General Information of the Protein
Protein ID
PT00026
Protein Name
Genome polyprotein
Gene Name
NS3
Sequence
APITAYAQQTRGLLGCIITGLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAGTRTIASSKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDGRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVEGLETTMRSPVFSDNSSPPAVPQSYQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGIDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGSAYDIIICDECHSTDATSILGIGTVLDQAETAGARLTVLATATPPGSVTVPHPNIEEVALSTTGEIPFYGKAIPLEAIKGGRHLIFCHSKKKCDELAAKLVALGVNAVAYYRGLDVSVIPASGDVVVVATDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEITLTHPITKYIMTCMSADLEVVT
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Organism
Hepacivirus hominis
Protein Classification
Unclassified protein
Uniprot ID
A3EZJ3
Subcellular Location
Endoplasmic reticulum membrane
Host endoplasmic reticulum membrane
Virion
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000148 , Huh-7
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0404089
 Compound Info 
(2R,4S,7S)-7-tert-butyl-N-[(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-ethenylcyclopropyl]-2,18-dimethoxy-13,13-dimethyl-6,9-dioxo-10-oxa-5,8-diazatetracyclo[15.5.3.12,5.020,24]hexacosa-1(23),17,19,21,24-pentaene-4-carboxamide
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C41H56N4O9S
  2
1
EC50 = 0.2 nM
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2
EC50 = 0.3 nM
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CP0389077
 Compound Info 
(2R,4S,7S)-7-tert-butyl-N-[(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-ethenylcyclopropyl]-2,18-dimethoxy-6,9-dioxo-10-oxa-5,8-diazatetracyclo[15.5.3.12,5.020,24]hexacosa-1(23),17,19,21,24-pentaene-4-carboxamide
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C39H52N4O9S
  2
1
EC50 = 0.3 nM
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2
EC50 = 0.5 nM
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CP0559951
 Compound Info 
(2R,4S,7S)-7-tert-butyl-N-[(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-ethenylcyclopropyl]-2,17-dimethoxy-6,9-dioxo-10-oxa-5,8-diazatetracyclo[14.5.3.12,5.019,23]pentacosa-1(22),16,18,20,23-pentaene-4-carboxamide
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C38H50N4O9S
  2
1
EC50 = 0.6 nM
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2
EC50 = 2 nM
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CP0427723
 Compound Info 
(2R,4S,7S)-7-tert-butyl-N-[(1R,2S)-2-cyclopropyl-1-(cyclopropylsulfonylcarbamoyl)cyclopropyl]-2,18-dimethoxy-6,9-dioxo-10-oxa-5,8-diazatetracyclo[15.5.3.12,5.020,24]hexacosa-1(23),17,19,21,24-pentaene-4-carboxamide
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C40H54N4O9S
  2
1
EC50 = 1 nM
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2
EC50 = 1.8 nM
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CP0153399
 Compound Info 
[(2R)-1,1,1-trifluoropropan-2-yl] N-[(1S)-2-[(2S,4R)-4-(7-chloro-4-methoxyisoquinolin-1-yl)oxy-2-[[(1R,2S)-2-cyclopropyl-1-(cyclopropylsulfonylcarbamoyl)cyclopropyl]carbamoyl]pyrrolidin-1-yl]-1-cyclohexyl-2-oxoethyl]carbamate
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C37H45ClF3N5O9S
  2
1
EC50 = 1 nM
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2
EC50 = 4.5 nM
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CP0427811
 Compound Info 
Asunaprevir
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C35H46ClN5O9S
  2
1
EC50 = 1.2 nM
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2
EC50 = 4 nM
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CP0404088
 Compound Info 
(2R,4S,7S)-7-tert-butyl-N-[(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-ethenylcyclopropyl]-2,18-dimethoxy-12,12-dimethyl-6,9-dioxo-10-oxa-5,8-diazatetracyclo[15.5.3.12,5.020,24]hexacosa-1(23),17,19,21,24-pentaene-4-carboxamide
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C41H56N4O9S
  2
1
EC50 = 1.8 nM
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2
EC50 = 2.2 nM
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CP0427810
 Compound Info 
(2R,4S,7S)-7-tert-butyl-N-[(1R,2S)-2-cyclopropyl-1-(cyclopropylsulfonylcarbamoyl)cyclopropyl]-2,18-dimethoxy-13,13-dimethyl-6,9-dioxo-10-oxa-5,8-diazatetracyclo[15.5.3.12,5.020,24]hexacosa-1(23),17,19,21,24-pentaene-4-carboxamide
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C42H58N4O9S
  2
1
EC50 = 3 nM
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2
EC50 = 6 nM
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CP0484737
 Compound Info 
methyl (2R,4S,7S)-7-tert-butyl-4-[[(1R,2S)-2-cyclopropyl-1-(cyclopropylsulfonylcarbamoyl)cyclopropyl]carbamoyl]-2,19-dimethoxy-6,9-dioxo-10,17-dioxa-5,8,13-triazatetracyclo[16.5.3.12,5.021,25]heptacosa-1(24),18,20,22,25-pentaene-13-carboxylate
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C41H55N5O12S
  2
1
EC50 = 4 nM
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2
EC50 = 18 nM
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CP0427725
 Compound Info 
(2R,4S,7S)-7-tert-butyl-N-[(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-ethenylcyclopropyl]-2,16-dimethoxy-6,9-dioxo-10-oxa-5,8-diazatetracyclo[13.5.3.12,5.018,22]tetracosa-1(21),15,17,19,22-pentaene-4-carboxamide
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C37H48N4O9S
  2
1
EC50 = 5 nM
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2
EC50 = 16 nM
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CP0416847
 Compound Info 
(2R,4S,7S)-7-tert-butyl-13-cyclopropyl-N-[(1R,2S)-2-cyclopropyl-1-(cyclopropylsulfonylcarbamoyl)cyclopropyl]-2,19-dimethoxy-6,9-dioxo-10,17-dioxa-5,8,13-triazatetracyclo[16.5.3.12,5.021,25]heptacosa-1(24),18,20,22,25-pentaene-4-carboxamide
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C42H57N5O10S
  2
1
EC50 = 5 nM
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2
EC50 = 15 nM
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CP0567191
 Compound Info 
(2R,4S,7S)-7-tert-butyl-N-[(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-ethenylcyclopropyl]-2-methoxy-6,9-dioxo-10,16-dioxa-5,8-diazatetracyclo[15.5.3.12,5.020,24]hexacosa-1(23),17(25),18,20(24),21-pentaene-4-carboxamide
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C37H48N4O9S
  2
1
EC50 = 7 nM
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2
EC50 = 13 nM
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CP0548547
 Compound Info 
(2R,4S,7S)-7-tert-butyl-N-[(1R,2S)-2-cyclopropyl-1-(cyclopropylsulfonylcarbamoyl)cyclopropyl]-2,18-dimethoxy-12,12-dimethyl-6,9-dioxo-10-oxa-5,8-diazatetracyclo[15.5.3.12,5.020,24]hexacosa-1(23),17,19,21,24-pentaene-4-carboxamide
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C42H58N4O9S
  2
1
EC50 = 8 nM
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2
EC50 = 11 nM
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CP0416845
 Compound Info 
(2R,4S,7S)-7-tert-butyl-N-[(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-ethenylcyclopropyl]-2,20-dimethoxy-6,9-dioxo-10-oxa-5,8-diazatetracyclo[17.5.3.12,5.022,26]octacosa-1(25),19,21,23,26-pentaene-4-carboxamide
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C41H56N4O9S
  2
1
EC50 = 16 nM
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2
EC50 = 22 nM
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CP0416846
 Compound Info 
(2R,4S,7S)-7-tert-butyl-N-[(1R,2S)-2-cyclopropyl-1-(cyclopropylsulfonylcarbamoyl)cyclopropyl]-2-methoxy-6,9-dioxo-10,16-dioxa-5,8-diazatetracyclo[15.5.3.12,5.020,24]hexacosa-1(23),17(25),18,20(24),21-pentaene-4-carboxamide
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C38H50N4O9S
  2
1
EC50 = 27 nM
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2
EC50 = 35 nM
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CP0563690
 Compound Info 
tert-butyl N-[(2S)-1-[(2S,4R)-2-[[(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-ethenylcyclopropyl]carbamoyl]-4-methoxy-4-(6-methoxynaphthalen-2-yl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate
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C37H50N4O9S
  2
1
EC50 = 34 nM
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2
EC50 = 55 nM
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CP0404310
 Compound Info 
(2R,4S,7S)-7-tert-butyl-N-[(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-ethenylcyclopropyl]-2,19-dimethoxy-6,9-dioxo-10-oxa-5,8-diazatetracyclo[16.5.3.12,5.021,25]heptacosa-1(24),18,20,22,25-pentaene-4-carboxamide
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C40H54N4O9S
  2
1
EC50 = 35 nM
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2
EC50 = 96 nM
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CP0569246
 Compound Info 
tert-butyl N-[(2S)-1-[(2S,4R)-2-[[(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-ethenylcyclopropyl]carbamoyl]-4-(7-ethenyl-6-methoxynaphthalen-2-yl)-4-methoxypyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate
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C39H52N4O9S
  1
1
EC50 = 50 nM
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CP0908995
 Compound Info 
(13R,15S,12S)-12-(tert-butyl)-N-((1S,2R)-2-((cyclopropylsulfonyl)carbamoyl)-[1,1'-bi(cyclopropan)]-2-yl)-13,26-dimethoxy-6-methyl-10,13-dioxo-9-oxa-6,11-diaza-1(3,1)-pyrrolidina-2(2,7)-naphthalenacyclotridecaphane-15-carboxamide
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C40H55N5O10S
  2
1
EC50 = 52 nM
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2
EC50 = 69 nM
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CP0427803
 Compound Info 
(2R,4S,7S)-7-tert-butyl-N-[(1R,2S)-2-cyclopropyl-1-(cyclopropylsulfonylcarbamoyl)cyclopropyl]-2,19-dimethoxy-6,9-dioxo-13-propan-2-yl-10,17-dioxa-5,8,13-triazatetracyclo[16.5.3.12,5.021,25]heptacosa-1(24),18,20,22,25-pentaene-4-carboxamide
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C42H59N5O10S
  2
1
EC50 = 63 nM
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2
EC50 = 130 nM
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CP0536858
 Compound Info 
tert-butyl N-[(2S)-1-[(2S,4R)-2-[[(1R,2S)-2-cyclopropyl-1-(cyclopropylsulfonylcarbamoyl)cyclopropyl]carbamoyl]-4-methoxy-4-(6-methoxynaphthalen-2-yl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate
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C38H52N4O9S
  2
1
EC50 = 244 nM
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2
EC50 = 253 nM
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CP0404311
 Compound Info 
(1,1,1-trifluoro-2-methylpropan-2-yl) N-[(2S)-1-[(2S,4R)-2-[[(1R,2S)-2-cyclopropyl-1-(cyclopropylsulfonylcarbamoyl)cyclopropyl]carbamoyl]-4-methoxy-4-(6-methoxynaphthalen-2-yl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate
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C38H49F3N4O9S
  2
1
EC50 = 302 nM
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2
EC50 = 320 nM
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