Protein Information

General Information of the Protein

Protein ID	PT00633
Protein Name	Heat sensitive channel TRPV3
Sequence	MKAHPKEMVPLMGKRTTAPGGNPAVLTEKRPADLTPTKKSAHFFLEIEGFEPNPTVTKTSPPIFSKPMDSNIRQCLSGNCDDMDSPQSPQDDVTETPSNPNSPSANLAKEEQRQKKKRLKKCIFAAVSEGCVRELRELLQDLQELCRRRRGLDASDFLMHKLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILDRFINAEYTEEAYEGQTALNIAIERRQGDITAVLIAAGADVNAHAKGVFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETMRNNDGLTPLQLAAKMGKAEILKYILGREIKEKPLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEIIVYNTNIDNRHEVLTLEPLHTLLHMKWKKFAKYMFFLSFCFYFSYNITLTLVSYYRPREGEALPHPLALTHKMSWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVIFGQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYILFLLGFGVALASLIEKCSKDKKDCSSYGSFSDAVLELFKLTIGLGGLNIQQNSTYPILFLFLLITYVILTFVLLLNMLIALMGETAENVSKESERIWRLQRARTTLEFEKMLPEWLRSRFRMGELCKVADEDFRLCLRINEVKWTEWKTHVSFLNEDPGPIRRTADSNKIQDSSRSNSKTTLYAFDELDEFPETSV Show/Hide
Organism	Rattus norvegicus, Rat
Protein Classification	Unclassified protein
Uniprot ID	Q4QYD9
Subcellular Location	Membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000006 , HEK293

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0410864 Compound Info	(1S,3E,7E,11E)-4,8,12-trimethyl-1-propan-2-ylcyclotetradeca-3,7,11-trien-1-ol Show/Hide	C20H34O	2
1	EC50 = 170 nM Bioactivity Info	TI LI LO TS
2	IC50 = 150 nM Bioactivity Info	TI LI LO TS
CP0410860 Compound Info	[(1R,2S,5E,9E,12S)-1,5,9-trimethyl-12-propan-2-yl-15-oxabicyclo[10.2.1]pentadeca-5,9-dien-2-yl] 2-phenylacetate Show/Hide	C28H40O3	2
1	EC50 = 1200 nM Bioactivity Info	TI LI LO TS
2	IC50 = 21700 nM Bioactivity Info	TI LI LO TS
CP0432892 Compound Info	[(1R,2S,5E,9E,12S)-1,5,9-trimethyl-12-propan-2-yl-15-oxabicyclo[10.2.1]pentadeca-5,9-dien-2-yl] acetate Show/Hide	C22H36O3	2
1	EC50 = 1400 nM Bioactivity Info	TI LI LO TS
2	IC50 = 2200 nM Bioactivity Info	TI LI LO TS
CP0475826 Compound Info	Incensole Show/Hide	C20H34O2	2
1	EC50 = 2100 nM Bioactivity Info	TI LI LO TS
2	IC50 = 2100 nM Bioactivity Info	TI LI LO TS
CP0401077 Compound Info	(1R,5E,9E,12S)-1,5,9-trimethyl-12-propan-2-yl-15-oxabicyclo[10.2.1]pentadeca-5,9-dien-2-one Show/Hide	C20H32O2	2
1	EC50 = 2400 nM Bioactivity Info	TI LI LO TS
2	IC50 = 5800 nM Bioactivity Info	TI LI LO TS
CP0385302 Compound Info	[(1R,2S,5E,9E,12S)-1,5,9-trimethyl-12-propan-2-yl-15-oxabicyclo[10.2.1]pentadeca-5,9-dien-2-yl] benzoate Show/Hide	C27H38O3	2
1	EC50 = 4400 nM Bioactivity Info	TI LI LO TS
2	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0475825 Compound Info	[(1R,2S,5E,9E,12S)-1,5,9-trimethyl-12-propan-2-yl-15-oxabicyclo[10.2.1]pentadeca-5,9-dien-2-yl] nonanoate Show/Hide	C29H50O3	2
1	EC50 = 5600 nM Bioactivity Info	TI LI LO TS
2	IC50 = 24100 nM Bioactivity Info	TI LI LO TS
CP0401078 Compound Info	(1R,2R,5E,9E,12S)-1,5,9-trimethyl-12-propan-2-yl-15-oxabicyclo[10.2.1]pentadeca-5,9-dien-2-ol Show/Hide	C20H34O2	2
1	EC50 = 7300 nM Bioactivity Info	TI LI LO TS
2	IC50 = 12300 nM Bioactivity Info	TI LI LO TS
CP0410862 Compound Info	[(1R,2S,5R,7S,10E,13S)-1,5,10-trimethyl-13-propan-2-yl-6,16-dioxatricyclo[11.2.1.05,7]hexadec-10-en-2-yl] acetate Show/Hide	C22H36O4	2
1	EC50 = 8600 nM Bioactivity Info	TI LI LO TS
2	IC50 = 21100 nM Bioactivity Info	TI LI LO TS
CP0410865 Compound Info	[(1S,3R,5S,8E,12S,13R)-5,9,13-trimethyl-1-propan-2-yl-4,16-dioxatricyclo[11.2.1.03,5]hexadec-8-en-12-yl] acetate Show/Hide	C22H36O4	2
1	EC50 = 8800 nM Bioactivity Info	TI LI LO TS
2	IC50 = 13200 nM Bioactivity Info	TI LI LO TS
CP0385303 Compound Info	[(1R,2S,5E,9E,12S)-1,5,9-trimethyl-12-propan-2-yl-15-oxabicyclo[10.2.1]pentadeca-5,9-dien-2-yl] (E)-3-phenylprop-2-enoate Show/Hide	C29H40O3	2
1	EC50 = 10500 nM Bioactivity Info	TI LI LO TS
2	IC50 = 94400 nM Bioactivity Info	TI LI LO TS
CP0385305 Compound Info	(1S,3R,5S,8E,12S,13R)-5,9,13-trimethyl-1-propan-2-yl-4,16-dioxatricyclo[11.2.1.03,5]hexadec-8-en-12-ol Show/Hide	C20H34O3	2
1	EC50 = 25400 nM Bioactivity Info	TI LI LO TS
2	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0079715 Compound Info	1-hydroxy-5-methyl-2-isopropylbenzene Show/Hide	C10H14O	1
1	EC50 = 29000 nM Bioactivity Info	TI LI LO TS
CP0385306 Compound Info	(1S,2E,6R,8S,11E)-3,8,12,16-tetramethyl-7,18-dioxatricyclo[13.3.0.06,8]octadeca-2,11,15-triene Show/Hide	C20H30O2	2
1	EC50 = 29200 nM Bioactivity Info	TI LI LO TS
2	IC50 = 57500 nM Bioactivity Info	TI LI LO TS
CP0432888 Compound Info	(1S,2E,6R,8S,11E)-3,8,12,16-tetramethyl-7,18-dioxatricyclo[13.3.0.06,8]octadeca-2,11,15-trien-17-one Show/Hide	C20H28O3	2
1	EC50 = 30100 nM Bioactivity Info	TI LI LO TS
2	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0423849 Compound Info	(3Z,6R,11aS)-7,8,10-trimethoxy-9-methyl-6-phenyl-3-[(2,4,5-trimethoxy-3-methylphenyl)methylidene]-11,11a-dihydro-6H-pyrazino[1,2-b]isoquinoline-1,4-dione Show/Hide	C33H36N2O8	1
1	IC50 = 34300 nM Bioactivity Info	TI LI LO TS
CP0420447 Compound Info	bis[(1S)-1-(4-fluorophenyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]methanone Show/Hide	C35H34F2N2O5	1
1	IC50 = 72900 nM Bioactivity Info	TI LI LO TS
CP0420446 Compound Info	bis[(1S)-1-(4-chlorophenyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]methanone Show/Hide	C35H34Cl2N2O5	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0420471 Compound Info	bis[(1S)-6,7-dimethoxy-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl]methanone Show/Hide	C35H36N2O5	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS

Similar Protein(s) and Bioactivity Statistics

90% Identity

Protein ID	Protein Name	Protein Organism
PT00646	Transient receptor potential cation channel, subfamily V, member 3	Rattus norvegicus, Rat	Protein Info
PT06923	Transient receptor potential cation channel subfamily V member 3	Mus musculus, Mouse	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han