General Information of the Protein
Protein ID
PT01157
Protein Name
Serine/threonine-protein kinase RIO2
Secondarily
Protein Name
RIO kinase 2
Gene Name
RIOK2
Secondarily
Gene Name
RIO2
Sequence
MGKVNVAKLRYMSRDDFRVLTAVEMGMKNHEIVPGSLIASIASLKHGGCNKVLRELVKHKLIAWERTKTVQGYRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESDIYIVANEEGQQFALKLHRLGRTSFRNLKNKRDYHKHRHNVSWLYLSRLSAMKEFAYMKALYERKFPVPKPIDYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLANHGLIHGDFNEFNLILDESDHITMIDFPQMVSTSHPNAEWYFDRDVKCIKDFFMKRFSYESELFPTFKDIRREDTLDVEVSASGYTKEMQADDELLHPLGPDDKNIETKEGSEFSFSDGEVAEKAEVYGSENESERNCLEESEGCYCRSSGDPEQIKEDSLSEESADARSFEMTEFNQALEEIKGQVVENNSVTEFSEEKNRTENYNRQDGQRVQGGVPAGSDEYEDECPHLIALSSLNREFRPFRDEENVGAMNQYRTRTLSITSSGSAVSCSTIPPELVKQKVKRQLTKQQKSAVRRRLQKGEANIFTKQRRENMQNIKSSLEAASFWGE
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
Atypical protein kinase group
>
Atypical protein kinase RIO family
>
Atypical protein kinase RIO2 subfamily
Function
Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710).
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Uniprot ID
Primary ID:
Q9BVS4

Secondarily ID:
D6RDI3
Q9NUT0
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Ensembl ID
ENSG00000058729
HGNC ID
HGNC:18999
Subcellular Location
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0357722
 Compound Info 
N-(4-chloropyridin-2-yl)-2-naphthalen-2-ylacetamide
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C17H13ClN2O
  1
1
IC50 = 5000 nM
 Bioactivity Info 
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CP0232829
 Compound Info 
2-(6-methoxynaphthalen-2-yl)-N-(4-methylpyridin-2-yl)propanamide
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C20H20N2O2
  1
1
IC50 = 5200 nM
 Bioactivity Info 
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CP0280945
 Compound Info 
N-(4-methoxypyridin-2-yl)-2-naphthalen-2-ylacetamide
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C18H16N2O2
  1
1
IC50 = 5200 nM
 Bioactivity Info 
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CP0535039
 Compound Info 
(2S)-2-(6-methoxynaphthalen-2-yl)-N-(4-methoxypyridin-2-yl)propanamide
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C20H20N2O3
  1
1
IC50 = 5300 nM
 Bioactivity Info 
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CP0232830
 Compound Info 
(2S)-2-(6-methoxynaphthalen-2-yl)-N-(4-methylpyridin-2-yl)propanamide
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C20H20N2O2
  1
1
IC50 = 6600 nM
 Bioactivity Info 
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CP0529987
 Compound Info 
2-naphthalen-2-yl-N-[4-(trifluoromethyl)pyridin-2-yl]acetamide
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C18H13F3N2O
  1
1
IC50 = 7500 nM
 Bioactivity Info 
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CP0534307
 Compound Info 
N-(4-methoxypyridin-2-yl)-2-(4-phenylphenyl)acetamide
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C20H18N2O2
  1
1
IC50 = 7600 nM
 Bioactivity Info 
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CP0565602
 Compound Info 
(2R)-2-(6-methoxynaphthalen-2-yl)-N-(4-methylpyridin-2-yl)propanamide
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C20H20N2O2
  1
1
IC50 = 7600 nM
 Bioactivity Info 
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CP0532962
 Compound Info 
N-(4-bromopyridin-2-yl)-2-naphthalen-2-ylacetamide
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C17H13BrN2O
  1
1
IC50 = 13400 nM
 Bioactivity Info 
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CP0547445
 Compound Info 
N-(4-ethylpyridin-2-yl)-2-naphthalen-2-ylacetamide
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C19H18N2O
  1
1
IC50 = 14500 nM
 Bioactivity Info 
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CP0232831
 Compound Info 
N-(4-methylpyridin-2-yl)-2-naphthalen-2-ylacetamide
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C18H16N2O
  1
1
IC50 = 14600 nM
 Bioactivity Info 
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CP0532968
 Compound Info 
2-(3,4-dimethylphenyl)-N-(4-methoxypyridin-2-yl)acetamide
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C16H18N2O2
  1
1
IC50 = 28000 nM
 Bioactivity Info 
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CP0492127
 Compound Info 
2-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-(4-methylpyridin-2-yl)acetamide
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C16H16N2O3
  1
1
IC50 > 30000 nM
 Bioactivity Info 
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CP0529988
 Compound Info 
N-(4-methylpyridin-2-yl)-3-naphthalen-2-ylpropanamide
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C19H18N2O
  1
1
IC50 > 30000 nM
 Bioactivity Info 
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CP0532963
 Compound Info 
2-(1,3-benzodioxol-5-yl)-N-(4-methylpyridin-2-yl)acetamide
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C15H14N2O3
  1
1
IC50 > 30000 nM
 Bioactivity Info 
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CP0555700
 Compound Info 
N-(4-methylpyridin-2-yl)-2-naphthalen-2-yloxyacetamide
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C18H16N2O2
  1
1
IC50 > 30000 nM
 Bioactivity Info 
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Cell Line ID: CL000700 , VCaP
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0232831
 Compound Info 
N-(4-methylpyridin-2-yl)-2-naphthalen-2-ylacetamide
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C18H16N2O
  1
1 Kd = 140 nM