Protein Information

General Information of the Protein

Protein ID	PT01553
Protein Name	Type-2 angiotensin II receptor
Secondarily Protein Name	Angiotensin II type-2 receptor
Gene Name	AGTR2
Sequence	MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Peptide receptor (family A GPCR) > Short peptide receptor (family A GPCR) > Angiotensin receptor
Function	Receptor for angiotensin II, a vasoconstricting peptide (PubMed:8185599, PubMed:28379944, PubMed:29967536, PubMed:31899086). Signals primarily via a non-canonical G-protein- and beta-arrestin independent pathways (PubMed:28379944). Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation (PubMed:15123706). Show/Hide
Uniprot ID	Primary ID: P50052 Secondarily ID: B2R9V1 Q13016 Q6FGY7 Show/Hide
HGNC ID	HGNC:338
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0140080 Compound Info	2-[4-[[2-ethoxy-4-ethyl-5-[[[(2S)-4-methyl-2-sulfanylpentanoyl]amino]methyl]imidazol-1-yl]methyl]-3-fluorophenyl]benzoic acid Show/Hide	C28H34FN3O4S	1
1	Ki = 2511.89 nM Bioactivity Info	TI LI LO TS
CP0041674 Compound Info	(S)-3-Methyl-2-{pentanoyl-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-butyric acid Show/Hide	C24H29N5O3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0036566 Compound Info	5-L-isoleucineangiotensin II Show/Hide	C50H71N13O12	4
1	IC50 = 2.5 nM
2	Ki = 0.2 nM
3	Ki = 0.23 nM
4	Ki = 1.2 nM
CP0047101 Compound Info	(1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol Show/Hide	C23H29N3O4S2	1
1	Ki = 0.4 nM
CP0083007 Compound Info	butyl N-[3-[3-(imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)thiophen-2-yl]sulfonylcarbamate Show/Hide	C23H29N3O4S2	1
1	Ki = 17.8 nM

Clinical Information about the Protein

Target 1 ( Angiotensin II receptor type-2 (AGTR2) )

Target Type	Successful Target
Disease	3 Target-related Diseases				3
1	Increase blood pressure [ICD-11: BA04]
2	Hypertension [ICD-11: BA00-BA04]
3	Postherpetic neuralgia [ICD-11: 1E91.5]
Approved Drug(s)	2 Approved Drugs				2
1	ANGIOTENSIN II	Drug Info	Approved	Increase blood pressure
2	SARALASIN	Drug Info	Approved	Hypertension
Clinical Trial Drug(s)	1 Clinical Trial Drug				1
1	EMA-401	Drug Info	Phase 2	Postherpetic neuralgia
Discontinued Drug(s)	2 Discontinued Drugs				2
1	L-158809	Drug Info	Terminated	Hypertension
2	L-159689	Drug Info	Terminated	Hypertension