General Information of the Protein
| Protein ID |
PT01760
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| Protein Name |
Interleukin-1 receptor type 1
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| Secondarily Protein Name |
CD121 antigen-like family member A
Interleukin-1 receptor alpha
Interleukin-1 receptor type I
p80
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| Gene Name |
IL1R1
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| Secondarily Gene Name |
IL1R
IL1RA
IL1RT1
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| Sequence |
MKVLLRLICFIALLISSLEADKCKEREEKIILVSSANEIDVRPCPLNPNEHKGTITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHGIDAAYIQLIYPVTNFQKHMIGICVTLTVIIVCSVFIYKIFKIDIVLWYRDSCYDFLPIKASDGKTYDAYILYPKTVGEGSTSDCDIFVFKVLPEVLEKQCGYKLFIYGRDDYVGEDIVEVINENVKKSRRLIIILVRETSGFSWLGGSSEEQIAMYNALVQDGIKVVLLELEKIQDYEKMPESIKFIKQKHGAIRWSGDFTQGPQSAKTRFWKNVRYHMPVQRRSPSSKHQLLSPATKEKLQREAHVPLG
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| Organism |
Homo sapiens, Human
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| Protein Classification |
Membrane receptor
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| Function |
Receptor for IL1A, IL1B and IL1RN (PubMed:2950091). After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850).
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| Uniprot ID |
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| Ensembl ID | |||||
| HGNC ID | |||||
| Subcellular Location |
Membrane
Cell membrane
Secreted
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000870 , HEK-Blue Null1-v
| Compound ID | Compound Name | Compound Formula | |
| CP0001611 |
2-(2,4-dichlorophenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide
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C16H10Cl2N4O2S
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1 |
| 1 |
IC50 = 720 nM
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TI
LI
LO
TS
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Cell Line ID: CL000752 , PBMC iPSC #1
Clinical Information about the Protein
Target 1 ( Interleukin 1 receptor type 1 (IL1R1) )
| Target Type | Successful Target | ||||
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Target 2 ( HUMAN interleukin-1 receptor 1 (IL1R1) )
| Target Type | Unknown Type Target | ||||
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