General Information of the Protein
Protein ID
PT01498
Protein Name
17-beta-hydroxysteroid dehydrogenase type 1
Secondarily
Protein Name
20 alpha-hydroxysteroid dehydrogenase
E2DH
Estradiol 17-beta-dehydrogenase 1
Placental 17-beta-hydroxysteroid dehydrogenase
Short chain dehydrogenase/reductase family 28C member 1
Gene Name
HSD17B1
Secondarily
Gene Name
E17KSR
EDH17B1
EDH17B2
EDHB17
SDR28C1
Sequence
MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGGGAGPGAEDEAGRGAVGDPELGDPPAAPQ
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Oxidoreductase
Function
Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:8994190). Also has 20-alpha-HSD activity. Uses preferentially NADH.
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Uniprot ID
Primary ID:
P14061

Secondarily ID:
B3KXS1
Q2M2L8
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Ensembl ID
ENSG00000108786
HGNC ID
HGNC:5210
Subcellular Location
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0382026
 Compound Info 
((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methyl 9-((8R,9S,13S,14S,16S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-16-yl)nonanoate
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C37H51N5O7
  1
1
IC50 = 52 nM
 Bioactivity Info 
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CP0485824
 Compound Info 
5'-O-{11-[3',17'beta-dihydroxy-1',3',5'(10')-estratrien-16'alpha/beta-yl]-undecanoyl} adenosine
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C39H55N5O7
  1
1
IC50 = 90 nM
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CP0453411
 Compound Info 
((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl 7-((8R,9S,13S,14S,16S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-16-yl)heptanoate
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C36H49N5O7
  1
1
IC50 = 93 nM
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CP0399754
 Compound Info 
((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl 11-((8R,9S,13S,14S,16S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-16-yl)undecanoate
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C39H55N5O7
  1
1
IC50 = 120 nM
 Bioactivity Info 
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CP0502151
 Compound Info 
((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl 10-((8R,9S,13S,14S,16S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-16-yl)decanoate
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C38H53N5O7
  1
1
IC50 = 140 nM
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CP0378223
 Compound Info 
((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl 11-((8R,9S,13S,14S,16R,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-16-yl)undecanoate
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C39H55N5O7
  1
1
IC50 = 310 nM
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CP0521540
 Compound Info 
((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl 8-((8R,9S,13S,14S,16S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-16-yl)octanoate
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C35H47N5O7
  1
1
IC50 = 430 nM
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CP0419561
 Compound Info 
((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl 12-((8R,9S,13S,14S,16S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-16-yl)dodecanoate
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C40H57N5O7
  1
1
IC50 = 1000 nM
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CP0485822
 Compound Info 
5'-O-{6-[3',17'beta-dihydroxy-1',3',5'(10')-estratrien-16'alpha/beta-yl]-hexanoyl} adenosine
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C34H45N5O7
  1
1
IC50 = 6900 nM
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CP0453410
 Compound Info 
5'-O-{3-[3',17'beta-dihydroxy-1',3',5'(10')-estratrien-16'alpha-yl]-propanoyl} adenosine
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C31H39N5O7
  1
1
IC50 = 13500 nM
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CP0378933
 Compound Info 
(2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-acetoxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid
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C32H48O5
  1
1
IC50 = 18800 nM
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CP0455097
 Compound Info 
N-[2-(3,4-dimethoxyphenyl)ethyl]-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide
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C21H27NO5
  1
1
IC50 = 20200 nM
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CP0433445
 Compound Info 
(R)-2-((2S,4aR,6S,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-hydroxy-2,4a,6,6a,6b,9,9,12a,14b-nonamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxamido)-3-phenylpropanoic acid
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C41H59NO5
  1
1
IC50 > 30000 nM
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CP0433446
 Compound Info 
(2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-amino-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid
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C30H47NO3
  1
1
IC50 > 30000 nM
 Bioactivity Info 
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CP0897971
 Compound Info 
4-(2,4-dichlorophenyl)-2-hydroxy-3-(4-methoxy-3-methylbenzoyl)-5-(2-methoxyethyl)cyclopent-2-enone
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C23H22Cl2O5
  1
1
IC50 > 30000 nM
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Cell Line ID: CL000078 , T-47D
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0210432
 Compound Info 
[5-(4-hydroxy-3-methylphenyl)thiophen-2-yl]-(3-hydroxyphenyl)methanone
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C18H14O3S
  1
1 IC50 = 8 nM
CP0259627
 Compound Info 
(8R,9S,13S,14S,16R,17S)-16-(3-bromopropyl)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
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C21H29BrO2
  1
1 IC50 = 460 nM
CP0044042
 Compound Info 
(1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-trien-14-one
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C18H22O2
  3
1 Ki = 3 nM
2 Ki = 9500 nM
3 Km = 4600 nM
Clinical Information about the Protein
Target 1 ( Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) )
Target Type Clinical trial Target