General Information of the Protein
Protein ID
PT01563
Protein Name
Calcium/calmodulin-dependent protein kinase kinase 2
Secondarily
Protein Name
Calcium/calmodulin-dependent protein kinase kinase beta
Gene Name
CAMKK2
Secondarily
Gene Name
CAMKKB
KIAA0787
Sequence
MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEPGCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPSLATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELKEARQRRQPPGHRPAPRGGGGSALVRGSPCVESCWAPAPGSPARMHPLRPEEAMEPE
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
Other protein kinase group
>
Other protein kinase CAMKK family
>
Other protein kinase Meta subfamily
Function
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.
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Uniprot ID
Primary ID:
Q96RR4

Secondarily ID:
A8K7Q7
O94883
Q8IUG2
Q8IUG3
Q8N3I4
Q8WY03
Q8WY04
Q8WY05
Q8WY06
Q96RP1
Q96RP2
Q96RR3
Q9BWE9
Q9UER3
Q9UES2
Q9Y5N2
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Ensembl ID
ENSG00000110931
HGNC ID
HGNC:1470
Subcellular Location
Nucleus
Cytoplasm
Cell projection
Neuron projection
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0138857
 Compound Info 
2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid
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C25H22N2O2
  1
1
IC50 < 3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0138918
 Compound Info 
4-(2-anilinopyrimidin-4-yl)-2-cyclopentylbenzoic acid
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C22H21N3O2
  1
1
IC50 < 3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0138821
 Compound Info 
2-cyclopentyl-4-(2-phenyl-1H-imidazo[4,5-b]pyridin-7-yl)benzoic acid
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C24H21N3O2
  1
1
IC50 = 8.1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0138917
 Compound Info 
2-cyclopentyl-4-quinolin-4-ylbenzoic acid
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C21H19NO2
  1
1
IC50 = 140 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0130566
 Compound Info 
2-cyclopentyl-4-thieno[3,2-d]pyrimidin-4-ylbenzoic acid
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C18H16N2O2S
  1
1
IC50 = 170 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0559107
 Compound Info 
2-cyclopentyl-4-(5-phenylpyrazolo[1,5-a]pyrimidin-3-yl)benzoic acid
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C24H21N3O2
  1
1
IC50 = 190 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0138972
 Compound Info 
2-cyclopentyl-4-pyrazolo[1,5-a]pyridin-3-ylbenzoic acid
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C19H18N2O2
  1
1
IC50 = 200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0317812
 Compound Info 
2-cyclopentyl-4-(5-phenylthieno[2,3-b]pyridin-3-yl)benzoic acid
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C25H21NO2S
  1
1
IC50 = 210 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0313067
 Compound Info 
2-cyclopentyl-4-(1-methyl-2-phenylpyrrolo[2,3-b]pyridin-4-yl)benzoic acid
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C26H24N2O2
  1
1
IC50 = 240 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0138862
 Compound Info 
2-cyclopentyl-4-pyrimidin-4-ylbenzoic acid
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C16H16N2O2
  1
1
IC50 = 290 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0176620
 Compound Info 
2-cyclopentyl-4-(1-methylpyrrolo[2,3-b]pyridin-4-yl)benzoic acid
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C20H20N2O2
  1
1
IC50 = 470 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0176619
 Compound Info 
2-cyclopentyl-4-(5-phenylpyrazolo[1,5-a]pyridin-3-yl)benzoic acid
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C25H22N2O2
  1
1
IC50 = 530 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0138861
 Compound Info 
2-cyclopentyl-4-(6-phenylquinolin-4-yl)benzoic acid
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C27H23NO2
  1
1
IC50 = 540 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0138819
 Compound Info 
2-cyclopentyl-4-(5-phenylfuro[2,3-b]pyridin-3-yl)benzoic acid
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C25H21NO3
  1
1
IC50 = 700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0313063
 Compound Info 
2-cyclopentyl-4-(6-phenylquinazolin-4-yl)benzoic acid
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C26H22N2O2
  1
1
IC50 = 890 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0561694
 Compound Info 
4-(2-aminopyrimidin-4-yl)-2-cyclopentylbenzoic acid
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C16H17N3O2
  1
1
IC50 = 950 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0138860
 Compound Info 
2-cyclopentyl-4-thieno[2,3-d]pyrimidin-4-ylbenzoic acid
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C18H16N2O2S
  1
1
IC50 = 1400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0138969
 Compound Info 
2-cyclopentyl-4-quinazolin-4-ylbenzoic acid
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C20H18N2O2
  1
1
IC50 = 1900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000538 , LNCaP C4-2
 Cell Line Info 
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0138857
 Compound Info 
2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid
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C25H22N2O2
  2
1 IC50 = 3 nM
2 IC50 = 7.943 nM
CP0317812
 Compound Info 
2-cyclopentyl-4-(5-phenylthieno[2,3-b]pyridin-3-yl)benzoic acid
   Show/Hide
C25H21NO2S
  1
1 IC50 = 5 nM
CP0313063
 Compound Info 
2-cyclopentyl-4-(6-phenylquinazolin-4-yl)benzoic acid
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C26H22N2O2
  1
1 IC50 = 12 nM
CP0138917
 Compound Info 
2-cyclopentyl-4-quinolin-4-ylbenzoic acid
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C21H19NO2
  1
1 IC50 = 13 nM
CP0138862
 Compound Info 
2-cyclopentyl-4-pyrimidin-4-ylbenzoic acid
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C16H16N2O2
  1
1 IC50 = 21 nM
CP0559107
 Compound Info 
2-cyclopentyl-4-(5-phenylpyrazolo[1,5-a]pyrimidin-3-yl)benzoic acid
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C24H21N3O2
  1
1 IC50 = 21 nM
CP0138821
 Compound Info 
2-cyclopentyl-4-(2-phenyl-1H-imidazo[4,5-b]pyridin-7-yl)benzoic acid
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C24H21N3O2
  1
1 IC50 = 23 nM
CP0130566
 Compound Info 
2-cyclopentyl-4-thieno[3,2-d]pyrimidin-4-ylbenzoic acid
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C18H16N2O2S
  1
1 IC50 = 24 nM
CP0138863
 Compound Info 
2-cyclopentyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid
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C19H18N2O2
  2
1 IC50 = 26 nM
2 IC50 = 31.62 nM
CP0138860
 Compound Info 
2-cyclopentyl-4-thieno[2,3-d]pyrimidin-4-ylbenzoic acid
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C18H16N2O2S
  1
1 IC50 = 31 nM
CP0138972
 Compound Info 
2-cyclopentyl-4-pyrazolo[1,5-a]pyridin-3-ylbenzoic acid
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C19H18N2O2
  1
1 IC50 = 44 nM
CP0138918
 Compound Info 
4-(2-anilinopyrimidin-4-yl)-2-cyclopentylbenzoic acid
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C22H21N3O2
  1
1 IC50 = 51 nM
CP0176620
 Compound Info 
2-cyclopentyl-4-(1-methylpyrrolo[2,3-b]pyridin-4-yl)benzoic acid
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C20H20N2O2
  1
1 IC50 = 56 nM
CP0138819
 Compound Info 
2-cyclopentyl-4-(5-phenylfuro[2,3-b]pyridin-3-yl)benzoic acid
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C25H21NO3
  1
1 IC50 = 65 nM
CP0138969
 Compound Info 
2-cyclopentyl-4-quinazolin-4-ylbenzoic acid
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C20H18N2O2
  1
1 IC50 = 96 nM
CP0561694
 Compound Info 
4-(2-aminopyrimidin-4-yl)-2-cyclopentylbenzoic acid
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C16H17N3O2
  1
1 IC50 = 108 nM
CP0313067
 Compound Info 
2-cyclopentyl-4-(1-methyl-2-phenylpyrrolo[2,3-b]pyridin-4-yl)benzoic acid
   Show/Hide
C26H24N2O2
  1
1 IC50 = 120 nM
CP0138861
 Compound Info 
2-cyclopentyl-4-(6-phenylquinolin-4-yl)benzoic acid
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C27H23NO2
  1
1 IC50 = 137 nM
CP0176619
 Compound Info 
2-cyclopentyl-4-(5-phenylpyrazolo[1,5-a]pyridin-3-yl)benzoic acid
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C25H22N2O2
  1
1 IC50 = 145 nM
Clinical Information about the Protein
Target 1 ( Calmodulin-dependent kinase II (CAMKK2) )
Target Type Patented-recorded Target