General Information of the Protein
Protein ID
PT01146
Protein Name
P-selectin
Secondarily
Protein Name
CD62 antigen-like family member P
Granule membrane protein 140
Leukocyte-endothelial cell adhesion molecule 3
Platelet activation dependent granule-external membrane protein
Gene Name
SELP
Secondarily
Gene Name
GMRP
GRMP
Sequence
MANCQIAILYQRFQRVVFGISQLLCFSALISELTNQKEVAAWTYHYSTKAYSWNISRKYCQNRYTDLVAIQNKNEIDYLNKVLPYYSSYYWIGIRKNNKTWTWVGTKKALTNEAENWADNEPNNKRNNEDCVEIYIKSPSAPGKWNDEHCLKKKHALCYTASCQDMSCSKQGECLETIGNYTCSCYPGFYGPECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQAGPLTIQEALTYFGGAVASTIGLIMGGTLLALLRKRFRQKDDGKCPLNPHSHLGTYGVFTNAAFDPSP
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Organism
Homo sapiens, Human
Protein Classification
Adhesion
Function
Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG.
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Uniprot ID
Primary ID:
P16109

Secondarily ID:
Q5R344
Q8IVD1
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Ensembl ID
ENSG00000174175
HGNC ID
HGNC:10721
Subcellular Location
Cell membrane
Clinical Information about the Protein
Target 1 ( P-selectin (SELP) )
Target Type Successful Target
Disease 2 Target-related Diseases  2
1 Influenza virus infection [ICD-11: 1E30-1E32]
2 Thrombosis [ICD-11: DB61-GB90]
Clinical Trial Drug(s) 2 Clinical Trial Drugs  2
1 BAICALEIN
 Drug Info 
Phase 2
Influenza virus infection
2 PSI-697
 Drug Info 
Phase 1
Thrombosis