General Information of the Protein
Protein ID
PT01861
Protein Name
Urokinase plasminogen activator surface receptor
Secondarily
Protein Name
Monocyte activation antigen Mo3
Gene Name
PLAUR
Secondarily
Gene Name
MO3
UPAR
Sequence
MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDVQYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
Function
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
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Uniprot ID
Primary ID:
Q03405

Secondarily ID:
A8K409
Q12876
Q15845
Q16887
Q6IB52
Q9BWT0
Q9NYC8
Q9UD69
Q9UEA6
Q9UM92
Q9UMV0
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Ensembl ID
ENSG00000011422
HGNC ID
HGNC:9053
Subcellular Location
Cell membrane
Cell projection
Invadopodium membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000090 , Schneider 2
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0262048
 Compound Info 
morpholin-4-yl-(2-phenyl-8-thiophen-2-ylquinolin-4-yl)methanone
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C24H20N2O2S
  3
1
IC50 = 500 nM
 Bioactivity Info 
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2
IC50 = 4900 nM
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3
IC50 = 8600 nM
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CP0484996
 Compound Info 
[2-(3-fluorophenyl)-8-thiophen-2-ylquinolin-4-yl]-morpholin-4-ylmethanone
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C24H19FN2O2S
  2
1
IC50 = 500 nM
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2
IC50 = 7500 nM
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CP0419776
 Compound Info 
[2-(4-methoxyphenyl)-8-thiophen-2-ylquinolin-4-yl]-morpholin-4-ylmethanone
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C25H22N2O3S
  2
1
IC50 = 2200 nM
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2
IC50 = 12300 nM
 Bioactivity Info 
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CP0557980
 Compound Info 
[2-(3-methoxyphenyl)-8-thiophen-2-ylquinolin-4-yl]-morpholin-4-ylmethanone
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C25H22N2O3S
  2
1
IC50 = 2200 nM
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2
IC50 = 12000 nM
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CP0484993
 Compound Info 
morpholin-4-yl-[2-phenyl-8-(1,3-thiazol-5-yl)quinolin-4-yl]methanone
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C23H19N3O2S
  2
1
IC50 = 5800 nM
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2
IC50 = 80500 nM
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CP0484673
 Compound Info 
morpholin-4-yl-[2-phenyl-8-(2-phenylethyl)quinolin-4-yl]methanone
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C28H26N2O2
  1
1
IC50 = 6200 nM
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CP0423444
 Compound Info 
morpholin-4-yl-[2-phenyl-8-(2-phenylethynyl)quinolin-4-yl]methanone
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C28H22N2O2
  2
1
IC50 = 8500 nM
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2
IC50 = 50000 nM
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CP0471163
 Compound Info 
morpholin-4-yl-(2-pyridin-3-yl-8-thiophen-2-ylquinolin-4-yl)methanone
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C23H19N3O2S
  2
1
IC50 = 8500 nM
 Bioactivity Info 
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2
IC50 = 22700 nM
 Bioactivity Info 
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CP0423438
 Compound Info 
morpholin-4-yl-(2-phenyl-8-thiophen-2-yl-1,6-naphthyridin-4-yl)methanone
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C23H19N3O2S
  3
1
IC50 = 9300 nM
 Bioactivity Info 
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2
IC50 = 10400 nM
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3
Kd = 13000 nM
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CP0419811
 Compound Info 
2-phenyl-4-(1-piperidin-4-ylpyrazol-3-yl)-8-thiophen-2-ylquinoline
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C27H24N4S
  1
1
IC50 = 9500 nM
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CP0531561
 Compound Info 
(2,8-diphenylquinolin-4-yl)-morpholin-4-ylmethanone
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C26H22N2O2
  2
1
IC50 = 9800 nM
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2
IC50 = 13900 nM
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CP0419810
 Compound Info 
(2-phenyl-8-thiophen-2-ylquinolin-4-yl)-piperazin-1-ylmethanone
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C24H21N3OS
  1
1
IC50 = 13100 nM
 Bioactivity Info 
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CP0423738
 Compound Info 
[4-(3-chlorophenyl)piperazin-1-yl]-(2-phenyl-8-thiophen-2-ylquinolin-4-yl)methanone
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C30H24ClN3OS
  1
1
IC50 = 13400 nM
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CP0479973
 Compound Info 
2-[4-(morpholine-4-carbonyl)-2-phenylquinolin-8-yl]isoindole-1,3-dione
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C28H21N3O4
  2
1
IC50 = 25000 nM
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2
IC50 = 73800 nM
 Bioactivity Info 
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CP0498450
 Compound Info 
(8-methyl-2-phenylquinolin-4-yl)-morpholin-4-ylmethanone
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C21H20N2O2
  2
1
IC50 = 89700 nM
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2
IC50 = 141000 nM
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Clinical Information about the Protein
Target 1 ( Urokinase plasminogen activator surface receptor (PLAUR) )
Target Type Successful Target
Disease 1 Target-related Disease  1
1 High-risk myelofibrosis [ICD-11: 2A20.2]
Approved Drug(s) 1 Approved Drug  1
1 Ruxolitinib
 Drug Info 
Approved
High-risk myelofibrosis
Target 2 ( Urokinase plasminogen receptor (PLAUR) )
Target Type Literature-reported Target