General Information of the Protein
Protein ID
PT00487
Protein Name
NS5
Sequence
EFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWMGRENSGGGVEGLGLQRLGYVLEEMSRIPGGRMYADDTAGWDTRISRFDLENEALITNQMEKGHRALALAIIKYTYQNKVVKVLRPAEKGKTVMDIISRQDQRGSGQVVTYALNTFTNLVVQLIRNMEAEEVLEMQDLWLLRRSEKVTNWLQSNGWDRLKRMAVSGDDCVVKPIDDRFAHALRFLNDMGKVRKDTQEWKPSTGWDNWEEVPFCSHHFNKLHLKDGRSIVVPCRHQDELIGRARVSPGAGWSIRETACLAKSYAQMWQLLYFHRRDLRLMANAICSSVPVDWVPTGRTTWSIHGKGE
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Organism
Zika virus, ZIKV
Protein Classification
Enzyme
>
Transferase
Uniprot ID
A0A143MHK7
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000057 , Vero
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0539328
 Compound Info 
(1R,2S,3S,5R)-3-(6-aminopurin-9-yl)-4,4-difluoro-5-(hydroxymethyl)cyclopentane-1,2-diol
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C11H13F2N5O3
  1
1
EC50 = 260 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0082264
 Compound Info 
(1R,2S,3R,5R)-3-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol
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C11H15N5O3
  1
1
EC50 = 640 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0532006
 Compound Info 
propan-2-yl (2S)-2-[[[(1R,3S,4S,5R)-3-(6-aminopurin-9-yl)-2,2-difluoro-4,5-dihydroxycyclopentyl]methoxy-phenoxyphosphoryl]amino]propanoate
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C23H29F2N6O7P
  1
1
EC50 = 1750 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0538195
 Compound Info 
(1R,2S,3S,4S,5R)-3-(6-aminopurin-9-yl)-4-fluoro-5-(hydroxymethyl)cyclopentane-1,2-diol
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C11H14FN5O3
  1
1
EC50 = 2540 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0431688
 Compound Info 
propan-2-yl (2S)-2-[[[(1R,3S,4S,5R)-3-(2,4-dioxopyrimidin-1-yl)-2,2-difluoro-4,5-dihydroxycyclopentyl]methoxy-phenoxyphosphoryl]amino]propanoate
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C22H28F2N3O9P
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0470743
 Compound Info 
(1S,2R,3R,5S)-4,4-difluoro-3-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]cyclopentane-1,2-diol
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C12H15F2N5O3
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0492063
 Compound Info 
(1S,2R,3R,4R,5S)-4-fluoro-3-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]cyclopentane-1,2-diol
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C12H16FN5O3
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0538196
 Compound Info 
1-[(1S,3R,4R,5S)-2,2-difluoro-4,5-dihydroxy-3-(hydroxymethyl)cyclopentyl]pyrimidine-2,4-dione
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C10H12F2N2O5
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0539314
 Compound Info 
1-[(1S,2S,3R,4R,5S)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)cyclopentyl]pyrimidine-2,4-dione
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C10H13FN2O5
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0539329
 Compound Info 
propan-2-yl (2S)-2-[[[(1R,2R,3S,4S,5R)-3-(2,4-dioxopyrimidin-1-yl)-2-fluoro-4,5-dihydroxycyclopentyl]methoxy-phenoxyphosphoryl]amino]propanoate
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C22H29FN3O9P
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0551669
 Compound Info 
4-amino-1-[(1S,2R,3R,4R,5S)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)cyclopentyl]pyrimidin-2-one
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C10H14FN3O4
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0553778
 Compound Info 
1-[(1S,2R,3R,4R,5S)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)cyclopentyl]pyrimidine-2,4-dione
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C10H13FN2O5
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0572694
 Compound Info 
4-amino-1-[(1S,3R,4R,5S)-2,2-difluoro-4,5-dihydroxy-3-(hydroxymethyl)cyclopentyl]pyrimidin-2-one
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C10H13F2N3O4
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0031380
 Compound Info 
CHEBI:85083
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C22H29FN3O9P
  1
1 EC50 = 120 nM