General Information of the Protein
Protein ID
PT00034
Protein Name
Transporter
Gene Name
NET
Sequence
MLLARMKPQVQPELGGADQLPEQPLRPCKTADLLVVKERNGVQCLLASQDGDAQPRETWGKEIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQFNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAYGITPENEHHLVAQRDVRQFQLRHWLAI
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Organism
Rattus norvegicus, Rat
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC06 neurotransmitter transporter family
Uniprot ID
Q63380
Subcellular Location
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0340079
 Compound Info 
(1R,2R)-2-(aminomethyl)-N,N-bis(prop-2-enyl)-1-thiophen-2-ylcyclopropane-1-carboxamide
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C15H20N2OS
  1
1
IC50 = 4.6 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0415130
 Compound Info 
(1S,2R)-N-allyl-2-(aminomethyl)-N-ethyl-1-(thiophen-3-yl)cyclopropanecarboxamide
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C14H20N2OS
  1
1
IC50 = 6.4 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0439277
 Compound Info 
2-[(1R,2R)-2-(Aminomethyl)-1-(2-thienyl)cyclopropanecarbonyl] isoindoline
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C17H18N2OS
  1
1
IC50 = 15 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0434930
 Compound Info 
1S,2R-milnacipran
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C15H22N2O
  1
1
IC50 = 16 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0139009
 Compound Info 
(1R,2R)-2-(aminomethyl)-N-ethyl-N-(2-fluoroprop-2-enyl)-1-thiophen-2-ylcyclopropane-1-carboxamide
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C14H19FN2OS
  1
1
IC50 = 21 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0037646
 Compound Info 
Midalcipran
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C15H22N2O
  1
1
IC50 = 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0383846
 Compound Info 
(1R,2R)-2-(aminomethyl)-N-ethyl-N-prop-2-ynyl-1-thiophen-2-ylcyclopropane-1-carboxamide
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C14H18N2OS
  1
1
IC50 = 160 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0070614
 Compound Info 
(S)-N-(cyclobutylmethyl)-N-(pyrrolidin-3-yl)-2-(trifluoromethyl)benzamide
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C17H21F3N2O
  1
1
Ki = 3.9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT01026 Sodium-dependent noradrenaline transporter Homo sapiens, Human
 Protein Info 
PT01607 Sodium-dependent noradrenaline transporter Mus musculus, Mouse
 Protein Info