General Information of the Protein
Protein ID
PT00701
Protein Name
Signal peptide peptidase-like 2A
Gene Name
SPPL2A
Sequence
MGLLHSLHAPAAALLWSCLLGLSAAQEAILHASANGVSSLSKDYCMYYNNNWTRLPSSLENATSLSLMNLTGTPLCHLSDIPPDGIKNKAVVVHWGPCHFLEKAKIAQEGGAAALLIANNSVLIPSSRNKSAFQNVTILIAVITQKDFNDMKETLGDDITVKMYSPSWPNFDYTLVVIFVIAVFTVALGGYWSGLIELESMKAVEDAEDREARKKKEDYLTFSPLTVVLFVVICCVMIVLLYFFYKWLVYVMIAIFCIASATSLYNCLAALIHRMPCGQCTILCCGKNIKVSLIFLSGLCISVAVVWAVFRNEDRWAWILQDILGIAFCLNLIKTMKLPNFMSCVILLGLLLIYDVFFVFITPFITKNGESIMVELAAGPFENAEKLPVVIRVPKLMDYSVMSVCSVPVSVLGFGDIIVPGLLIAYCRRFDVQTGSSIYYISSTIAYAVGMIITFVVLMVMKTGQPALLYLVPCTLITASIVAWSRKEMKKFWKGSSYQVMDYLDYSTNEENPAATDEQIVQQ
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Organism
Rattus norvegicus, Rat
Protein Classification
Enzyme
>
Protease
>
Aspartic protease
Uniprot ID
D3ZNG3
Ensembl ID
ENSG00000138600
Subcellular Location
Endosome membrane
Lysosome membrane
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000043 , U2OS
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0460550
 Compound Info 
(2S)-2-cyclopropyl-N-[(6S)-5,11-dioxospiro[3,6-dihydro-1H-pyrazolo[1,2-b][2,3]benzodiazepine-2,1'-cyclopropane]-6-yl]-N'-(5-fluoro-2-methylpyridin-3-yl)butanediamide
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C27H28FN5O4
  1
1
IC50 = 56 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT05844 Signal peptide peptidase-like 2A Mus musculus, Mouse
 Protein Info