General Information of the Compound
Compound ID
CP0449421
Compound Name
7-(4-fluorobenzyl)-9-hydroxy-6-methylene-8-oxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl dimethylsulfamate
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Formula
C21H18FN3O5S
Molecular Weight
443.456
Canonical SMILES
CN(C)S(=O)(=O)Oc1c2C(=C)N(Cc3ccc(F)cc3)C(=O)c2c(O)c2ncccc12
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InChI
InChI=1S/C21H18FN3O5S/c1-12-16-17(21(27)25(12)11-13-6-8-14(22)9-7-13)19(26)18-15(5-4-10-23-18)20(16)30-31(28,29)24(2)3/h4-10,26H,1,11H2,2-3H3
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InChIKey
VTUOOQGXKLBRMW-UHFFFAOYSA-N
Physicochemical Property
logP
2.8914
Rotatable Bonds
5
Heavy Atom Count
31
Polar Areas
100.04
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
SID: 15428763
ChEMBL ID
CHEMBL377621
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00010, Integrase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000247 MT-4 Homo sapiens (Human)  1
1
IC50 = 420 nM
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