Protein Information

General Information of the Protein

Protein ID	PT01324
Protein Name	Adenosylhomocysteinase
Secondarily Protein Name	S-adenosyl-L-homocysteine hydrolase
Gene Name	AHCY
Secondarily Gene Name	SAHH
Sequence	MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme > Hydrolase
Function	Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (PubMed:10933798). Binds copper ions (By similarity). Show/Hide
Uniprot ID	Primary ID: P23526 Secondarily ID: A8K307 B3KUN3 E1P5P2 F5H737 Q96A36 Show/Hide
Ensembl ID	ENSG00000101444
HGNC ID	HGNC:343
Subcellular Location	Cytoplasm Melanosome Nucleus Endoplasmic reticulum

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000004 , SH-SY5Y

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0159077 Compound Info	(1R,2S,3R)-3-(4-amino-7-fluoroimidazo[4,5-c]pyridin-1-yl)cyclopentane-1,2-diol Show/Hide	C11H13FN4O2	1
1	IC50 = 1.3 nM Bioactivity Info	TI LI LO TS
CP0162331 Compound Info	(1R,2S,3R)-3-(6-amino-9H-purin-9-yl)cyclopentane-1,2-diol Show/Hide	C10H13N5O2	1
1	IC50 = 1.5 nM Bioactivity Info	TI LI LO TS
CP0558930 Compound Info	(1R,2S,3S)-3-(8-aminoimidazo[1,2-a]pyrazin-3-yl)cyclopentane-1,2-diol Show/Hide	C11H14N4O2	1
1	IC50 = 1.5 nM Bioactivity Info	TI LI LO TS
CP0413614 Compound Info	(1R,2S,3R)-3-(4-amino-7-chloroimidazo[4,5-c]pyridin-1-yl)cyclopentane-1,2-diol Show/Hide	C11H13ClN4O2	1
1	IC50 = 2.2 nM Bioactivity Info	TI LI LO TS
CP0571080 Compound Info	(1R,2S,3S)-3-(4-amino-7-fluoroimidazo[4,5-c]pyridin-1-yl)-4-fluorocyclopentane-1,2-diol Show/Hide	C11H12F2N4O2	1
1	IC50 = 2.7 nM Bioactivity Info	TI LI LO TS
CP0571078 Compound Info	(1S,2R,3S,4R)-4-(4-amino-7-fluoroimidazo[4,5-c]pyridin-1-yl)cyclopentane-1,2,3-triol Show/Hide	C11H13FN4O3	1
1	IC50 = 9.4 nM Bioactivity Info	TI LI LO TS
CP0089788 Compound Info	(1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-hydroxymethyl-cyclopent-3-ene-1,2-diol Show/Hide	C11H13N5O3	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0213754 Compound Info	(1S,2R,5R)-5-(4-amino-7-fluoroimidazo[4,5-c]pyridin-1-yl)cyclopent-3-ene-1,2-diol Show/Hide	C11H11FN4O2	1
1	IC50 = 28 nM Bioactivity Info	TI LI LO TS
CP0571077 Compound Info	(1R,2S,3R)-3-(4-amino-7-methylimidazo[4,5-c]pyridin-1-yl)cyclopentane-1,2-diol Show/Hide	C12H16N4O2	1
1	IC50 = 36 nM Bioactivity Info	TI LI LO TS
CP0396844 Compound Info	(1S,2S,3R,5S)-3-(4-amino-7-fluoroimidazo[4,5-c]pyridin-1-yl)-5-fluorocyclopentane-1,2-diol Show/Hide	C11H12F2N4O2	1
1	IC50 = 41 nM Bioactivity Info	TI LI LO TS
CP0245759 Compound Info	(1R,2S,3R)-3-(6-amino-2-fluoropurin-9-yl)cyclopentane-1,2-diol Show/Hide	C10H12FN5O2	1
1	IC50 = 98 nM Bioactivity Info	TI LI LO TS
CP0302914 Compound Info	(1R,2S,3R)-3-(4-amino-6,7-difluoroimidazo[4,5-c]pyridin-1-yl)cyclopentane-1,2-diol Show/Hide	C11H12F2N4O2	1
1	IC50 = 189 nM Bioactivity Info	TI LI LO TS
CP0278797 Compound Info	(1S,2S,3R,5R)-3-(4-amino-7-fluoroimidazo[4,5-c]pyridin-1-yl)-5-fluorocyclopentane-1,2-diol Show/Hide	C11H12F2N4O2	1
1	IC50 = 672 nM Bioactivity Info	TI LI LO TS
CP0245394 Compound Info	(1'R,2'S,3'R)-9-(2',3'-dihydroxycyclopent-4'-enyl)adenine Show/Hide	C10H11N5O2	1
1	IC50 = 877 nM Bioactivity Info	TI LI LO TS
CP0506669 Compound Info	(1R,2R,3S,4R)-4-(4-amino-7-fluoroimidazo[4,5-c]pyridin-1-yl)cyclopentane-1,2,3-triol Show/Hide	C11H13FN4O3	1
1	IC50 = 878 nM Bioactivity Info	TI LI LO TS
CP0103621 Compound Info	(1S,2R,5R)-5-(6-aminopurin-9-yl)-3-(chloromethyl)cyclopent-3-ene-1,2-diol Show/Hide	C11H12ClN5O2	1
1	IC50 = 939 nM Bioactivity Info	TI LI LO TS
CP0259017 Compound Info	(1R,2R,3S,4R,5S)-4-(4-amino-7-fluoroimidazo[4,5-c]pyridin-1-yl)bicyclo[3.1.0]hexane-2,3-diol Show/Hide	C12H13FN4O2	1
1	IC50 = 1960 nM Bioactivity Info	TI LI LO TS
CP0278795 Compound Info	(1R,2S,3R)-3-(6-amino-8-chloropurin-9-yl)cyclopentane-1,2-diol Show/Hide	C10H12ClN5O2	1
1	IC50 = 2100 nM Bioactivity Info	TI LI LO TS
CP0086138 Compound Info	(1R,2S,3R)-3-(6-amino-8-fluoropurin-9-yl)cyclopentane-1,2-diol Show/Hide	C10H12FN5O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0259016 Compound Info	(1R,2S,3R)-3-(6-amino-8-bromopurin-9-yl)cyclopentane-1,2-diol Show/Hide	C10H12BrN5O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0089788 Compound Info	(1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-hydroxymethyl-cyclopent-3-ene-1,2-diol Show/Hide	C11H13N5O3	4
1	IC50 = 1.5 nM
2	IC50 = 7.2 nM
3	IC50 = 15.194105 nM
4	IC50 = 900 nM
CP0413614 Compound Info	(1R,2S,3R)-3-(4-amino-7-chloroimidazo[4,5-c]pyridin-1-yl)cyclopentane-1,2-diol Show/Hide	C11H13ClN4O2	1
1	IC50 = 16 nM
CP0571078 Compound Info	(1S,2R,3S,4R)-4-(4-amino-7-fluoroimidazo[4,5-c]pyridin-1-yl)cyclopentane-1,2,3-triol Show/Hide	C11H13FN4O3	1
1	IC50 = 24 nM
CP0159077 Compound Info	(1R,2S,3R)-3-(4-amino-7-fluoroimidazo[4,5-c]pyridin-1-yl)cyclopentane-1,2-diol Show/Hide	C11H13FN4O2	1
1	IC50 = 40 nM
CP0162331 Compound Info	(1R,2S,3R)-3-(6-amino-9H-purin-9-yl)cyclopentane-1,2-diol Show/Hide	C10H13N5O2	2
1	IC50 = 55 nM
2	IC50 = 18000 nM
CP0103621 Compound Info	(1S,2R,5R)-5-(6-aminopurin-9-yl)-3-(chloromethyl)cyclopent-3-ene-1,2-diol Show/Hide	C11H12ClN5O2	2
1	IC50 = 195 nM
2	IC50 > 35498.75754 nM
CP0571077 Compound Info	(1R,2S,3R)-3-(4-amino-7-methylimidazo[4,5-c]pyridin-1-yl)cyclopentane-1,2-diol Show/Hide	C12H16N4O2	1
1	IC50 = 236 nM
CP0558930 Compound Info	(1R,2S,3S)-3-(8-aminoimidazo[1,2-a]pyrazin-3-yl)cyclopentane-1,2-diol Show/Hide	C11H14N4O2	1
1	IC50 = 250 nM
CP0396844 Compound Info	(1S,2S,3R,5S)-3-(4-amino-7-fluoroimidazo[4,5-c]pyridin-1-yl)-5-fluorocyclopentane-1,2-diol Show/Hide	C11H12F2N4O2	1
1	IC50 = 269 nM
CP0571080 Compound Info	(1R,2S,3S)-3-(4-amino-7-fluoroimidazo[4,5-c]pyridin-1-yl)-4-fluorocyclopentane-1,2-diol Show/Hide	C11H12F2N4O2	1
1	IC50 = 455 nM
CP0245759 Compound Info	(1R,2S,3R)-3-(6-amino-2-fluoropurin-9-yl)cyclopentane-1,2-diol Show/Hide	C10H12FN5O2	1
1	IC50 = 2124 nM
CP0302914 Compound Info	(1R,2S,3R)-3-(4-amino-6,7-difluoroimidazo[4,5-c]pyridin-1-yl)cyclopentane-1,2-diol Show/Hide	C11H12F2N4O2	1
1	IC50 = 3644 nM
CP0245394 Compound Info	(1'R,2'S,3'R)-9-(2',3'-dihydroxycyclopent-4'-enyl)adenine Show/Hide	C10H11N5O2	1
1	IC50 = 4125 nM
CP0213754 Compound Info	(1S,2R,5R)-5-(4-amino-7-fluoroimidazo[4,5-c]pyridin-1-yl)cyclopent-3-ene-1,2-diol Show/Hide	C11H11FN4O2	1
1	IC50 = 9690 nM
CP0086138 Compound Info	(1R,2S,3R)-3-(6-amino-8-fluoropurin-9-yl)cyclopentane-1,2-diol Show/Hide	C10H12FN5O2	1
1	IC50 > 10000 nM
CP0259016 Compound Info	(1R,2S,3R)-3-(6-amino-8-bromopurin-9-yl)cyclopentane-1,2-diol Show/Hide	C10H12BrN5O2	1
1	IC50 > 10000 nM
CP0259017 Compound Info	(1R,2R,3S,4R,5S)-4-(4-amino-7-fluoroimidazo[4,5-c]pyridin-1-yl)bicyclo[3.1.0]hexane-2,3-diol Show/Hide	C12H13FN4O2	1
1	IC50 > 10000 nM
CP0278795 Compound Info	(1R,2S,3R)-3-(6-amino-8-chloropurin-9-yl)cyclopentane-1,2-diol Show/Hide	C10H12ClN5O2	1
1	IC50 > 10000 nM
CP0278797 Compound Info	(1S,2S,3R,5R)-3-(4-amino-7-fluoroimidazo[4,5-c]pyridin-1-yl)-5-fluorocyclopentane-1,2-diol Show/Hide	C11H12F2N4O2	1
1	IC50 > 10000 nM
CP0506669 Compound Info	(1R,2R,3S,4R)-4-(4-amino-7-fluoroimidazo[4,5-c]pyridin-1-yl)cyclopentane-1,2,3-triol Show/Hide	C11H13FN4O3	1
1	IC50 > 10000 nM

Clinical Information about the Protein

Target 1 ( Adenosylhomocysteinase (AHCY) )

Target Type	Literature-reported Target

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han