General Information of the Protein
Protein ID
PT00010
Protein Name
Integrase
Gene Name
POL
Sequence
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
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Organism
Human immunodeficiency virus 1
Protein Classification
Enzyme
>
Hydrolase
Uniprot ID
Q7ZJM1
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000247 , MT-4
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0543740
 Compound Info 
2'-[(4-fluorophenyl)methyl]-4'-hydroxy-9'-methoxy-2',3'-dihydrospiro[cyclopropane-1,1'-pyrrolo[3,4-g]quinoline]-3'-one
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C21H17FN2O3
  1
1
IC50 = 7 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0530653
 Compound Info 
7-(4-fluorobenzyl)-6,9-dihydroxy-5-methoxy-6,7-dihydropyrrolo[3,4-g]quinolin-8-one
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C19H15FN2O4
  1
1
IC50 = 36 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0926806
 Compound Info 
7-(4-fluorobenzyl)-9-hydroxy-5-methoxy-6-(3-oxo-3-(piperazin-1-yl)propylthio)-6,7-dihydropyrrolo[3,4-g]quinolin-8-one trifluoroacetic acid salt
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C28H28F4N4O6S
  1
1
IC50 = 59 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0110259
 Compound Info 
7-[(4-fluorophenyl)methyl]-9-hydroxy-5-methoxy-6H,7H,8H-pyrrolo[3,4-g]quinolin-8-one
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C19H15FN2O3
  1
1
IC50 = 60 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0530654
 Compound Info 
7-(4-fluorobenzyl)-9-hydroxy-5,6-dimethoxy-6,7-dihydropyrrolo[3,4-g]quinolin-8-one
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C20H17FN2O4
  1
1
IC50 = 64 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0527701
 Compound Info 
7-(4-fluorobenzyl)-5,9-dihydroxy-7H-pyrrolo[3,4-g]quinoline-6,8-dione
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C18H11FN2O4
  1
1
IC50 = 80 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0456429
 Compound Info 
7-(4-fluorobenzyl)-9-hydroxy-5-methoxy-6-methyl-6,7-dihydropyrrolo[3,4-g]quinolin-8-one
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C20H17FN2O3
  1
1
IC50 = 88 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0543739
 Compound Info 
7-(4-fluorobenzyl)-9-hydroxy-5-methoxy-6-methylene-6,7-dihydropyrrolo[3,4-g]quinolin-8-one
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C20H15FN2O3
  1
1
IC50 = 150 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0530652
 Compound Info 
7-(4-fluorobenzyl)-9-hydroxy-5-methoxy-6,6-dimethyl-6,7-dihydropyrrolo[3,4-g]quinolin-8-one
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C21H19FN2O3
  1
1
IC50 = 210 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0319944
 Compound Info 
7-(4-fluorobenzyl)-9-hydroxy-8-oxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl dimethylsulfamate
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C20H18FN3O5S
  1
1
IC50 = 255 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0374891
 Compound Info 
3-(7-(4-fluorobenzyl)-9-hydroxy-5-methoxy-8-oxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-6-ylthio)propanoic acid
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C22H19FN2O5S
  1
1
IC50 = 295 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0515865
 Compound Info 
methyl 3-[[7-[(4-fluorophenyl)methyl]-9-hydroxy-5-methoxy-8-oxo-6H-pyrrolo[3,4-g]quinolin-6-yl]sulfanyl]propanoate
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C23H21FN2O5S
  1
1
IC50 = 310 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0525160
 Compound Info 
2'-[(4-fluorophenyl)methyl]-4'-hydroxy-3'-oxo-2',3'-dihydrospiro[cyclopropane-1,1'-pyrrolo[3,4-g]quinoline]-9'-yl N,N-dimethylsulfamate
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C22H20FN3O5S
  1
1
IC50 = 357 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0449421
 Compound Info 
7-(4-fluorobenzyl)-9-hydroxy-6-methylene-8-oxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl dimethylsulfamate
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C21H18FN3O5S
  1
1
IC50 = 420 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0515778
 Compound Info 
7-(4-fluorobenzyl)-9-hydroxy-6-methyl-8-oxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl dimethylsulfamate
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C21H20FN3O5S
  1
1
IC50 = 815 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0110259
 Compound Info 
7-[(4-fluorophenyl)methyl]-9-hydroxy-5-methoxy-6H,7H,8H-pyrrolo[3,4-g]quinolin-8-one
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C19H15FN2O3
  1
1 IC50 = 50 nM
CP0319944
 Compound Info 
7-(4-fluorobenzyl)-9-hydroxy-8-oxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl dimethylsulfamate
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C20H18FN3O5S
  2
1 IC50 = 250 nM
2 IC50 = 255 nM
CP0297513
 Compound Info 
(E)-2-(2-(furan-2-yl)vinyl)-8-hydroxyquinoline-7-carboxylic acid
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C16H11NO4
  1
1 IC50 = 1905.46 nM