Protein Information

General Information of the Protein

Protein ID	PT00841
Protein Name	Carbonic anhydrase 12
Secondarily Protein Name	Carbonate dehydratase XII Carbonic anhydrase XII Tumor antigen HOM-RCC-3.1.3
Gene Name	CA12
Sequence	MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme > Lyase
Function	Reversible hydration of carbon dioxide. Show/Hide
Uniprot ID	Primary ID: O43570 Secondarily ID: B2RE24 Q53YE5 Q9BWG2 Show/Hide
Ensembl ID	ENSG00000074410
HGNC ID	HGNC:1371
Subcellular Location	Membrane Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0426190 Compound Info	[4-(1-benzofuran-5-yl)phenyl] N,N-dimethylsulfamate Show/Hide	C16H15NO4S	1
1	IC50 = 170 nM Bioactivity Info	TI LI LO TS
CP0426194 Compound Info	[4-(1-benzofuran-5-yl)phenyl] cyclohexanesulfonate Show/Hide	C20H20O4S	1
1	IC50 = 170 nM Bioactivity Info	TI LI LO TS
CP0412939 Compound Info	[4-(1-benzothiophen-5-yl)phenyl] benzenesulfonate Show/Hide	C20H14O3S2	1
1	IC50 = 250 nM Bioactivity Info	TI LI LO TS
CP0426192 Compound Info	[4-(1-benzofuran-5-yl)phenyl] 4-fluorobenzenesulfonate Show/Hide	C20H13FO4S	1
1	IC50 = 270 nM Bioactivity Info	TI LI LO TS
CP0532862 Compound Info	[4-(1-benzothiophen-5-yl)phenyl] propane-1-sulfonate Show/Hide	C17H16O3S2	1
1	IC50 = 310 nM Bioactivity Info	TI LI LO TS
CP0540809 Compound Info	[4-(1-benzofuran-5-yl)phenyl] benzenesulfonate Show/Hide	C20H14O4S	1
1	IC50 = 490 nM Bioactivity Info	TI LI LO TS
CP0540808 Compound Info	[4-(1-benzofuran-5-yl)phenyl] methanesulfonate Show/Hide	C15H12O4S	1
1	IC50 = 540 nM Bioactivity Info	TI LI LO TS
CP0412940 Compound Info	[4-(1-benzothiophen-5-yl)phenyl] methanesulfonate Show/Hide	C15H12O3S2	1
1	IC50 = 870 nM Bioactivity Info	TI LI LO TS
CP0528252 Compound Info	[4-(1-benzothiophen-5-yl)phenyl] ethanesulfonate Show/Hide	C16H14O3S2	1
1	IC50 = 920 nM Bioactivity Info	TI LI LO TS
CP0532863 Compound Info	[4-(1-benzothiophen-5-yl)phenyl] cyclohexanesulfonate Show/Hide	C20H20O3S2	1
1	IC50 = 970 nM Bioactivity Info	TI LI LO TS
CP0566420 Compound Info	[4-(1-benzofuran-5-yl)phenyl] 4-methylbenzenesulfonate Show/Hide	C21H16O4S	1
1	IC50 = 1130 nM Bioactivity Info	TI LI LO TS
CP0034627 Compound Info	AZA Show/Hide	C4H6N4O3S2	1
1	IC50 = 1550 nM Bioactivity Info	TI LI LO TS
CP0412941 Compound Info	[4-(1-benzothiophen-5-yl)phenyl] sulfamate Show/Hide	C14H11NO3S2	1
1	IC50 = 1600 nM Bioactivity Info	TI LI LO TS
CP0426191 Compound Info	[4-(1-benzofuran-5-yl)phenyl] N-methylsulfamate Show/Hide	C15H13NO4S	1
1	IC50 = 2230 nM Bioactivity Info	TI LI LO TS
CP0528253 Compound Info	[4-(1-benzothiophen-5-yl)phenyl] N,N-dimethylsulfamate Show/Hide	C16H15NO3S2	1
1	IC50 = 2330 nM Bioactivity Info	TI LI LO TS
CP0530321 Compound Info	[4-(1-benzothiophen-5-yl)phenyl] 4-fluorobenzenesulfonate Show/Hide	C20H13FO3S2	1
1	IC50 = 2870 nM Bioactivity Info	TI LI LO TS
CP0528248 Compound Info	[4-(1-benzothiophen-5-yl)phenyl] 4-methylbenzenesulfonate Show/Hide	C21H16O3S2	1
1	IC50 = 2890 nM Bioactivity Info	TI LI LO TS
CP0528251 Compound Info	[4-(1-benzofuran-5-yl)phenyl] propane-1-sulfonate Show/Hide	C17H16O4S	1
1	IC50 = 3700 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000013 , Sf9

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0034627 Compound Info	AZA Show/Hide	C4H6N4O3S2	19
1	IC50 = 5.7 nM
2	IC50 = 60 nM
3	IC50 = 61 nM
4	IC50 = 88 nM
5	Kd = 25 nM
6	Kd = 130 nM
7	Kd = 133 nM
8	Kd = 330 nM
9	Ki = 2.5 nM
10	Ki = 3 nM
11	Ki = 5 nM
12	Ki = 5.6 nM
13	Ki = 5.7 nM
14	Ki = 5.8 nM
15	Ki = 6 nM
16	Ki = 12 nM
17	Ki = 25 nM
18	Ki = 250 nM
19	Km = 12000000 nM
CP0037494 Compound Info	(2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H-1,7-thieno[2,3-b]thiopyran-6-sulfonamide Show/Hide	C10H16N2O4S3	2
1	Ki = 3 nM
2	Ki = 3.5 nM

Clinical Information about the Protein

Target 1 ( Carbonic anhydrase XII (CA-XII) )

Target Type	Successful Target
Disease	4 Target-related Diseases				4
1	Seborrhoeic dermatitis [ICD-11: EA81]
2	Bacterial infection [ICD-11: 1A00-1C4Z]
3	Solid tumour/cancer [ICD-11: 2A00-2F9Z]
4	Breast cancer [ICD-11: 2C60-2C65]
Approved Drug(s)	2 Approved Drugs				2
1	Salicyclic acid	Drug Info	Approved	Seborrhoeic dermatitis
2	Sulfamylon	Drug Info	Approved	Bacterial infection
Clinical Trial Drug(s)	2 Clinical Trial Drugs				2
1	Curcumin	Drug Info	Phase 3	Solid tumour/cancer
2	Coumate	Drug Info	Phase 2	Breast cancer
Investigative Drug(s)	1 Investigative Drug				1
1	CL-5343	Drug Info	Investigative	Solid tumour/cancer

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han