General Information of the Protein
Protein ID
PT00681
Protein Name
Phosphodiesterase
Gene Name
PDE2A3
Sequence
MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESRLVCEDPPHELPQEGKVWEAIISQKRLGCNGLGLSDLPGKPLARLVAPLAPHTQVLVIPLVDKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQALQQRRPSEAPQAVQNPPEGAVEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSEDSLQLSCKVMGDKVLGEEISFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDQDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDESTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPEAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTGAPINGCCSLDAE
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Organism
Macaca mulatta, Rhesus macaque
Protein Classification
Enzyme
Uniprot ID
B3VTJ2
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000192 , AD-293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0468287
 Compound Info 
2-(dimethylamino)-N-[(1R)-2-methyl-1-[4-(trifluoromethylsulfanyl)phenyl]propyl]-6-oxo-1H-pyrimidine-4-carboxamide
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C18H21F3N4O2S
  1
1
Ki = 0.19 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0512495
 Compound Info 
2-(dimethylamino)-6-oxo-N-[(1R)-1-[4-(trifluoromethylsulfanyl)phenyl]propyl]-1H-pyrimidine-4-carboxamide
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C17H19F3N4O2S
  1
1
Ki = 0.51 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0565494
 Compound Info 
2-(dimethylamino)-6-oxo-N-[(1R)-1-[4-(trifluoromethylsulfanyl)phenyl]ethyl]-1H-pyrimidine-4-carboxamide
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C16H17F3N4O2S
  1
1
Ki = 0.57 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0466631
 Compound Info 
2-(dimethylamino)-N-[1-[3-fluoro-4-(trifluoromethyl)phenyl]cyclopropyl]-6-oxo-1H-pyrimidine-4-carboxamide
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C17H16F4N4O2
  1
1
Ki = 0.8 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0468288
 Compound Info 
N-[(1R)-1-[3-chloro-4-(trifluoromethoxy)phenyl]ethyl]-2-(dimethylamino)-6-oxo-1H-pyrimidine-4-carboxamide
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C16H16ClF3N4O3
  1
1
Ki = 0.82 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT02047 cGMP-dependent 3',5'-cyclic phosphodiesterase Homo sapiens, Human
 Protein Info