General Information of the Protein
Protein ID
PT01847
Protein Name
Suppressor of tumorigenicity 14 protein
Secondarily
Protein Name
Matriptase
Membrane-type serine protease 1
Prostamin
Serine protease 14
Serine protease TADG-15
Tumor-associated differentially-expressed gene 15 protein
Gene Name
ST14
Secondarily
Gene Name
PRSS14
SNC19
TADG15
Sequence
MGSDRARKGGGGPKDFGAGLKYNSRHEKVNGLEEGVEFLPVNNVKKVEKHGPGRWVVLAAVLIGLLLVLLGIGFLVWHLQYRDVRVQKVFNGYMRITNENFVDAYENSNSTEFVSLASKVKDALKLLYSGVPFLGPYHKESAVTAFSEGSVIAYYWSEFSIPQHLVEEAERVMAEERVVMLPPRARSLKSFVVTSVVAFPTDSKTVQRTQDNSCSFGLHARGVELMRFTTPGFPDSPYPAHARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHALVQLCGTYPPSYNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEINGEKYCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWIKENTGV
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Protease
>
Serine protease
>
Serine protease PA clan
>
Serine protease S1A subfamily
Function
Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (PubMed:10373424). Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing (PubMed:18843291). Proteolytically cleaves and therefore activates TMPRSS13 (PubMed:28710277).
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Uniprot ID
Primary ID:
Q9Y5Y6

Secondarily ID:
Q9BS01
Q9H3S0
Q9HB36
Q9HCA3
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Ensembl ID
ENSG00000149418
HGNC ID
HGNC:11344
Subcellular Location
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0807142
 Compound Info 
Benzylsulfonyl-D-argininyl-proline-(4-amidinobenzyl)amide Bis-(trifluoroacetate)
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C28H37F3N8O6S
  1
1
Ki = 55 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0754265
 Compound Info 
Benzylsulfonyl-D-arginyl-proline-(2-aminomethyl-5-chlorobenzyl)-amide Bis(trifluoroacetate)
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C28H37ClF3N7O6S
  1
1
Ki = 220 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0704349
 Compound Info 
Benzylsulfonyl-D-cyclohexylalanyl-proline-(4-amidinobenzyl)-amide Trifluoroacetate
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C31H40F3N5O6S
  1
1
Ki = 770 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0038011
 Compound Info 
CHEBI:6426
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C20H38N6O4
  1
1
Ki = 1900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0844406
 Compound Info 
Benzylsulfonyl-D-cyclohexylalanyl-proline-(2-aminomethyl-5-chlorobenzyl)amide Trifluoroacetate
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C31H40ClF3N4O6S
  1
1
Ki = 2100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000090 , Schneider 2
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0322602
 Compound Info 
US10988505, Comparative #2
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C21H30N8O4S
  1
1 Ki = 0.088 nM
CP0038011
 Compound Info 
CHEBI:6426
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C20H38N6O4
  1
1 Ki = 696 nM
CP0106538
 Compound Info 
US9365853, 2
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C27H44N12O5S
  1
1 Ki = 6124 nM
Clinical Information about the Protein
Target 1 ( Suppressor of tumorigenicity 14 protein (ST14) )
Target Type Patented-recorded Target