General Information of the Protein
Protein ID
PT01607
Protein Name
Sodium-dependent noradrenaline transporter
Secondarily
Protein Name
Norepinephrine transporter
Solute carrier family 6 member 2
Gene Name
SLC6A2
Sequence
MLLARMNPQVQPELGGADPLPEQPLRPCKTADLLVVKERNGVQCLLASQDSDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHSWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCVVTISTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYTYPPWANWVGWGIALSSMILVPAYVIYKFLSIRGSLWERVAYGITPENEHHLVAQRDVRQFQLRHWLAI
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Organism
Mus musculus, Mouse
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC06 neurotransmitter transporter family
Function
Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (PubMed:16269905). Can also mediate sodium- and chloride-dependent transport of dopamine (By similarity).
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Uniprot ID
Primary ID:
O55192

Secondarily ID:
Q6QU62
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Ensembl ID
ENSG00000103546
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000035 , NIH 3T3
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0036757
 Compound Info 
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
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C19H24N2
  1
1
Ki = 16 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0050763
 Compound Info 
1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine
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C21H21N
  1
1
Ki = 290 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0157151
 Compound Info 
9,10-dihydroanthracene(DHA), 1a
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C15H15N
  1
1
Ki > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0036757
 Compound Info 
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
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C19H24N2
  1
1 Ki = 12 nM
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT00034 Transporter Rattus norvegicus, Rat
 Protein Info 
PT01026 Sodium-dependent noradrenaline transporter Homo sapiens, Human
 Protein Info