General Information of the Protein
Protein ID
PT00623
Protein Name
Amino acid transporter
Gene Name
SLC1A5
Sequence
MAVDPPKADPKGVVAVDPTANCGSGLKSREDQGAKAGGCCSSRDQVCRCLRANLLVLLTVAAAVAGVVLGLGVSAAGGAEALGHARFTAFAFPGELLLRLLEMIILPLVVCSLIGGAASLDPSALGRLGAWALLFFLVTTLLSSALGVALALALKPGAAFAAINSSVVDSSVHRAPTKEVLDSFLELLRNMFPSNLVSASAAFRIPCGACPQRSNATMDQPHCEMKMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNDATMVLVSWIMWYAPIGILFLVAGKIVEMKDIRQLFIGLGKYIVCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEEKNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLNGMSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAISLPVKDISLILAVDWLVDRSCTVLNVEGDAFGAGLLQSYVDRTKMPSSEPELIQVKNDVSLKPLPLATEEGNPLLKQCREPSGDSSATCEKESVM
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Organism
Rattus norvegicus, Rat
Protein Classification
Transporter
Uniprot ID
Q9Z1J7
Ensembl ID
ENSG00000105281
Subcellular Location
Cell membrane
Melanosome
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000049 , C6
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0493739
 Compound Info 
(2S)-2-amino-4-[bis[[2-(3-methoxyphenoxy)phenyl]methyl]amino]butanoic acid
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C32H34N2O6
  1
1
IC50 = 1300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0392528
 Compound Info 
(2S)-2-amino-4-[bis[[2-(2-fluorophenoxy)phenyl]methyl]amino]butanoic acid
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C30H28F2N2O4
  1
1
IC50 = 1800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0407978
 Compound Info 
(2S)-2-amino-4-[bis[[2-[(2-fluorophenyl)methoxy]phenyl]methyl]amino]butanoic acid
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C32H32F2N2O4
  1
1
IC50 = 3300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0539870
 Compound Info 
(2S)-2-amino-4-[bis[[2-[(3-methoxyphenyl)methoxy]phenyl]methyl]amino]butanoic acid
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C34H38N2O6
  1
1
IC50 = 5100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0474641
 Compound Info 
(2S)-2-amino-4-[bis[[2-(pyridin-2-ylmethoxy)phenyl]methyl]amino]butanoic acid
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C30H32N4O4
  1
1
IC50 = 8400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0474639
 Compound Info 
(2S)-2-amino-4-[bis[[2-(4-methoxyphenoxy)phenyl]methyl]amino]butanoic acid
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C32H34N2O6
  1
1
IC50 = 8700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0474637
 Compound Info 
(2S)-2-amino-4-[bis[[2-[(3-methylphenyl)methoxy]phenyl]methyl]amino]butanoic acid
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C34H38N2O4
  1
1
IC50 = 9000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0463006
 Compound Info 
(2S)-2-amino-4-[bis[[2-(4-fluorophenoxy)phenyl]methyl]amino]butanoic acid
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C30H28F2N2O4
  1
1
IC50 = 10500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0385704
 Compound Info 
(2S)-2-amino-4-[bis[[2-[(4-fluorophenyl)methoxy]phenyl]methyl]amino]butanoic acid
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C32H32F2N2O4
  1
1
IC50 = 11200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0407979
 Compound Info 
(2S)-2-amino-4-[bis[[2-[(3-chlorophenyl)methoxy]phenyl]methyl]amino]butanoic acid
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C32H32Cl2N2O4
  1
1
IC50 = 12700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0407977
 Compound Info 
(2S)-2-amino-4-[bis[[2-(pyridin-3-ylmethoxy)phenyl]methyl]amino]butanoic acid
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C30H32N4O4
  1
1
IC50 = 17300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0407980
 Compound Info 
(2S)-2-amino-4-[bis[[2-[(2-chlorophenyl)methoxy]phenyl]methyl]amino]butanoic acid
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C32H32Cl2N2O4
  1
1
IC50 = 18400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0463005
 Compound Info 
(2S)-2-amino-4-[bis[[2-[(4-chlorophenyl)methoxy]phenyl]methyl]amino]butanoic acid
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C32H32Cl2N2O4
  1
1
IC50 = 20100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0474636
 Compound Info 
(2S)-2-amino-4-[bis[[2-[[3-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]amino]butanoic acid
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C34H32F6N2O4
  1
1
IC50 = 22500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0392529
 Compound Info 
(2S)-2-amino-4-[bis[[2-(4-chlorophenoxy)phenyl]methyl]amino]butanoic acid
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C30H28Cl2N2O4
  1
1
IC50 = 24300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0404439
 Compound Info 
(2S)-2-amino-4-[bis[[2-(3-fluorophenoxy)phenyl]methyl]amino]butanoic acid
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C30H28F2N2O4
  1
1
IC50 = 36300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0456517
 Compound Info 
(2S)-2-amino-4-[bis[[2-[(2-methylphenyl)methoxy]phenyl]methyl]amino]butanoic acid
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C34H38N2O4
  1
1
IC50 = 41700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0474638
 Compound Info 
(2S)-2-amino-4-[bis[(2-pyridin-2-yloxyphenyl)methyl]amino]butanoic acid
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C28H28N4O4
  1
1
IC50 = 68200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0109474
 Compound Info 
(2S)-2-azaniumyl-5-(4-nitroanilino)-5-oxopentanoate
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C11H13N3O5
  1
1
IC50 = 70200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0392532
 Compound Info 
(2S)-2-amino-4-[bis[[2-[(4-methylphenyl)methoxy]phenyl]methyl]amino]butanoic acid
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C34H38N2O4
  1
1
IC50 = 86400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000006 , HEK293
 Cell Line Info