General Information of the Protein
Protein ID
PT00960
Protein Name
STE20-like serine/threonine-protein kinase
Secondarily
Protein Name
CTCL tumor antigen se20-9
STE20-related serine/threonine-protein kinase
Serine/threonine-protein kinase 2
Gene Name
SLK
Secondarily
Gene Name
KIAA0204
STK2
Sequence
MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEVPIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADTDQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSGENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
STE protein kinase group
>
STE protein kinase STE20 family
>
STE protein kinase SLK subfamily
Function
Mediates apoptosis and actin stress fiber dissolution.
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Uniprot ID
Primary ID:
Q9H2G2

Secondarily ID:
D3DRA0
D3DRA1
O00211
Q6P1Z4
Q86WU7
Q86WW1
Q92603
Q9NQL0
Q9NQL1
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Ensembl ID
ENSG00000065613
HGNC ID
HGNC:11088
Subcellular Location
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0109175
 Compound Info 
3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
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C17H13ClN2O3
  1
1
IC50 = 700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0011976
 Compound Info 
3-[[4-(2-methoxyphenyl)-2,5-dioxopyrrol-3-yl]amino]benzonitrile
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C18H13N3O3
  1
1
IC50 = 1200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0539741
 Compound Info 
3-[[4-(4-bromo-2-methoxyphenyl)-2,5-dioxopyrrol-3-yl]amino]benzonitrile
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C18H12BrN3O3
  1
1
IC50 = 17000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0356534
 Compound Info 
3-[[4-(5-bromo-2-methoxyphenyl)-2,5-dioxopyrrol-3-yl]amino]benzonitrile
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C18H12BrN3O3
  1
1
IC50 = 19000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0176862
 Compound Info 
3-(2-methoxyphenyl)-4-(naphthalen-1-ylamino)pyrrole-2,5-dione
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C21H16N2O3
  1
1
IC50 > 20000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0109175
 Compound Info 
3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
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C17H13ClN2O3
  2
1 IC50 = 7.8 nM
2 Ki = 6.6 nM
CP0011976
 Compound Info 
3-[[4-(2-methoxyphenyl)-2,5-dioxopyrrol-3-yl]amino]benzonitrile
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C18H13N3O3
  2
1 IC50 = 8.2 nM
2 Ki = 3.7 nM
CP0539741
 Compound Info 
3-[[4-(4-bromo-2-methoxyphenyl)-2,5-dioxopyrrol-3-yl]amino]benzonitrile
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C18H12BrN3O3
  1
1 Ki = 3.9 nM
CP0176862
 Compound Info 
3-(2-methoxyphenyl)-4-(naphthalen-1-ylamino)pyrrole-2,5-dione
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C21H16N2O3
  1
1 Ki = 6 nM
CP0356534
 Compound Info 
3-[[4-(5-bromo-2-methoxyphenyl)-2,5-dioxopyrrol-3-yl]amino]benzonitrile
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C18H12BrN3O3
  1
1 Ki = 9.7 nM
Clinical Information about the Protein
Target 1 ( STE20-related serine/threonine-protein kinase (SLK) )
Target Type Literature-reported Target