General Information of the Protein
| Protein ID |
PT01851
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| Protein Name |
Farnesyl pyrophosphate synthase
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| Secondarily Protein Name |
(2E,6E)-farnesyl diphosphate synthase
Dimethylallyltranstransferase
Farnesyl diphosphate synthase
Geranyltranstransferase
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| Gene Name |
FDPS
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| Secondarily Gene Name |
FPS
KIAA1293
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| Sequence |
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
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| Organism |
Homo sapiens, Human
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| Protein Classification |
Enzyme
>
Transferase
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| Function |
Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
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| Uniprot ID |
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| Ensembl ID | |||||
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| Subcellular Location |
Cytoplasm
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Clinical Information about the Protein
Target 1 ( Geranyltranstransferase (FDPS) )
| Target Type | Successful Target | ||||
|---|---|---|---|---|---|
| Disease | 5 Target-related Diseases | 5 | |||
| 1 | Paget's disease [ICD-11: FB85] | ||||
| 2 | Osteoporosis [ICD-11: FB83.0] | ||||
| 3 | Bone disease [ICD-11: FC0Z] | ||||
| 4 | Hypercalcaemia [ICD-11: 5B91.0] | ||||
| 5 | Acute myeloid leukaemia [ICD-11: 2A60] | ||||
| Approved Drug(s) | 7 Approved Drugs | 7 | |||
| 1 | Alendronate | Approved | |||
| 2 | Ibandronate | Approved | |||
| 3 | Minodronate | Approved | |||
| 4 | NERIDRONIC ACID | Approved | |||
| 5 | Pamidronate | Approved | |||
| 6 | Risedronate | Approved | |||
| 7 | Zoledronate | Approved | |||
| Clinical Trial Drug(s) | 1 Clinical Trial Drug | 1 | |||
| 1 | Zarnestra | Phase 3 | |||