General Information of the Protein
Protein ID
PT00645
Protein Name
Glucocorticoid receptor
Secondarily
Protein Name
Nuclear receptor subfamily 3 group C member 1
Gene Name
NR3C1
Sequence
MDSKESLSPPSKEEISSSVLGRERGNVMDFYKTLRGGATVKVSASSPSLAAASQSDSKQQRLLVDFPKGSGSHAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDFRLLEESIANLNRSTSVPENPKSSVSAVSAAPTEKEFAQTLSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDVWRKKLQDLDFTSGSPEKEASESPWRSDLLIDENCLLSPLAGEDDPFLLEGNSNEDCKPLVLPDTKPKIKDNGDLILASPNSVPLPQVKTEKEDFIELCTPGVIKQEKLGPVYCQASFSGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLASLGTLNFPGRSVFSNGYSSPGMRPDVSSPPSSSSAATGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGRQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATPGASQETSENPANKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSGSMLCFAPDLIINEQRMTLPCMYDQCKHMLFVSSELQRLQVSYEEYLCMKTLLLLSSVPKEGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHDVVENLLNFCFQTFLDKTMSIEFPEMLAEIITNQIPKYSSGNIKKLLFHQK
    Show/Hide
Organism
Canis lupus familiaris, Dog, Canis familiaris
Protein Classification
Unclassified protein
Uniprot ID
A0A8C0QLS2
Ensembl ID
ENSG00000113580
Subcellular Location
Cytoplasm
Cytoskeleton
Microtubule organizing center
Centrosome
Cytoplasm
Cytoskeleton
Spindle
Mitochondrion
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000752 , PBMC iPSC #1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0035186
 Compound Info 
(10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]-14-hydroxy-15-methyl-14-(prop-1-yn-1-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-1,6-dien-5-one
   Show/Hide
C29H35NO2
  2
1
IC50 = 20.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 32.6 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0068675
 Compound Info 
(8R,9S,10R,11S,13S,14S,17S)-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-13-methyl-11-[4-[methyl(propan-2-yl)amino]phenyl]-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
   Show/Hide
C34H47NO2
  2
1
IC50 = 24.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 34.3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT00967 Glucocorticoid receptor Homo sapiens, Human
 Protein Info 
50% Identity
Protein ID Protein Name Protein Organism
PT00870 Glucocorticoid receptor Rattus norvegicus, Rat
 Protein Info 
PT03331 Glucocorticoid receptor Mus musculus, Mouse
 Protein Info 
PT07390 Glucocorticoid receptor Sus scrofa, Pig
 Protein Info