-1-benzyl-4-methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one
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C22H27N5O2
  1
1
IC50 > 1000 nM
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Biochemical Assays
Compound ID Compound Name Compound Formula
CP0189624
 Compound Info 
7,8-dimethoxy-N-[1-(5-methyl-1H-pyrazol-3-yl)propan-2-yl]quinazolin-4-amine
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C17H21N5O2
  1
1 IC50 = 83 nM
Clinical Information about the Protein
Target 1 ( Phosphodiesterase 1C (PDE1C) )
Target Type Literature-reported Target