General Information of the Protein
Protein ID
PT01406
Protein Name
Nitric oxide synthase 1
Secondarily
Protein Name
Constitutive NOS
NC-NOS
NOS type I
Neuronal NOS
Nitric oxide synthase
brain
Peptidyl-cysteine S-nitrosylase NOS1
Gene Name
NOS1
Sequence
MEDHMFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQPLGPPTKAVDLSHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLAPRPPGQDPAKKATRVSLQGRGENNELLKEIEPVLSLLTSGSRGVKGGAPAKAEMKDMGIQVDRDLDGKSHKPLPLGVENDRVFNDLWGKGNVPVVLNNPYSEKEQPPTSGKQSPTKNGSPSKCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHPSQHARRPEDVRTKGQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPELTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRIQADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSAEDAGVFISRMRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDEVFSS
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
Function
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.
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Uniprot ID
Primary ID:
P29475

Secondarily ID:
E9PH30
O75713
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Ensembl ID
ENSG00000089250
HGNC ID
HGNC:7872
Subcellular Location
Cell membrane
Sarcolemma
Cell projection
Dendritic spine
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0093086
 Compound Info 
quinolinone, 42
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C21H15ClF2N4O2
  1
1
EC50 = 70 nM
 Bioactivity Info 
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CP0398434
 Compound Info 
quinolinone, 43
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C22H16ClF2N3O3
  1
1
EC50 = 97 nM
 Bioactivity Info 
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CP0270646
 Compound Info 
quinolinone, 40
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C21H14ClF2N3O2S
  1
1
EC50 = 120 nM
 Bioactivity Info 
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CP0676149
 Compound Info 
N-(3-Chlorophenyl)-N-((7,8-difluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)-4-methylnicotinamide
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C23H20ClF2N3O2
  1
1
EC50 = 290 nM
 Bioactivity Info 
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CP0073970
 Compound Info 
4-[(2-cyclobutylimidazo[4,5-b]pyrazin-3-yl)methyl]-7,8-difluoro-1H-quinolin-2-one
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C19H15F2N5O
  1
1
EC50 = 300 nM
 Bioactivity Info 
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CP0074303
 Compound Info 
7,8-difluoro-4-[[2-(2-methylpropyl)imidazo[4,5-b]pyrazin-3-yl]methyl]-1H-quinolin-2-one
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C19H17F2N5O
  1
1
EC50 = 300 nM
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CP0382517
 Compound Info 
N-(1,3-benzodioxol-5-ylmethyl)-N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N'-(1,3-thiazol-2-ylmethyl)propane-1,3-diamine
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C20H21N7O2S2
  1
1
EC50 = 310 nM
 Bioactivity Info 
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CP0458775
 Compound Info 
4-[(2-cyclobutylbenzimidazol-1-yl)methyl]-7,8-difluoro-1H-quinolin-2-one
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C21H17F2N3O
  1
1
EC50 = 320 nM
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CP0858282
 Compound Info 
N-(3-Chlorophenyl)-N-((8-fluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)-1-methyl-1H-imidazole-5-carboxamide
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C20H14ClFN4O2
  1
1
EC50 = 360 nM
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CP0387927
 Compound Info 
N-(1,3-benzodioxol-5-ylmethyl)-N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N'-(pyridin-3-ylmethyl)propane-1,3-diamine
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C22H23N7O2S
  1
1
EC50 = 480 nM
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CP0389984
 Compound Info 
quinolinone, 24
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C22H17ClFN3O3
  1
1
EC50 = 500 nM
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CP0458756
 Compound Info 
4-[(2-cyclobutylimidazo[4,5-b]pyridin-1-yl)methyl]-7,8-difluoro-1H-quinolin-2-one
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C20H16F2N4O
  1
1
EC50 = 520 nM
 Bioactivity Info 
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CP0489800
 Compound Info 
7,8-difluoro-4-[(2-propan-2-ylimidazo[4,5-b]pyrazin-3-yl)methyl]-1H-quinolin-2-one
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C18H15F2N5O
  1
1
EC50 = 610 nM
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CP0390208
 Compound Info 
4-[[2-(cyclobutylmethyl)benzimidazol-1-yl]methyl]-7,8-difluoro-1H-quinolin-2-one
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C22H19F2N3O
  1
1
EC50 = 650 nM
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CP0503111
 Compound Info 
7,8-difluoro-4-[[2-(3-methylbutyl)benzimidazol-1-yl]methyl]-1H-quinolin-2-one
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C22H21F2N3O
  1
1
EC50 = 650 nM
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CP0503135
 Compound Info 
7,8-difluoro-4-[(2-propan-2-ylbenzimidazol-1-yl)methyl]-1H-quinolin-2-one
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C20H17F2N3O
  1
1
EC50 = 650 nM
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CP0455362
 Compound Info 
7,8-difluoro-4-[[2-(2-methylpropyl)benzimidazol-1-yl]methyl]-1H-quinolin-2-one
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C21H19F2N3O
  1
1
EC50 = 690 nM
 Bioactivity Info 
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CP0458814
 Compound Info 
7,8-difluoro-4-[(2-propylbenzimidazol-1-yl)methyl]-1H-quinolin-2-one
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C20H17F2N3O
  1
1
EC50 = 690 nM
 Bioactivity Info 
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CP0400637
 Compound Info 
N-(1,3-benzodioxol-5-ylmethyl)-N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N'-(thiophen-2-ylmethyl)propane-1,3-diamine
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C21H22N6O2S2
  1
1
EC50 = 690 nM
 Bioactivity Info 
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CP0458813
 Compound Info 
4-[(2-cyclobutylimidazo[4,5-c]pyridin-3-yl)methyl]-7,8-difluoro-1H-quinolin-2-one
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C20H16F2N4O
  1
1
EC50 = 730 nM
 Bioactivity Info 
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CP0459893
 Compound Info 
4-[(7-chloro-2-cyclobutylimidazo[4,5-b]pyridin-3-yl)methyl]-7,8-difluoro-1H-quinolin-2-one
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C20H15ClF2N4O
  1
1
EC50 = 760 nM
 Bioactivity Info 
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CP0503110
 Compound Info 
4-[(2-cyclopentylbenzimidazol-1-yl)methyl]-7,8-difluoro-1H-quinolin-2-one
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C22H19F2N3O
  1
1
EC50 = 770 nM
 Bioactivity Info 
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CP0458772
 Compound Info 
4-[[2-(cyclopropylmethyl)benzimidazol-1-yl]methyl]-7,8-difluoro-1H-quinolin-2-one
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C21H17F2N3O
  1
1
EC50 = 950 nM
 Bioactivity Info 
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CP0458774
 Compound Info 
7,8-difluoro-4-[[2-(3-methylpyridin-4-yl)benzimidazol-1-yl]methyl]-1H-quinolin-2-one
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C23H16F2N4O
  1
1
EC50 = 990 nM
 Bioactivity Info 
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CP0447283
 Compound Info 
4-[[2-cyclobutyl-7-(dimethylamino)imidazo[4,5-b]pyridin-3-yl]methyl]-7,8-difluoro-1H-quinolin-2-one
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C22H21F2N5O
  1
1
EC50 = 1000 nM
 Bioactivity Info 
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CP0501383
 Compound Info 
4-[(2-cyclopentylimidazo[4,5-b]pyrazin-3-yl)methyl]-7,8-difluoro-1H-quinolin-2-one
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C20H17F2N5O
  1
1
EC50 = 1000 nM
 Bioactivity Info 
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CP0447284
 Compound Info 
4-[[2-(3,3-difluorocyclobutyl)imidazo[4,5-b]pyrazin-3-yl]methyl]-7,8-difluoro-1H-quinolin-2-one
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C19H13F4N5O
  1
1
EC50 = 1100 nM
 Bioactivity Info 
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CP0389577
 Compound Info 
4-[(2-cyclobutyl-7-methoxyimidazo[4,5-b]pyridin-3-yl)methyl]-7,8-difluoro-1H-quinolin-2-one
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C21H18F2N4O2
  1
1
EC50 = 1300 nM
 Bioactivity Info 
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CP0458771
 Compound Info 
4-[(2-cyclobutylimidazo[4,5-b]pyridin-3-yl)methyl]-7,8-difluoro-1H-quinolin-2-one
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C20H16F2N4O
  1
1
EC50 = 1300 nM
 Bioactivity Info 
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CP0502916
 Compound Info 
4-[(2-cyclopropylbenzimidazol-1-yl)methyl]-7,8-difluoro-1H-quinolin-2-one
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C20H15F2N3O
  1
1
EC50 = 1400 nM
 Bioactivity Info 
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CP0436568
 Compound Info 
7,8-difluoro-4-[[2-(4-methyl-1,3-thiazol-5-yl)benzimidazol-1-yl]methyl]-1H-quinolin-2-one
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C21H14F2N4OS
  1
1
EC50 = 1500 nM
 Bioactivity Info 
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CP0455363
 Compound Info 
4-[(2-cyclobutyl-7-methylimidazo[4,5-b]pyridin-3-yl)methyl]-7,8-difluoro-1H-quinolin-2-one
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C21H18F2N4O
  1
1
EC50 = 1600 nM
 Bioactivity Info 
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CP0390212
 Compound Info 
4-[[2-cyclobutyl-7-(trifluoromethyl)imidazo[4,5-b]pyridin-3-yl]methyl]-7,8-difluoro-1H-quinolin-2-one
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C21H15F5N4O
  1
1
EC50 = 2000 nM
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CP0398386
 Compound Info 
quinolinone, 20
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C23H17ClFN3O2
  1
1
EC50 = 2100 nM
 Bioactivity Info 
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CP0439972
 Compound Info 
N-(1,3-benzodioxol-5-ylmethyl)-N'-(furan-2-ylmethyl)-N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)propane-1,3-diamine
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C21H22N6O3S
  1
1
EC50 = 2100 nM
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CP0372235
 Compound Info 
quinolinone, 21
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C23H17ClFN3O2
  1
1
EC50 = 2200 nM
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CP0089375
 Compound Info 
quinolinone, 12
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C21H15ClFN3O2S
  1
1
EC50 = 2300 nM
 Bioactivity Info 
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CP0382511
 Compound Info 
N-(1,3-benzodioxol-5-ylmethyl)-N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N'-propylpropane-1,3-diamine
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C19H24N6O2S
  1
1
EC50 = 2300 nM
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CP0372240
 Compound Info 
quinolinone, 15
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C22H15FN4O2S
  1
1
EC50 = 2700 nM
 Bioactivity Info 
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CP0456480
 Compound Info 
N-[2-(1,3-benzodioxol-5-yl)ethyl]-2-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)pyrrolidine-1-carboxamide
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C22H24N6O3
  1
1
EC50 = 2700 nM
 Bioactivity Info 
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CP0093091
 Compound Info 
quinolinone, 26
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C20H18ClFN2O2
  1
1
EC50 = 2900 nM
 Bioactivity Info 
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CP0458812
 Compound Info 
7,8-difluoro-4-[(2-pyridin-4-ylbenzimidazol-1-yl)methyl]-1H-quinolin-2-one
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C22H14F2N4O
  1
1
EC50 = 2900 nM
 Bioactivity Info 
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CP0262614
 Compound Info 
4-[[2-(3,3-difluorocyclobutyl)imidazo[4,5-b]pyrazin-3-yl]methyl]-8-fluoro-1H-quinolin-2-one
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C19H14F3N5O
  1
1
EC50 = 3000 nM
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CP0270645
 Compound Info 
isoquinoline N-oxide, 47
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C21H14ClF2N3O2S
  1
1
EC50 = 3200 nM
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CP0479402
 Compound Info 
quinolinone, 37
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C21H15ClFN3O2S
  1
1
EC50 = 3400 nM
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CP0382506
 Compound Info 
N-(1,3-benzodioxol-5-ylmethyl)-2-[2-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)pyrrolidin-1-yl]-N-methylethanamine
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C23H28N6O2
  1
1
EC50 = 3900 nM
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CP0398385
 Compound Info 
quinolinone, 22
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C23H17ClFN3O2
  1
1
EC50 = 4100 nM
 Bioactivity Info 
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CP0502915
 Compound Info 
8-fluoro-4-[[2-(4-methyl-1,3-thiazol-5-yl)benzimidazol-1-yl]methyl]-1H-quinolin-2-one
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C21H15FN4OS
  1
1
EC50 = 4300 nM
 Bioactivity Info 
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CP0073971
 Compound Info 
4-[(2-cyclobutylimidazo[4,5-b]pyrazin-3-yl)methyl]-8-fluoro-1H-quinolin-2-one
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C19H16FN5O
  1
1
EC50 = 4600 nM
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CP0389576
 Compound Info 
4-[(2-cyclohexylbenzimidazol-1-yl)methyl]-7,8-difluoro-1H-quinolin-2-one
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C23H21F2N3O
  1
1
EC50 = 5000 nM
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CP0393594
 Compound Info 
N'-(1,3-benzodioxol-5-ylmethyl)-N-[1-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)ethyl]-N'-methylethane-1,2-diamine
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C21H26N6O2
  1
1
EC50 = 6000 nM
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CP0382513
 Compound Info 
2-(1,3-benzodioxol-5-ylmethylamino)-1-[2-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)pyrrolidin-1-yl]ethanone
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C22H24N6O3
  1
1
EC50 = 6600 nM
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CP0455364
 Compound Info 
8-fluoro-4-[[2-(2-methylpropyl)imidazo[4,5-b]pyrazin-3-yl]methyl]-1H-quinolin-2-one
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C19H18FN5O
  1
1
EC50 = 6800 nM
 Bioactivity Info 
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CP0394754
 Compound Info 
N-(1,3-benzodioxol-5-ylmethyl)-N'-[[4-(dimethylamino)phenyl]methyl]-N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)propane-1,3-diamine
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C25H29N7O2S
  1
1
EC50 = 6800 nM
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CP0382514
 Compound Info 
2-[3-(1,3-benzodioxol-5-ylmethylamino)propyl-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)amino]acetonitrile
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C18H19N7O2S
  1
1
EC50 = 7200 nM
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CP0387930
 Compound Info 
2-[3-(1,3-benzodioxol-5-ylmethylamino)propyl-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)amino]-N-methylacetamide
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C19H23N7O3S
  1
1
EC50 = 7200 nM
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CP0382512
 Compound Info 
ethyl 2-[3-(1,3-benzodioxol-5-ylmethylamino)propyl-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)amino]acetate
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C20H24N6O4S
  1
1
EC50 = 7600 nM
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CP0439796
 Compound Info 
quinolinone, 19
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C23H17ClFN3O2
  1
1
EC50 = 7900 nM
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CP0440692
 Compound Info 
N-(1,3-benzodioxol-5-ylmethyl)-N'-(1-benzofuran-5-ylmethyl)-N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)propane-1,3-diamine
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C25H24N6O3S
  1
1
EC50 = 7900 nM
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CP0456478
 Compound Info 
N-(1,3-benzodioxol-5-ylmethyl)-2-[2-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)pyrrolidin-1-yl]acetamide
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C22H24N6O3
  1
1
EC50 = 9500 nM
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CP0372236
 Compound Info 
quinolinone, 13
   Show/Hide
C21H15ClFN3O2S
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0372237
 Compound Info 
quinolinone, 38
   Show/Hide
C21H15ClFN3O2S
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0372238
 Compound Info 
quinolinone, 16
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C22H18FN3O2S
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0372239
 Compound Info 
quinolinone, 17
   Show/Hide
C22H18FN3O3S
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0372268
 Compound Info 
quinolinone, 9
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C21H17N3O2S
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0381830
 Compound Info 
quinolinone, 36
   Show/Hide
C21H15Cl2N3O2S
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0389510
 Compound Info 
isoquinoline, 46
   Show/Hide
C21H14ClF2N3OS
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0389985
 Compound Info 
quinolinone, 39
   Show/Hide
C21H15ClFN3O2S
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0399178
 Compound Info 
quinolinone, 7
   Show/Hide
C21H16N2O3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0417360
 Compound Info 
quinolinone, 11
   Show/Hide
C21H15ClFN3O2S
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0417363
 Compound Info 
quinolinone, 35
   Show/Hide
C21H16ClN3O2S
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0434914
 Compound Info 
quinolinone, 10
   Show/Hide
C21H16FN3O2S
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0456118
 Compound Info 
quinolinone, 44
   Show/Hide
C21H14ClF2N3O2S
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0474543
 Compound Info 
quinolinone, 8
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C21H15FN2O3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0455361
 Compound Info 
4-[[2-(cyclopentylmethyl)benzimidazol-1-yl]methyl]-7,8-difluoro-1H-quinolin-2-one
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C23H21F2N3O
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0456213
 Compound Info 
7,8-difluoro-4-[(2-pyridin-3-ylbenzimidazol-1-yl)methyl]-1H-quinolin-2-one
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C22H14F2N4O
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0458811
 Compound Info 
7,8-difluoro-4-[[2-(1,3-thiazol-5-yl)benzimidazol-1-yl]methyl]-1H-quinolin-2-one
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C20H12F2N4OS
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0459892
 Compound Info 
7,8-difluoro-4-[(2-pyridin-2-ylbenzimidazol-1-yl)methyl]-1H-quinolin-2-one
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C22H14F2N4O
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0489766
 Compound Info 
7,8-difluoro-4-[[2-(4-methylpyridin-3-yl)benzimidazol-1-yl]methyl]-1H-quinolin-2-one
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C23H16F2N4O
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0499029
 Compound Info 
7,8-difluoro-4-[[2-(3-methylimidazol-4-yl)benzimidazol-1-yl]methyl]-1H-quinolin-2-one
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C21H15F2N5O
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0501181
 Compound Info 
4-[(2-ethylbenzimidazol-1-yl)methyl]-7,8-difluoro-1H-quinolin-2-one
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C19H15F2N3O
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0417750
 Compound Info 
quinolinone, 25
   Show/Hide
C22H20ClFN2O2
  1
1
EC50 = 10300 nM
 Bioactivity Info 
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CP0387926
 Compound Info 
4-[[3-(1,3-benzodioxol-5-ylmethylamino)propyl-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)amino]methyl]phenol
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C23H24N6O3S
  1
1
EC50 = 11000 nM
 Bioactivity Info 
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CP0439971
 Compound Info 
2-[3-(1,3-benzodioxol-5-ylmethylamino)propyl-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)amino]acetamide
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C18H21N7O3S
  1
1
EC50 = 11000 nM
 Bioactivity Info 
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CP0338436
 Compound Info 
N-(1,3-benzodioxol-5-ylmethyl)-N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N'-methylpropane-1,3-diamine
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C17H20N6O2S
  1
1
EC50 = 17300 nM
 Bioactivity Info 
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CP0387931
 Compound Info 
N-(1,3-benzodioxol-5-ylmethyl)-N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N'-[(1-methylimidazol-4-yl)methyl]propane-1,3-diamine
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C21H24N8O2S
  1
1
EC50 = 18000 nM
 Bioactivity Info 
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CP0505510
 Compound Info 
4-[(2-cyclobutylimidazo[4,5-c]pyridin-1-yl)methyl]-7,8-difluoro-1H-quinolin-2-one
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C20H16F2N4O
  1
1
EC50 = 24000 nM
 Bioactivity Info 
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CP0372515
 Compound Info 
N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N'-methylpropane-1,3-diamine
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C18H22N6O2S
  1
1
EC50 = 24000 nM
 Bioactivity Info 
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CP0400638
 Compound Info 
N-(1,3-benzodioxol-5-ylmethyl)-N'-cyclopropyl-N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)propane-1,3-diamine
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C19H22N6O2S
  1
1
EC50 = 36000 nM
 Bioactivity Info 
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CP0382491
 Compound Info 
N-[2-(1,3-benzodioxol-5-yl)ethyl]-N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N'-methylpropane-1,3-diamine
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C18H22N6O2S
  1
1
EC50 = 47000 nM
 Bioactivity Info 
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CP0455360
 Compound Info 
4-[(2-tert-butylbenzimidazol-1-yl)methyl]-7,8-difluoro-1H-quinolin-2-one
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C21H19F2N3O
  1
1
EC50 > 100000 nM
 Bioactivity Info 
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CP0036225
 Compound Info 
N-benzyl-N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N'-methylpropane-1,3-diamine
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C16H20N6S
  1
1
EC50 > 100000 nM
 Bioactivity Info 
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CP0372516
 Compound Info 
N-[(3,4-difluorophenyl)methyl]-N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N'-methylpropane-1,3-diamine
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C16H18F2N6S
  1
1
EC50 > 100000 nM
 Bioactivity Info 
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CP0372518
 Compound Info 
N-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N'-methylpropane-1,3-diamine
   Show/Hide
C17H18F2N6O2S
  1
1
EC50 > 100000 nM
 Bioactivity Info 
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CP0382488
 Compound Info 
N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N-(1H-indol-5-ylmethyl)-N'-methylpropane-1,3-diamine
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C18H21N7S
  1
1
EC50 > 100000 nM
 Bioactivity Info 
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CP0382504
 Compound Info 
N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N'-methyl-N-(pyridin-4-ylmethyl)propane-1,3-diamine
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C15H19N7S
  1
1
EC50 > 100000 nM
 Bioactivity Info 
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CP0382505
 Compound Info 
N-(1,3-benzodioxol-5-ylmethyl)-N'-[2-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)propan-2-yl]ethane-1,2-diamine
   Show/Hide
C21H26N6O2
  1
1
EC50 > 100000 nM
 Bioactivity Info 
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CP0382507
 Compound Info 
1-[2-(1,3-benzodioxol-5-yl)ethyl]-3-[(2-imidazol-1-yl-6-methylpyrimidin-4-yl)methyl]urea
   Show/Hide
C19H20N6O3
  1
1
EC50 > 100000 nM
 Bioactivity Info 
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CP0382508
 Compound Info 
2-[3-(1,3-benzodioxol-5-ylmethylamino)propyl-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)amino]acetic acid
   Show/Hide
C18H20N6O4S
  1
1
EC50 > 100000 nM
 Bioactivity Info 
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CP0382515
 Compound Info 
2-[3-(1,3-benzodioxol-5-ylmethylamino)propyl-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)amino]-N,N-dimethylacetamide
   Show/Hide
C20H25N7O3S
  1
1
EC50 > 100000 nM
 Bioactivity Info 
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CP0382516
 Compound Info 
N-(1,3-benzodioxol-5-ylmethyl)-N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N'-(2H-tetrazol-5-ylmethyl)propane-1,3-diamine
   Show/Hide
C18H20N10O2S
  1
1
EC50 > 100000 nM
 Bioactivity Info 
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CP0387928
 Compound Info 
N-(1,3-benzodioxol-5-ylmethyl)-4-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)butan-1-amine
   Show/Hide
C20H23N5O2
  1
1
EC50 > 100000 nM
 Bioactivity Info 
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CP0387932
 Compound Info 
N-(1,3-benzodioxol-5-ylmethyl)-2-[2-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)pyrrol-1-yl]-N-methylethanamine
   Show/Hide
C23H24N6O2
  1
1
EC50 > 100000 nM
 Bioactivity Info 
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CP0387934
 Compound Info 
N-[2-[1,3-benzodioxol-5-ylmethyl(methyl)amino]ethyl]-2-imidazol-1-yl-6-methylpyrimidine-4-carboxamide
   Show/Hide
C20H22N6O3
  1
1
EC50 > 100000 nM
 Bioactivity Info 
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CP0390807
 Compound Info 
N-[2-(1,3-benzodioxol-5-ylmethoxy)ethyl]-1-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)ethanamine
   Show/Hide
C20H23N5O3
  1
1
EC50 > 100000 nM
 Bioactivity Info 
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CP0390832
 Compound Info 
N-[3-[(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-methylamino]propyl]-1,3-benzodioxole-5-carboxamide
   Show/Hide
C17H18N6O3S
  1
1
EC50 > 100000 nM
 Bioactivity Info 
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CP0427668
 Compound Info 
N-[(3,4-dimethoxyphenyl)methyl]-N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N'-methylpropane-1,3-diamine
   Show/Hide
C18H24N6O2S
  1
1
EC50 > 100000 nM
 Bioactivity Info 
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CP0439970
 Compound Info 
N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N-[(4-methoxyphenyl)methyl]-N'-methylpropane-1,3-diamine
   Show/Hide
C17H22N6OS
  1
1
EC50 > 100000 nM
 Bioactivity Info 
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CP0461891
 Compound Info 
2-(1,3-benzodioxol-5-ylmethylamino)-N-[(2-imidazol-1-yl-6-methylpyrimidin-4-yl)methyl]acetamide
   Show/Hide
C19H20N6O3
  1
1
EC50 > 100000 nM
 Bioactivity Info 
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CP0238322
 Compound Info 
4-[(3-chloro-N-pyrazin-2-ylanilino)methyl]-7,8-difluoro-1H-quinolin-2-one
   Show/Hide
C20H13ClF2N4O
  1
1
IC50 = 12 nM
 Bioactivity Info 
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CP0392783
 Compound Info 
7,8-difluoro-4-[[(2-methylphenyl)methyl-pyrazin-2-ylamino]methyl]-1H-quinolin-2-one
   Show/Hide
C22H18F2N4O
  1
1
IC50 = 46 nM
 Bioactivity Info 
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CP0392785
 Compound Info 
4-[[(2-chlorophenyl)methyl-pyrazin-2-ylamino]methyl]-7,8-difluoro-1H-quinolin-2-one
   Show/Hide
C21H15ClF2N4O
  1
1
IC50 = 60 nM
 Bioactivity Info 
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CP0456823
 Compound Info 
4-[(3-chloro-N-(1-methylpyrazolo[3,4-d]pyrimidin-4-yl)anilino)methyl]-7,8-difluoro-1H-quinolin-2-one
   Show/Hide
C22H15ClF2N6O
  1
1
IC50 = 62 nM
 Bioactivity Info 
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CP0495466
 Compound Info 
7,8-difluoro-4-[[(2-fluorophenyl)methyl-pyrazin-2-ylamino]methyl]-1H-quinolin-2-one
   Show/Hide
C21H15F3N4O
  1
1
IC50 = 64 nM
 Bioactivity Info 
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CP0476554
 Compound Info 
4-[(3-chloro-N-pyrimidin-2-ylanilino)methyl]-7,8-difluoro-1H-quinolin-2-one
   Show/Hide
C20H13ClF2N4O
  1
1
IC50 = 69 nM
 Bioactivity Info 
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CP0476493
 Compound Info 
4-[[benzyl(pyrazin-2-yl)amino]methyl]-7,8-difluoro-1H-quinolin-2-one
   Show/Hide
C21H16F2N4O
  1
1
IC50 = 100 nM
 Bioactivity Info 
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CP0459747
 Compound Info 
4-[[(4-chlorophenyl)methyl-pyrazin-2-ylamino]methyl]-7,8-difluoro-1H-quinolin-2-one
   Show/Hide
C21H15ClF2N4O
  1
1
IC50 = 120 nM
 Bioactivity Info 
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CP0392787
 Compound Info 
4-[(3-chloro-N-(6-methoxypyrimidin-4-yl)anilino)methyl]-7,8-difluoro-1H-quinolin-2-one
   Show/Hide
C21H15ClF2N4O2
  1
1
IC50 = 130 nM
 Bioactivity Info 
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CP0482035
 Compound Info 
4-[(3-chloro-N-pyrimidin-4-ylanilino)methyl]-7,8-difluoro-1H-quinolin-2-one
   Show/Hide
C20H13ClF2N4O
  1
1
IC50 = 150 nM
 Bioactivity Info 
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CP0431257
 Compound Info 
4-[(3-chloro-N-(6-methylpyrimidin-4-yl)anilino)methyl]-7,8-difluoro-1H-quinolin-2-one
   Show/Hide
C21H15ClF2N4O
  1
1
IC50 = 160 nM
 Bioactivity Info 
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CP0459746
 Compound Info 
4-[(3-chloro-N-pyridin-2-ylanilino)methyl]-7,8-difluoro-1H-quinolin-2-one
   Show/Hide
C21H14ClF2N3O
  1
1
IC50 = 170 nM
 Bioactivity Info 
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CP0392784
 Compound Info 
4-[(3-chloro-N-(2-methylpyrimidin-4-yl)anilino)methyl]-7,8-difluoro-1H-quinolin-2-one
   Show/Hide
C21H15ClF2N4O
  1
1
IC50 = 213 nM
 Bioactivity Info 
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CP0476552
 Compound Info 
4-[(3-chloro-N-pyridin-4-ylanilino)methyl]-7,8-difluoro-1H-quinolin-2-one
   Show/Hide
C21H14ClF2N3O
  1
1
IC50 = 240 nM
 Bioactivity Info 
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CP0392786
 Compound Info 
4-[[(3-chlorophenyl)methyl-pyrazin-2-ylamino]methyl]-7,8-difluoro-1H-quinolin-2-one
   Show/Hide
C21H15ClF2N4O
  1
1
IC50 = 330 nM
 Bioactivity Info 
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CP0482036
 Compound Info 
4-[(3-chloro-N-pyridazin-3-ylanilino)methyl]-7,8-difluoro-1H-quinolin-2-one
   Show/Hide
C20H13ClF2N4O
  1
1
IC50 = 360 nM
 Bioactivity Info 
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CP0476491
 Compound Info 
4-[(3-chloro-N-pyridin-3-ylanilino)methyl]-7,8-difluoro-1H-quinolin-2-one
   Show/Hide
C21H14ClF2N3O
  1
1
IC50 = 370 nM
 Bioactivity Info 
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CP0502839
 Compound Info 
7,8-difluoro-4-[[pyrazin-2-yl(pyridin-2-ylmethyl)amino]methyl]-1H-quinolin-2-one
   Show/Hide
C20H15F2N5O
  1
1
IC50 = 440 nM
 Bioactivity Info 
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CP0459745
 Compound Info 
4-[(3-chloro-N-[6-(dimethylamino)pyrimidin-4-yl]anilino)methyl]-7,8-difluoro-1H-quinolin-2-one
   Show/Hide
C22H18ClF2N5O
  1
1
IC50 = 500 nM
 Bioactivity Info 
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CP0496280
 Compound Info 
4-[(3-chloro-N-pyrimidin-5-ylanilino)methyl]-7,8-difluoro-1H-quinolin-2-one
   Show/Hide
C20H13ClF2N4O
  1
1
IC50 = 1600 nM
 Bioactivity Info 
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Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0205776
 Compound Info 
(+/-)-6-((4-(2-(3-fluorophenethylamino)ethoxy)pyrrolidin-3-yl)methyl)-4-methylpyridin-2-amine
   Show/Hide
C21H29FN4O
  2
1 IC50 = 600 nM
2 IC50 = 700 nM
CP0046958
 Compound Info 
1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[PIPERIDINE-4,2'(1'H)-QUINAZOLINE]-4'-AMINE
   Show/Hide
C19H16F2N6O
  4
1 IC50 = 740 nM
2 IC50 = 741.31 nM
3 IC50 = 790 nM
4 IC50 = 1000 nM
CP0053263
 Compound Info 
(2S)-2-azaniumyl-5-[(N'-methylcarbamimidoyl)amino]pentanoate
   Show/Hide
C7H16N4O2
  6
1 IC50 = 890 nM
2 IC50 = 950 nM
3 IC50 = 2700 nM
4 IC50 = 4900 nM
5 IC50 = 10000 nM
6 Ki = 840 nM
CP0044041
 Compound Info 
(L-N6-1-iminoethyl)lysine
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C8H17N3O2
  7
1 IC50 = 1500 nM
2 IC50 = 1600 nM
3 IC50 = 17500 nM
4 IC50 = 18400 nM
5 IC50 = 35000 nM
6 IC50 = 61000 nM
7 IC50 = 61659.5 nM
CP0052287
 Compound Info 
(2S)-5-{[(Z)-amino(imino)methyl]amino}-2-(methylamino)pentanoic acid
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C7H16N4O2
  1
1 IC50 = 4300 nM
CP0042227
 Compound Info 
(S)-4-(2-Acetimidoylamino-ethylsulfanyl)-2-amino-butyric acid
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C8H17N3O2S
  1
1 IC50 = 18000 nM
CP0102624
 Compound Info 
N'-[(3R,4R)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl]-N-[2-(3-fluorophenyl)ethyl]ethane-1,2-diamine
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C21H30FN5
  1
1 Ki = 5.3 nM
CP0088832
 Compound Info 
(+/-)-cis-N1-((3S,4S)-4-((6-amino-4-methylpyridin-2-yl)methyl)pyrrolidin-3-yl)-N2-(3-fluorophenethyl)ethane-1,2-diamine
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C21H30FN5
  1
1 Ki = 52 nM
CP0040036
 Compound Info 
(S)-5-Acetimidoylamino-2-amino-pent
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C7H15N3O2
  2
1 Ki = 230 nM
2 Ki = 1700 nM
Clinical Information about the Protein
Target 1 ( Nitric-oxide synthase brain (NOS1) )
Target Type Clinical trial Target