General Information of the Protein
| Protein ID |
PT02002
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| Protein Name |
Gamma-aminobutyric acid receptor subunit alpha-5
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| Secondarily Protein Name |
GABA(A) receptor subunit alpha-5
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| Gene Name |
GABRA5
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| Sequence |
MDNGMFSGFIMIKNLLLFCISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAAKIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESKKTYNSISKIDKMSRIVFPVLFGTFNLVYWATYLNREPVIKGAASPK
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| Organism |
Homo sapiens, Human
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| Protein Classification |
Ion channel
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Ligand-gated ion channel
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GABA-A receptor
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| Function |
Ligand-gated chloride channel subunit which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:29961870, PubMed:31056671). May be involved in GABA-A receptor assembly, and GABA-A receptor immobilization and accumulation by gephyrin at the synapse (PubMed:31056671).
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| Uniprot ID |
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| HGNC ID | |||||
| Subcellular Location |
Postsynaptic cell membrane
Cell membrane
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
Cell Line ID: CL000013 , Sf9
Biochemical Assays
| Compound ID | Compound Name | Compound Formula | |
| CP0000163 |
Ambien
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C19H21N3O
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1 |
| 1 | EC50 > 3000 nM | ||
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| CP0000619 |
RO-154513
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C15H14N6O3
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1 |
| 1 | Kd = 3.8 nM | ||
Clinical Information about the Protein
Target 1 ( GABA(A) receptor alpha-5 (GABRA5) )
| Target Type | Successful Target | ||||
|---|---|---|---|---|---|
| Disease | 4 Target-related Diseases | 4 | |||
| 1 | Benzodiazepine overdose [ICD-11: PC91] | ||||
| 2 | Alzheimer disease [ICD-11: 8A20] | ||||
| 3 | Inflammatory bowel disease [ICD-11: DD72] | ||||
| 4 | Inflammation [ICD-11: 1A00-CA43.1] | ||||
| Approved Drug(s) | 1 Approved Drug | 1 | |||
| 1 | Flumazenil | Approved | |||
| Clinical Trial Drug(s) | 2 Clinical Trial Drugs | 2 | |||
| 1 | Basmisanil | Phase 2 | |||
| 2 | GSK683699 | Phase 2 | |||
| Investigative Drug(s) | 1 Investigative Drug | 1 | |||
| 1 | [3H]CGS8216 | Investigative | |||
Similar Protein(s) and Bioactivity Statistics
50% Identity
| Protein ID | Protein Name | Protein Organism | |
| PT03373 | Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens, Human | |
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