General Information of the Protein
Protein ID
PT00632
Protein Name
Ecdysone receptor
Secondarily
Protein Name
20-hydroxy-ecdysone receptor
EcRH
Ecdysteroid receptor
Nuclear receptor subfamily 1 group H member 1
Sequence
MSIESRLDSLVRGKSEVKAFAGGCPSALLDTGACDTLADMRRRWYNNGGFQTLRMLEESSSEVTSSSALGLPPAMVMSPESLASPEYGGLELWGYEDGLTTYSMAQSLGSCTMEQQQQPQQQQQPQQTQPLPSMPLPMPPTTPKSENESMSSGREELSPASSVNGCSTDGEARRQKKGPAPRQQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKNAVYICKFGHACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQCAMKRKEKKAQREKDKLPVSTTTVDDHMPPIMQCDPPPPEAARIHEVVPRFLTEKILEQNRLKNVPPLTTNQKSLIARLVWYQEGYEQPSEEDLKRVTQSDEDDEESDMPFRQITEMTILTVQLIVEFAKGLPGFAKISQSDQITLLKACSSEVMMLRVARRYDASTDSVLFANNQAYTRDNYRKAGMAYVIEDLLHFCRCMYAMSMDNVQYALLTAIVIFSDRPGLEQPLLVEEIQRYYLNTLRMYVLNQHSASPRCPVVFGKILGVLTELRTLGMQNSNMCISLKLKNRKLPPFLEEIWDVADVSTTATPAAPVTETAAL
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Organism
Spodoptera littoralis, Egyptian cotton leafworm
Protein Classification
Transcription factor
>
Nuclear receptor
Uniprot ID
E3UJZ5
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000090 , Schneider 2
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0010630
 Compound Info 
CHEBI:38452
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C22H28N2O2
  1
1
EC50 = 2.188 nM
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CP0452440
 Compound Info 
CHEBI:38450
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C24H30N2O3
  1
1
EC50 = 2.63 nM
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CP0001251
 Compound Info 
N-[1-(3,5-dimethylbenzoyl)cyclohexyl]-5-methyl-3,4-dihydro-2H-chromene-6-carboxamide
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C26H31NO3
  1
1
EC50 = 3.388 nM
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CP0415943
 Compound Info 
N'-tert-butyl-N'-(2-chlorobenzoyl)-5-methyl-3,4-dihydro-2H-chromene-6-carbohydrazide
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C22H25ClN2O3
  1
1
EC50 = 5.37 nM
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CP0001249
 Compound Info 
3-methoxy-2-methylbenzoic acid 2-(3,5-dimethylbenzoyl)-2-(1,1-dimethylethyl)hydrazide
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C22H28N2O3
  1
1
EC50 = 6.026 nM
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CP0417742
 Compound Info 
N-tert-butyl-N'-(4-tert-butylbenzoyl)-3,5-dimethylbenzohydrazide
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C24H32N2O2
  1
1
EC50 = 7.079 nM
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CP0380205
 Compound Info 
N'-tert-butyl-N'-(3,5-dimethylbenzoyl)-2,3-dimethylbenzohydrazide
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C22H28N2O2
  1
1
EC50 = 16.22 nM
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CP0004427
 Compound Info 
N-tert-butyl-2-chloro-N'-(4-propan-2-ylbenzoyl)benzohydrazide
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C21H25ClN2O2
  1
1
EC50 = 17.38 nM
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CP0440780
 Compound Info 
N'-tert-butyl-N'-(2-chloro-3,5-dimethylbenzoyl)-5-methyl-3,4-dihydro-2H-chromene-6-carbohydrazide
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C24H29ClN2O3
  1
1
EC50 = 67.61 nM
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CP0001677
 Compound Info 
N-tert-butyl-2-chloro-N'-(4-propylbenzoyl)benzohydrazide
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C21H25ClN2O2
  1
1
EC50 = 74.13 nM
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CP0010026
 Compound Info 
N'-benzoyl-N'-tert-butyl-4-ethylbenzohydrazide
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C20H24N2O2
  1
1
EC50 = 109.65 nM
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CP0007594
 Compound Info 
N-[1-(3,5-dimethylbenzoyl)cyclohexyl]-4-ethylbenzamide
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C24H29NO2
  1
1
EC50 = 120.23 nM
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CP0012429
 Compound Info 
N-[3-(3,5-dimethylbenzoyl)pentan-3-yl]-5-methyl-3,4-dihydro-2H-chromene-6-carboxamide
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C25H31NO3
  1
1
EC50 = 165.96 nM
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CP0003340
 Compound Info 
N'-tert-butyl-N'-(2-chlorobenzoyl)-2-fluorobenzohydrazide
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C18H18ClFN2O2
  1
1
EC50 = 288.4 nM
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CP0452436
 Compound Info 
N-tert-butyl-2-chloro-N'-(4-pentylbenzoyl)benzohydrazide
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C23H29ClN2O2
  1
1
EC50 = 323.59 nM
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CP0008167
 Compound Info 
N-tert-butyl-2-chloro-N'-(4-methoxybenzoyl)benzohydrazide
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C19H21ClN2O3
  1
1
EC50 = 338.84 nM
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CP0440788
 Compound Info 
N-tert-butyl-2-chloro-N'-(4-ethylbenzoyl)-3,5-dimethylbenzohydrazide
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C22H27ClN2O2
  1
1
EC50 = 338.84 nM
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CP0010921
 Compound Info 
N'-(4-bromobenzoyl)-N-tert-butyl-2-chlorobenzohydrazide
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C18H18BrClN2O2
  1
1
EC50 = 436.52 nM
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CP0011651
 Compound Info 
N'-tert-butyl-N'-(2-chlorobenzoyl)-2-methylbenzohydrazide
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C19H21ClN2O2
  1
1
EC50 = 436.52 nM
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CP0006680
 Compound Info 
CHEBI:38451
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C18H19ClN2O2
  1
1
EC50 = 457.09 nM
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CP0415928
 Compound Info 
N-tert-butyl-N'-(3-fluorobenzoyl)-2-methylbenzohydrazide
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C19H21FN2O2
  1
1
EC50 = 457.09 nM
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CP0005747
 Compound Info 
N'-benzoyl-N-tert-butyl-3,5-dimethylbenzohydrazide
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C20H24N2O2
  1
1
EC50 = 501.19 nM
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CP0008676
 Compound Info 
N'-benzoyl-N-tert-butyl-2-(trifluoromethyl)benzohydrazide
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C19H19F3N2O2
  1
1
EC50 = 794.33 nM
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CP0415945
 Compound Info 
N-tert-butyl-2-chloro-N'-(4-chlorobenzoyl)-3,5-dimethylbenzohydrazide
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C20H22Cl2N2O2
  1
1
EC50 = 1071.52 nM
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CP0417744
 Compound Info 
N-tert-butyl-N'-(4-butylbenzoyl)-2-chloro-3,5-dimethylbenzohydrazide
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C24H31ClN2O2
  1
1
EC50 = 1122.02 nM
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CP0001518
 Compound Info 
CHEBI:38457
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C18H20N2O2
  1
1
EC50 = 1288.25 nM
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CP0415944
 Compound Info 
N-tert-butyl-2-chloro-3,5-dimethyl-N'-(4-methylbenzoyl)benzohydrazide
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C21H25ClN2O2
  1
1
EC50 = 1348.96 nM
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CP0005221
 Compound Info 
N-tert-butyl-2-chloro-N'-(3-chlorobenzoyl)benzohydrazide
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C18H18Cl2N2O2
  1
1
EC50 = 1698.24 nM
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CP0007773
 Compound Info 
N'-benzoyl-N-tert-butyl-2-chloro-3,5-dimethylbenzohydrazide
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C20H23ClN2O2
  1
1
EC50 = 1737.8 nM
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CP0391250
 Compound Info 
N-tert-butyl-2-chloro-N'-(4-methoxybenzoyl)-3,5-dimethylbenzohydrazide
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C21H25ClN2O3
  1
1
EC50 = 2041.74 nM
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CP0442306
 Compound Info 
N-tert-butyl-2-chloro-3,5-dimethyl-N'-(4-pentylbenzoyl)benzohydrazide
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C25H33ClN2O2
  1
1
EC50 = 3548.13 nM
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CP0005748
 Compound Info 
N-[3-(3,5-dimethylbenzoyl)pentan-3-yl]-4-ethylbenzamide
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C23H29NO2
  1
1
EC50 = 4265.8 nM
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CP0452439
 Compound Info 
N'-benzoyl-N-tert-butyl-2,3,4-trichlorobenzohydrazide
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C18H17Cl3N2O2
  1
1
EC50 = 5248.07 nM
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CP0005378
 Compound Info 
N-tert-butyl-2-ethoxy-N'-(4-ethylbenzoyl)benzohydrazide
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C22H28N2O3
  1
1
EC50 = 6918.31 nM
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CP0415942
 Compound Info 
N-tert-butyl-N'-(4-butylbenzoyl)-2-ethoxybenzohydrazide
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C24H32N2O3
  1
1
EC50 = 7762.47 nM
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CP0460465
 Compound Info 
N-tert-butyl-N'-(4-chlorobenzoyl)-2-ethoxybenzohydrazide
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C20H23ClN2O3
  1
1
EC50 = 9549.93 nM
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CP0417741
 Compound Info 
N-tert-butyl-2-ethoxy-N'-(4-methoxybenzoyl)benzohydrazide
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C21H26N2O4
  1
1
EC50 = 21877.62 nM
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CP0007383
 Compound Info 
N-[1-(3,5-dimethylphenyl)-3,3-dimethyl-1-oxobutan-2-yl]-4-ethylbenzamide
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C23H29NO2
  2
1
EC50 = 46773.51 nM
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2
IC50 = 23988.33 nM
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CP0004753
 Compound Info 
(4-chlorophenyl)-[6-fluoro-4-(4-fluoroanilino)-2-methyl-3,4-dihydro-2H-quinolin-1-yl]methanone
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C23H19ClF2N2O
  1
1
EC50 = 60000 nM
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CP0007786
 Compound Info 
N-[1-(3,5-dimethylbenzoyl)cyclohexyl]-2,2,2-trifluoroacetamide
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C17H20F3NO2
  2
1
EC50 < 100000 nM
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2
IC50 = 16218.1 nM
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CP0011590
 Compound Info 
4-chloro-N-[1-(4-chlorobenzoyl)-2,6-dimethyl-3,4-dihydro-2H-quinolin-4-yl]-N-(4-methylphenyl)benzamide
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C32H28Cl2N2O2
  1
1
IC50 = 12882.5 nM
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CP0008229
 Compound Info 
(4-chlorophenyl)-[4-(4-methylanilino)piperidin-1-yl]methanone
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C19H21ClN2O
  1
1
IC50 = 15135.61 nM
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CP0011652
 Compound Info 
(4-tert-butylphenyl)-[2,6-dimethyl-4-(4-methylanilino)-3,4-dihydro-2H-quinolin-1-yl]methanone
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C29H34N2O
  1
1
IC50 > 25118.86 nM
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CP0012428
 Compound Info 
(4-chlorophenyl)-(2-methyl-3,4-dihydro-2H-quinolin-1-yl)methanone
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C17H16ClNO
  1
1
IC50 = 54954.09 nM
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CP0003997
 Compound Info 
[2,6-dimethyl-4-(4-methylanilino)-3,4-dihydro-2H-quinolin-1-yl]-(4-methylphenyl)methanone
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C26H28N2O
  1
1
IC50 = 74131.02 nM
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CP0007800
 Compound Info 
(4-chlorophenyl)-[2,6-dimethyl-4-(4-methylanilino)-3,4-dihydro-2H-quinolin-1-yl]methanone
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C25H25ClN2O
  1
1
IC50 = 79432.82 nM
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Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT06098 Ecdysone receptor Bombyx mori, Silk moth
 Protein Info